HER2CLIMB/ ONT-380: Advanced HER2+ Breast Cancer - Clinical Trial
What is the Purpose of this Study?
We are doing this study is to see if the study drug tucatinib works better than placebo to help people who have HER2 positive breast cancer.
Advanced HER2+ Breast Cancer
Who Can Participate in the Study?
Adults who have HER2+ breast cancer and have gotten previous treatment with trastuzumab, pertuzumab, and T-DM1.
What is Involved?
If you choose to join this study, you will:
- Be randomized (like a flip of a coin) into one of two treatment groups:
-- Group 1 will get the study drug tucatinib, plus capecitabine and trastusumab.
-- Group 2 will get a placebo (a pill with no medicine), plus capecitebine and trastuzumab
- Have blood draws and physical exams during your regular office visits.