Duke Asthma, Allergy, and Airway Center participates in clinical trials to examine new medical approaches and increase scientific understanding of various asthma and allergy conditions and treatments.

If you have any questions about research studies, please contact your physician. For clinical trial opportunities in other areas, please see DukeHealth.org's Clinical Trials.

• A Study Comparing Measures of Ventilatory Heterogeneity (VH) in Asthma Patients
  This is a 3-period, non-randomized study in patients with either mild asthma (exercise induced or currently maintained on Step I / II medications [NAEPP guidelines]) or moderate/severe asthma (NAEPP clinical profile with Step III-IV medication use) and a history of clinical exacerbations to evaluate Oe 1H- and 19F-MRI as treatment response biomarkers in future clinical trials. This study will also assess the reproducibility of both MRI measurements to determine their utility as enhanced functional pulmonary biomarkers, and a window into their predictive value for exacerbations will be obtained through the use of a post-study clinical review at 6 months following study completion
• SAPS Study - Smoking Asthmatics Pilot Study
  The Duke Clinical Research Unit is recruiting asthma patients who also smoke to take part in a research study. the study will examine whether questionnaires used to evaluate asthma symptoms in non-smokers can also be applied to people with asthma who smoke.
• Asthma Patient Registry
  The Duke Clinical Research Unit is enrolling people with asthma into the American Lung Association's Asthma Clinical Research Center patient registry.
• Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients with Asthma
  Asthma patients who do not smoke and have been using medication for at least a year are needed to take part in a research study at the Duke Clinical Research Unit.
• Long-Acting Beta Agonist Step Down Study (LASST)
  Males and females, age 12 years and older are needed to participate in a research study to evaluate the optimal treatment strategy for reducing therapy in people with asthma.
• Airway Remodeling in Asthma: Modulation by IL-13
  Researchers seek adult non-smokers with asthma to participate in this study.
• GSNO Reductase, S-nitrosothiols, and Asthma
  Researchers are seeking adult non-smokers with asthma for participation in this study.
• Surfactant Protein A Regulation of Innate Immunity in Asthma
  Researchers seek adult non-smokers with asthma for participation in this study.
• Vitamin D Add-On Therapy Enhances Corticosteriod Responsiveness in Asthma (VIDA)
  Researchers seek adults with asthma and low vitamin D levels for participation in this study.
• Small Airways in Asthmatics
  Duke Asthma and Airway Center is conducting a study to determine if there is a difference between the small airway in elderly people with asthma compared to younger adults with and without asthma.