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D2C7 (Glioma) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn how much drug (D2C7-immunotoxin) can be safely given to people with malignant gliomas that have progressed or recurred

What is the Condition Being Studied?

Grade III or IV malignant glioma (brain tumor) that has progressed or recurred

Who Can Participate in the Study?

Adult men and women who:
- Are diagnosed with recurrent WHO Grade III or IV malignant glioma
- Are able to have an MRI (magnetic resonance imaging)
- Do not have an allergy to gadolinium contrast agents
- Are not in active treatment for other, unrelated types of cancer, except for cervical cancer or squamous cell cancer.

Please contact the study team for more detailed information.

Age Group
Adults

What is Involved?

If you agree to take part in this study, you will:
- Have a brain biopsy to determine the type of recurrent tumor you have
- Stay in the hospital and have a catheter inserted into the tumor location
- Receive an investigational drug (D2C7-immunotoxin) delivered directly into your brain tumor
- Have several tests and procedures including medical history, physical exam, and blood tests
- Have post-infusion clinic visits

Study Details

Full Title
Phase I Single-Center, Dose Escalation Study of D2C7-IT Administered Intratumorally via Convection-Enhanced Delivery for Adult Patients with Recurrent Malignant Glioma
Principal Investigator
Neuro-oncologist
Protocol Number
IRB:PRO00053325
NCT:NCT02303678
Phase
Phase I
ClinicalTrials.gov
Contact the Duke Recruitment Innovation Center
MyResearchPartners@duke.edu
or
919-681-5698