AMG 510: Phase 1 for Colorectal Cancer and Non-Small cell Lung Cancer - Clinical Trial
What is the Purpose of this Study?
We are doing this study to find out if a new study drug, AMG 510, for colorectal cancer patients with a specific genetic mutation is safe and if your body can handle the potential side effects.
We will also try to find what dose of the study drug is safe for patients to take.
Colorectal Cancer and Non-Small cell Lung Cancer
Who Can Participate in the Study?
-Have colorectal or non-small cell lung cancer with a documented KRAS p.G12C mutation
- Are considered non-small cell lung cancer patients (you must have had prior treatment with platinum-based combination therapy and/or targeted therapies)
-Are considered colorectal cancer participants (you must have had prior treatment with 2 prior systemic therapies)
What is Involved?
If you choose to join this study, you will:
- Take the study drug, AMG 510, by mouth, once a day
--The study drug regimen will be given in 3 week cycles
--During each cycle, you will need to visit the clinic 5 times during the first cycle, 2 times during the second cycle, and once per cycle for all the remaining cycles
-The cycles of the study drug regimen that you will receive will depend on the side effects that you get
-During your clinic visits blood samples and other procedures will be performed