OT-15-001 ORBUS STELLAR Study - Ph 3 Eflornithine + Lomustine (Brain Cancer) - Clinical Trial
What is the Purpose of this Study?
Who Can Participate in the Study?
Adults who have been diagnosed with WHO Grade 3 anaplastic astrocytoma that progressed or recurred for the first time after standard radiation and chemotherapy
What is Involved?
If you choose to be in this study, you will:
- Be randomly (like a flip of a coin) assigned to one of two groups:
-- Group A will get eflornithine and lomustine
--- Complete a 6-week cycle and will repeat this cycle for a total of 2 years
--- Come to the clinic about every 3 months during the 2nd year
-- Group B will get lomustine only
--- Lomustine will be taken once every 6 weeks for up to 1 year
-- Come to the clinic about every 6 weeks for 6 months and then about every 10 weeks thereafter during the 1st year