Development of a Novel Transdiagnostic Intervention for Anhedonia - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn more about a new form of psychotherapy designed to treat anhedonia (difficulty feeling joy or pleasure and low motivation).
Anhedonia is a symptom of many mental conditions including anxiety, depression, PTSD and ADHD.  

What is the Condition Being Studied?

Anhedonia (difficulty feeling joy or pleasure and low motivation)

Who Can Participate in the Study?

Adults age 18-50 who:
- Are interested in receiving talk therapy for low motivation and difficulty feeling pleasure
- Do not currently take psychiatric medication
- Are not currently in psychotherapy
- Have no history of neurological conditions (for example, stroke, seizure, or concussions)
- Are able to safely have MRI scans (for example, no metal in the body or claustrophobia)  
- Have not used antidepressants, antipsychotics or mood stabilizers in the past 4 weeks.

Please contact the study team for more information about participating in the study.

Age Group

What is Involved?

If you choose to join this study, you will:

- Have a screening visit that may last up to 4 hours  
- Have up to 2 fMRIs (magnetic resonance imaging tests) at UNC's Biomedical Research Imaging Center
- Have up to 2 blood draws over the 15 weeks of the study

- Be randomized (like the flip of a coin) to receive one of two kinds of talk therapy
- Be asked to attend one-hour talk therapy sessions once a week at Duke University for 15 weeks  
- Be asked to fill out questionnaires about your health and how are feeling up to 5 times over the study  
- Be asked to complete computer tasks up to 5 times over the study  

Study Details

Full Title
Development of a Novel Transdiagnostic Intervention for Anhedonia
Principal Investigator
Clinical Psychologist
Protocol Number
IRB: PRO00076224
NCT: NCT02874534
Phase N/A
Enrollment Status
Open for Enrollment
Contact the Duke Recruitment Innovation Center