PHAETHON (Brain Cancer) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to understand whether a MRS scan can be used to find 2-HG (2-hydroxyglutarate) in the brain.

2-HG is a chemical sometimes found in the brain when specific types of a protein called isocitrate dehydrogenase (IDH) are present. In the future, we hope to use 2-HG as a way to find out what kind of brain tumor someone has without surgery.

What is the Condition Being Studied?

People with brain masses who are scheduled for a craniotomy (brain surgery).

Who Can Participate in the Study?

Adults,18+ who:
-Are scheduled for craniotomy (brain surgery)
-Have a brain mass 1 centimeter or larger within 2 months of scheduled surgery
-Are able to undergo MRS scan
-Have not had treatment of their brain mass with surgery, radiation therapy, and/or chemotherapy

Age Group
Adults

What is Involved?

If you choose to join this study, you will:
-Have an Magnetic Resonance Spectroscopy (MRS) scan of your brain before your surgery
-Possibly be asked to do another MRS Scan on the same day or the day after your first MRS scan
-Allow the study team to read your report after your brain surgery

For more information about who can be in this study, please contact the study team.

Study Details

Full Title
A Pilot Study of 2HG Imaging in Subjects with Brain Lesions who are Undergoing a Craniotomy
Principal Investigator
Protocol Number
IRB: PRO00102098
Phase
Phase N/A
Enrollment Status
Open for Enrollment
Participate
Contact the Duke Recruitment Innovation Center
MyResearchPartners@duke.edu
or
919-681-5698