ANHL1522 Rituximab and Immune Cells from Donors to Treat PTLD - Clinical Trial
What is the Purpose of this Study?
We are doing this study to learn if we can improve the treatment for patients with PTLD by treating patients with special immune system cells called LMP-specific T cells.
These cells come from donors and are tested to find out which cells are a match for each patient.
Post-Transplant Lymphoproliferative Disease (PTLD)
Who Can Participate in the Study?
Children and young adults who:
- Are Age 29 or younger
- Have a history of solid organ transplantation
- Are newly diagnosed polymorphic or monomorphic PTLD
- Have measurable disease
- Recovered from previous chemotherapy, immunotherapy, or radiotherapy
What is Involved?
If you choose to be in this study, you will:
- Begin study treatment LMP-specific T cells (LMP-TC) with three doses of anti-B-cell medicine rituximab once a week for 21 days
- Get imaging scans to look at your tumor size
- After induction chemotherapy (first line of treatment for cancer), you will be put into one of the following groups:
A) Get another 21-day course of rituximab
B) Get either 1 or 2 six week courses of LMP-specific T cells