PCORI PEPPER: Preventing Clots after Hip or Knee Replacement - Clinical Trial
What is the Purpose of this Study?
We are doing this study to improve health care after hip and knee replacement. All patients must be on an anticoagulant (blood thinner) after hip and knee replacement surgery. We want to better understand which blood thinners are best at preventing blood clots and which ones cause the least problems with bleeding.
Preventing blood clots after Hip and Knee Replacement Surgeries
Who Can Participate in the Study?
Patients over 21 having elective hip and/or knee replacement surgery
What is Involved?
If you choose to join this study, you will:
- Be randomized (like the flip of a coin) to get one of three regularly used oral blood thinner medications to be taken for 30 days after your surgery
-- Warfarin (Coumadin)
-- Rivaroxaban (Xarelto)
All of these drugs are approved for the prevention of blood clots. There are no experimental or investigational drugs being used in this study.
- There are no return visits needed for this study. You will be contacted 3 times over 6 months and asked some questions. You may choose to complete these questions by mail, phone, email, or online.