Self-activation of Reward-related Brain Regions in Cigarette Smokers - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn more about how reward and motivation work in people who smoke.

What is the Condition Being Studied?

Smoking (Nicotine Dependence)

Who Can Participate in the Study?

Adults ages 18-55 who:
- Are in good general health
- Smoke at least 5 traditional cigarettes per day (i.e., do not exclusively use e-cigarettes or vapes)
- Are not pregnant
- Are not claustrophobic
- Have no other contraindications to being in an MRI machine

For more information about who can be in this study, please contact the study team at or 919-681-4601.

Age Group

What is Involved?

If you choose to join this study, you will:
- Have a phone call with the study team to see if you are eligible
- Visit our clinic 2 or 3 times
- Fill out surveys
- Give a urine sample
- Have an MRI brain scan

Before your clinic visits, we will ask you to take or download pictures related to smoking and of things you enjoy (e.g., your pet, your favorite food, etc). This is a neurofeedback study, so you will be able to watch your own brain signals change while you are inside the MRI machine!

If you are interested, you can complete a pre-screening survey online:

Study Details

Full Title
Self-activation of Reward-related Brain Regions in Individuals with and without Nicotine Dependence.
Principal Investigator
Rachel Adcock
Protocol Number
IRB: PRO00081458
NCT: NCT03170258
Enrollment Status
Open for Enrollment
Contact the Duke Recruitment Innovation Center