(MRZ-108) Triphase Marizomib for Malignant Glioma - Clinical Trial
What is the Purpose of this Study?
We are doing this study to find out if a drug called Marizomib (MRZ) has an effect (good or bad) in patients with brain cancer that has come back after initial treatment.
We also want to find out what is the most tolerable and safest dose that can be given when MRZ is given through a tube that goes through your nose to your stomach (known as a nasogastric or NG tube) when the standard dose of Bevacizumab (BEV) is also given to you.
Brain Cancer (Grade IV Malignant Glioma)
Who Can Participate in the Study?
- Have been diagnosed with Grade IV Glioma (Glioblastoma or Gliosarcoma) that has come back or continued to grow after treatment with radiation therapy and chemotherapy (temozolomide)
- Have not had prior treatment with Bevacizumab (Avastin)
What is Involved?
If you agree to be in this study, you will:
- Get treatment in 28 day cycles
-- Marizomib will be given to you through a tube through your nose into your stomach
-- Bevacizumab will be given to you through an IV
-- Additional cycles of the study drugs may be given to you depending on your response to the therapy
- Have other tests (physical exams, lab tests, and scans) to track your progress and record any side effects that you may have in reaction to the study drugs