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MUA to Treat Postoperative Stiffness after TKA (Total Knee Arthroplast) - Clinical Trial

What is the Purpose of this Study?

We are doing this study the learn which is better for patients (manipulation under anesthesia (MUA) with and without anti-inflammatory medicines) who have stiffness after total knee replacement.
What is the Condition Being Studied?
Arthrofibrosis (stiffness) of the knee after primary total knee replacement

Who Can Participate in the Study?

Adults ages 18 to 90 having knee manipulation under anesthesia (MUA)

Age Group

What is Involved?

If you choose to join this study, you will
- Be randomly assigned (like the flip of a coin) to receive manipulation under anesthesia (MUA) with or without the anti-inflammatory medications celecoxib and dexamethasone.
- At your regular follow-up visits to the doctor's office at 6 weeks and 1 year after the MUA, the study team will ask you to complete study questionnaires and examine your knee.

Study Details

Full Title
Manipulation Under Anesthesia (MUA) to Treat Postoperative Stiffness after Total Knee Arthroplasty: A Multicenter Randomized Clinical Trial
Principal Investigator
Joint Replacement Surgeon
Protocol Number
IRB: PRO00073233
NCT: NCT02739035
Phase IV
Contact the Duke Recruitment Innovation Center