SBRT In Early Stage Breast Cancer - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn about the cosmetic outcomes in breast cancer patients who are treated with this single dose of radiation.

This study will also help us learn about how breast cancer responds to radiation so that in the future, radiation can be matched to the patient's particular tumor.

What is the Condition Being Studied?

Early stage breast cancer

Who Can Participate in the Study?

Adults aged 50 years or older who:
- Are diagnosed with early stage breast cancer
- Have a tumor that measures less than or equal to 2cm
- Have a negative pregnancy test

Age Group

What is Involved?

If you join this study, you will:
- Have a MRI scan and CT scan to find the tumor and create a plan for your radiation treatment
- A single radiation dose of 21 Gy (Gray) will be given to your breast cancer.
- Surgery will be done to remove your tumor, within 10 days of finishing radiation.
- We will obtain tumor tissue from your surgery to understand how breast cancer responds to radiation.
- We will take digital photographs and ask you to fill out quality of life questionnaires before the single radiation dose and at 6 months, 1 year, 2 years and 3 years after treatment.
-- The photographs will be used to see how your breasts look before and after surgery and radiation treatment.

Study Details

Full Title
A Phase II Evaluation of Preoperative Single-Fraction Partial Breast Radiotherapy in Early Stage Breast Cancer
Principal Investigator
Radiation Oncologist
Protocol Number
IRB: PRO00063848
NCT: NCT02482376
Phase II
Enrollment Status
Open for Enrollment
Contact the Duke Recruitment Innovation Center