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Airway remodeling in obesity - AROA and Ancillary study (AROA-M19) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn more about the effect of weight loss on airway scarring in people who have asthma versus people who do not have asthma.
What is the Condition Being Studied?
Early-onset asthma

Who Can Participate in the Study?

Adults who:
- Have asthma or do not have asthma;
- Are at a healthy weight
- Are undergoing weight loss surgery
- Do not smoke

Age Group

What is Involved?

If you choose to join this study, you will:
- Have between 3-6 visits lasting 2-3 hours each
- Have breathing tests, allergy testing, and a bronchoscopy done
- Give blood and urine samples
- Be involved in the study for one year if you are having weight loss surgery or around 1 month if you are not having weight loss surgery

Study Details

Full Title
Contributing factors in the pathobiology of airway remodeling in obesity Airway remodeling in obesity - AROA Ancillary study: Matrix Metalloproteinase-19 as a Mediator of Airway Fibrosis in Obese Allergic Asthma
Principal Investigator
Protocol Number
IRB: PRO00077482
NCT: NCT03115632
Contact the Duke Recruitment Innovation Center