UM1 10021 Durvalumab & Tremelimumab +/- Radiation in mCRC & NSCLC - Clinical Trial
What is the Purpose of this Study?
We are doing this study to test any good and bad effects of the experimental study drugs, MEDI4736 (durvalumab) and tremelimumab given alone or in combination with either low or higher doses of radiation.
Advanced non-small cell lung cancer
Who Can Participate in the Study?
Adults with advanced non-small cell lung cancer that has progressed after receiving prior treatment(s)
What is Involved?
If you join this study, you will receive one of the three treatment options. The study group you will belong to will be decided by chance (like tossing a coin) because no one knows if one study group is better than the other
Group 1 will receive MEDI4736 (durvalumab) & tremelimumab only
Group 2 will receive MEDI4736 (durvalumab) & tremelimumab and 3 radiation treatments delivered on 3 different days. (each dose of radiation will be given to a higher dose than in group 3)
Group 3 will receive MEDI4736 (durvalumab) & tremelimumab and 4 radiation treatments delivered twice a day for 2 days during each of the first 4 cycles of treatment (each dose of radiation will be given to a lower dose than in group 2).