LCZ696 or Enalapril for Children With Heart Failure - Clinical Trial
What is the Purpose of this Study?
We are doing this study is to find out if LCZ696 will be better than Enalapril in children with heart failure.
Heart Failure in Children
Who Can Participate in the Study?
- Are 1 month to 17 years old
- Have heart failure due to systemic left ventricle systolic dysfunction (the left side of your heart isn't working as well as it should)
What is Involved?
This study is divided into two parts.
If you decide to be in this study:
During Part 1, you will:
-- Take LCZ696 by mouth
-- Be divided into three groups depending on age (6-17 years, 12 months to less than 6 years, and 1 month to less than 1 year old) that will determine what dose of the study drug your child gets
After you finish Part 1, you will be asked if you are interested in joining Part 2.
In Part 2, you will:
-Be randomly assigned, like a flip of a coin, into one of two groups:
-- Group 1: Will take LCZ696 by mouth
-- Group 2: Will take Enalapril by mouth