Call your doctor before leaving home if you think you’ve been exposed to COVID-19 or have symptoms

Due to the presence of COVID-19 in our community, visitor restrictions are in place for all Duke clinics and hospitals. For your safety and the safety of others, we recommend patients do not bring a visitor to Duke clinics, if at all possible. If a visitor must accompany a patient, only one individual over 12 years of age is allowed. Patients and visitors will be screened for symptoms upon arrival. Individuals with flu-like symptoms are not allowed. View the complete list of Visitor Restrictions.

Effective immediately, Duke Health is prioritizing and rescheduling some non-emergent or non-critical surgeries, procedures, and appointments. Check our COVID-19 (Coronavirus) page for updates.

LCZ696-Heart Failure - Clinical Trial

What is the Purpose of this Study?

We are doing this study is to find out if LCZ696 will be better than Enalapril in children with heart failure.   
What is the Condition Being Studied?
Heart Failure in Children

Who Can Participate in the Study?

Children who:
 - Are 1 month to 17 years old
- Have heart failure due to systemic left ventricle systolic dysfunction (the left side of your heart isn't working as well as it should)

Age Group

What is Involved?

This study is divided into two parts.

If you decide to be in this study:

During Part 1, you will:
-- Take LCZ696 by mouth
-- Be divided into three groups depending on age (6-17 years, 12 months to less than 6 years, and 1 month to less than 1 year old) that will determine what dose of the study drug your child gets

After you finish Part 1, you will be asked if you are interested in joining Part 2.  
In Part 2, you will:
-Be randomly assigned, like a flip of a coin, into one of two groups:
-- Group 1: Will take LCZ696 by mouth
-- Group 2: Will take Enalapril by mouth

Study Details

Full Title
Multicenter, open-label, study to evaluate safety, tolerability and PD/PK of LCZ696 followed by a 52-week randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696 compared to enalapril in pediatric pa
Principal Investigator
Protocol Number
IRB: PRO00071235
NCT: NCT02678312
Phase II
Contact the Duke Recruitment Innovation Center