BRAVOS for dcSSc - Clinical Trial

We are doing this study to find out if the study drug, brentuximab vedotin, is safe and will reduce symptoms in people who have dcSSc.

Diffuse Cutaneous Systemic Sclerosis (dcSSc)

Adults age 18-70 who have been diagnosed with dcSSC for 5 years or less

If you choose to join this study, you will:
- Be randomized (like flipping a coin) to get the study drug, brentuximab vedotin, or a placebo (an inactive pill)
- Have physical exams, EKGs, and echocardiograms (an ultrasound test of your heart)
- Have a tuberculosis skin test, breathing (pulmonary function) test, and routine blood tests
- Have two skin biopsies