I-ATTAC (Brain Tumor) - Clinical Trial

We are doing this study to confirm that our vaccine can stimulate your immune system and is safe to receive.

Grade IV malignant glioma (brain tumor) that is newly diagnosed

Adults age 18 and older who:
-Have been newly diagnosed with Grade IV malignant glioma
-Have antibodies against cytomegalovirus in your blood
-Do not have severe reactions to imaging contrast dyes (used during an MRI)
-Do not have anything in your body that would prevent you from having an MRI (such as metal in your body)

For more information about who can be in this study, please contact the study team.

If you choose to join this study, you will:
-Have a procedure where your blood is taken out of a vein in one arm, goes through a machine that takes out white blood cells, and then returns the remaining blood into a vein in the other arm.
-We then take your white blood cells and create vaccines in a lab at Duke.
-Have standard radiation treatment and chemotherapy over 6 weeks
-Have one cycle of high-dose chemotherapy
-Have a tetanus shot
-Receive 3 vaccines (one every 2 weeks) followed by up to 7 more vaccines about every month
-Complete regular clinic visits to receive vaccines and have physical examinations, bloodwork, and regular MRIs.
-Be a part of this study for up to 2 years