Exercise and Pharmacotherapy for Anxiety in Cardiac Patients - Clinical Trial
What is the Purpose of this Study?
We are doing this study to learn more about the effects of aerobic exercise and medication on symptoms of worry and stress in adults with coronary heart disease.
Heart disease with worry, stress, or tension
Who Can Participate in the Study?
Adults age 40 and older who:
- Have a history of heart disease (e.g., stent, heart attack, bypass graft, or angina)
- Have symptoms of worry, stress, tension, nervousness, panic, or anxiety
- Are not currently taking medication to enhance mood
- Are not currently in a formal exercise program
For more information about who can be in this study, please contact the study team.
What is Involved?
If you choose to join this study, you will:
- Have a screening visit that includes questionnaires, a physical, and an interview
- Have baseline pre-treatment procedures, like an exercise stress test, blood work, and an ultrasound of your blood vessels
- Be randomized (like flipping a coin) to one of three 12-week treatment groups:
--- Group 1: Exercise at a local cardiac rehab facility 3 days/week
--- Group 2: Medication pill (escitalopram (Lexapro)) taken daily plus 5 clinic visits
--- Group 3: Placebo pill (inactive like a sugar pill) taken daily plus 5 clinic visits
- Have post-treatment assessments, the same as you did during the screening visit
- Have one follow-up visit 6 months after the study, which involves questionnaires, an interview, and a walk test