BMX-MBM-001 (Brain Metastases) - Clinical Trial
What is the Purpose of this Study?
We are doing this study is to find out what effects (good or bad) the study drug, BMX-001, may have on memory and thinking when given with whole brain radiation therapy for cancer that has spread to the brain.
Who Can Participate in the Study?
- Have primarily been diagnosed with non-small cell lung cancer, breast cancer, melanoma or renal cancer and the cancer has spread to the brain
- Have greater than 10 brain tumors with radiation treatment plan to include whole brain radiation
- Negative pregnancy test for women who could become pregnant
What is Involved?
If you choose to join this study, you will:
- Be randomly assigned (like the flip of a coin) to one of two groups:
-- Group 1 will get the study drug, BMX-001 in an shot under the skin and whole brain radiation therapy. You will get the first shot a couple of days before radiation therapy starts, and twice a week during radiation therapy. The last shot is given about 2 days after radiation therapy is finished.
-- Group 2 will only get whole brain radiation therapy
-- Provide information on your quality of life, side effects of treatment, survival and neurocognitive effects before and after whole brain radiation therapy is given