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PCORI PEPPER: Preventing Clots after Hip or Knee Replacement - Clinical Trial

What is the Purpose of this Study?

We are doing this study to improve health care after hip and knee replacement. All patients must be on an anticoagulant (blood thinner) after hip and knee replacement surgery. We want to better understand which blood thinners are best at preventing blood clots and which ones cause the least problems with bleeding.

What is the Condition Being Studied?

Preventing blood clots after Hip and Knee Replacement Surgeries

Who Can Participate in the Study?

Patients over 21 having elective hip and/or knee replacement surgery

Age Group
Adults

What is Involved?

If you choose to join this study, you will:

- Be randomized (like the flip of a coin) to get one of three regularly used oral blood thinner medications to be taken for 30 days after your surgery
-- Aspirin
-- Warfarin (Coumadin)
-- Rivaroxaban (Xarelto)
All of these drugs are approved for the prevention of blood clots. There are no experimental or investigational drugs being used in this study.

- There are no return visits needed for this study. You will be contacted 3 times over 6 months and asked some questions. You may choose to complete these questions by mail, phone, email, or online.

Study Details

Full Title
Comparative Effectiveness of Pulmonary Embolism Prevention after Hip and Knee Replacement (PEPPER): Balancing Safety and Effectiveness
Principal Investigator
Joint Replacement Surgeon
Protocol Number
IRB:PRO00072546
NCT:NCT02810704
Phase
Phase IV
ClinicalTrials.gov
Contact the Duke Recruitment Innovation Center
MyResearchPartners@duke.edu
or
919-681-5698