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Paracrine Effects on Insulin Secretion - Clinical Trial

What is the Purpose of this Study?

We are doing this study to look at the role of a naturally occurring hormone glucagon-like peptide (GLP-1) on insulin secretion and how this hormone helps control blood glucose levels. GLP-1 is released into the circulating blood after eating and helps to control the blood glucose levels by increasing insulin secretion by cells in the pancreas.

What is the Condition Being Studied?

Healthy Veterans and glucose control

Who Can Participate in the Study?

Veterans who:
- Are 20-45 years old
- Do NOT have diabetes

Age Group

What is Involved?

If you decide to volunteer and participate in the study, you will:
- Have 3 study visits over 3 to 6 weeks
- During Visits 2 and 3 you will:
-- Have an intravenous infusion to measure your blood sugar (glucose) in response to a synthetic peptide of amino acids.

An amino acid is the basic building block of protein. Almost every part of your body is made up of proteins. In the same way, repair, maintenance of cells and critical bio-chemical processes in the body are dependent on proteins.

Study Details

Full Title
Regulation of Insulin Secretion by the GLP-1 Receptor
Principal Investigator
Diabetes and Metabolism Specialist
Protocol Number
Phase IV
Contact the Duke Recruitment Innovation Center