ROCCK (Reducing Obesity) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn about how weight loss can effect knee cartilage.
If you are interested in participating in our study, please email us at:

What is the Condition Being Studied?

Obesity and Weight-loss

Who Can Participate in the Study?

Adults age 18-45 who:
- Have healthy knees
- Obese with BMI between 30-40

Age Group

What is Involved?

If you choose to join this study, you will:
- Have 3 MRIs over 6 months
- Have blood and urine collected
- Meet weekly for 1 hour weight classes
- Be randomized (like flipping a coin) into one of two groups:
---Group 1: Weight loss group for 6 months
---Group 2: Weight maintenance for 6 months, and weight loss activities offered after the study

Study Details

Full Title
Reducing Obesity and Cartilage Compression in Knees
Principal Investigator
Louis Defrate
Protocol Number
IRB: PRO00102409
Phase N/A
Enrollment Status
Open for Enrollment
Contact the Duke Recruitment Innovation Center