Physicians

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC 102365
Durham, NC 27710

Appointment Telephone
919-668-7630

Office Telephone
919-681-3394

Fax Telephone
919-684-3199

Training

• MD, National Taiwan University College of Medicine, 1983

Residency

• Medicine, Maryland General Hospital, 1988

Fellowship

• Pulmonary and Critical Care Medicine, Duke University Medical Center, 1991

Other Training

• MHS, Environmental Health Sciences, Johns Hopkins University (Maryland), 1984

Clinical Interests
Asthma, COPD, sepsis, hereditary hemorrhagic telengiectasia, environmental medicine

Research Interests
Long-term oxygen in COPD
COPDGene
Closed loop ventilation
Environmental medicine
Oxidative lung injury

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Huang, YC; Karoly, ED; Dailey, LA; Schmitt, MT; Silbajoris, R; Graff, DW; Devlin, RB. Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. Journal of Toxicology and Environmental Health Part A. 2011;74:296-312. (2011) Abstract

Huang, YC; Schmitt, M; Yang, Z; Que, LG; Stewart, JC; Frampton, MW; Devlin, RB. Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. Inhalation Toxicology. 2010;22:835-846. (2010) Abstract

Wu, CP; Lin, HI; Perng, WC; Yang, SH; Chen, CW; Huang, YC; Huang, KL. Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failure. Respiratory Care: a monthly science journal. 2010;55:334-341. (2010) Abstract

Graff, DW; Cascio, WE; Rappold, A; Zhou, H; Huang, YC; Devlin, RB. Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. Environmental Health Perspectives. 2009;117:1089-1094. (2009) Abstract

Huang, YC; Ghio, AJ. Controlled human exposures to ambient pollutant particles in susceptible populations. Environmental Health: A Global Access Science Source. 2009;8:33. (2009) Abstract

Huang, YC; Li, Z; Carter, JD; Soukup, JM; Schwartz, DA; Yang, IV. Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology. 2009;41:544-552. (2009) Abstract

Samet, JM; Rappold, A; Graff, D; Cascio, WE; Berntsen, JH; Huang, YC; Herbst, M; Bassett, M; Montilla, T; Hazucha, MJ; Bromberg, PA; Devlin, RB. Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers. American Journal of Respiratory and Critical Care Medicine. 2009;179:1034-1042. (2009) Abstract

Chien, JY; Lin, MS; Huang, YC; Chien, YF; Yu, CJ; Yang, PC. Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial. Critical Care Medicine. 2008;36:1421-1426. (2008) Abstract

Huang, YC. Lung compliance measurement in mice. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2008;294:L815. (2008) Abstract

Huang, YC; Li, Z; Hyseni, X; Schmitt, M; Devlin, RB; Karoly, ED; Soukup, JM. Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line. Genomic Medicine. 2008;2:113-125. (2008) Abstract

MacIntyre, N; Huang, YC. Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2008;5:530-535. (2008) Abstract

Karoly, ED; Li, Z; Dailey, LA; Hyseni, X; Huang, YC. Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure. Environmental Health Perspectives. 2007;115:535-540. (2007) Abstract

Yang, LY; Huang, YC; Macintyre, NR. Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation. Journal of Critical Care. 2007;22:252-257. (2007) Abstract

Huang, YC; Bassett, MA; Levin, D; Montilla, T; Ghio, AJ. Acute phase reaction in healthy volunteers after bronchoscopy with lavage. Chest. 2006;129:1565-1569. (2006) Abstract

Huang, YC; Ghio, AJ. Vascular effects of ambient pollutant particles and metals. Current and Vascular Pharmacology. 2006;4:199-203. (2006) Abstract

Li, Z; Hyseni, X; Carter, JD; Soukup, JM; Dailey, LA; Huang, YC. Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. American Journal of Physiology: Cell Physiology. 2006;291:C357-C365. (2006) Abstract

Arredouani, MS; Palecanda, A; Koziel, H; Huang, YC; Imrich, A; Sulahian, TH; Ning, YY; Yang, Z; Pikkarainen, T; Sankala, M; Vargas, SO; Takeya, M; Tryggvason, K; Kobzik, L. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. Journal of Immunology. 2005;175:6058-6064. (2005) Abstract

Becker, S; Dailey, LA; Soukup, JM; Grambow, SC; Devlin, RB; Huang, YC. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environmental Health Perspectives. 2005;113:1032-1038. (2005) Abstract

Huang, YC. Monitoring oxygen delivery in the critically ill. Chest. 2005;128:554S-560S. (2005) Abstract

Huang, YC; Li, Z; Brighton, LE; Carson, JL; Becker, S; Soukup, JM. 3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2005;288:L988-L996. (2005) Abstract

Lee, DL; Hsu, CW; Lee, H; Chang, HW; Huang, YC. Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation. Academic Emergency Medicine. 2005;12:820-827. (2005) Abstract

Lee, DL; Lee, H; Chang, HW; Chang, AY; Lin, SL; Huang, YC. Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations. Critical Care Medicine. 2005;33:968-973. (2005) Abstract

Li, Z; Carter, JD; Dailey, LA; Huang, YC. Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. Environmental Health Perspectives. 2005;113:1009-1014. (2005) Abstract

Li, Z; Stonehuerner, J; Devlin, RB; Huang, YC. Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. Environmental Health Perspectives. 2005;113:1747-1754. (2005) Abstract

McMahon, TJ; Ahearn, GS; Moya, MP; Gow, AJ; Huang, YC; Luchsinger, BP; Nudelman, R; Yan, Y; Krichman, AD; Bashore, TM; Califf, RM; Singel, DJ; Piantadosi, CA; Tapson, VF; Stamler, JS. A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. Proceedings of the National Academy of Sciences of USA. 2005;102:14801-14806. (2005) Abstract

Ghio, AJ; Huang, YC. Exposure to concentrated ambient particles (CAPs): a review. Inhalation Toxicology. 2004;16:53-59. (2004) Abstract

Huang, YC; Li, Z; Harder, SD; Soukup, JM. Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. Inhalation Toxicology. 2004;16:863-878. (2004) Abstract

Kotani, M; Kotani, T; Ishizaka, A; Fujishima, S; Koh, H; Tasaka, S; Sawafuji, M; Ikeda, E; Moriyama, K; Kotake, Y; Morisaki, H; Aikawa, N; Ohashi, A; Matsushima, K; Huang, YC; Takeda, J. Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung. Critical Care Medicine. 2004;32:514-519. (2004) Abstract

Kotani, M; Kotani, T; Li, Z; Silbajoris, R; Piantadosi, CA; Huang, YC. Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. European Respiratory Journal. 2004;24:238-246. (2004) Abstract

Li, Z; Carter, JD; Dailey, LA; Huang, YC. Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS. Environmental Health Perspectives. 2004;112:201-206. (2004) Abstract

Huang, YC; Ghio, AJ; Stonehuerner, J; McGee, J; Carter, JD; Grambow, SC; Devlin, RB. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhalation Toxicology. 2003;15:327-342. (2003) Abstract

Huang, YC; Soukup, J; Harder, S; Becker, S. Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. American Journal of Physiology: Cell Physiology. 2003;284:C24-C32. (2003) Abstract