The PRiME Study for Medulloblastoma and Glioma (Brain Cancer) - Clinical Trial

We are doing this study see if the PEP-CMV vaccine can help the immune system fight brain cancer.

Brain Cancer (World Health Organization [WHO] Grade III or IV glioma or medulloblastoma)

Children aged 3 to 17 years old with:
- WHO Grade III or IV glioma that has progressed or recurred.
- Medulloblastoma that has progressed or recurred

and

Adults aged 18 to 35 years old with:
- Medulloblastoma that has progressed or recurred

If you or your child choose to join this study, you or your child will:
- Have your blood tested for antibodies (substances produced by the body to fight infections) to a common virus called cytomegalovirus (CMV)
- Have standard radiation therapy with temozolomide chemotherapy before beginning study procedures
- Have blood drawn that is routine and blood drawn for research that will look at your immune system
- Get a Tetanus-diphtheria (Td) immunization shot before beginning study vaccines (given as a shot in the leg)
- Get PEP-CMV study vaccines every 2 weeks for the 1st 3 vaccines and then monthly thereafter