Physicians

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC 102365
Durham, NC 27710

Appointment Telephone
919-668-7630

Office Telephone
919-681-3394

Fax Telephone
919-684-3199

Training

• MD, National Taiwan University College of Medicine, 1983

Residency

• Medicine, Maryland General Hospital, 1988

Fellowship

• Pulmonary and Critical Care Medicine, Duke University Medical Center, 1991

Other Training

• MHS, Environmental Health Sciences, Johns Hopkins University (Maryland), 1984

Clinical Interests
Asthma, COPD, sepsis, hereditary hemorrhagic telengiectasia, environmental medicine

Research Interests
Long-term oxygen in COPD
COPDGene
Closed loop ventilation
Environmental medicine
Oxidative lung injury

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Huang YC, Karoly ED, Dailey LA, Schmitt MT, Silbajoris R, Graff DW, Devlin RB. Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. J Toxicol Environ Health A. 2011;74(5):296-312. (2011) Abstract

Huang YC, Schmitt M, Yang Z, Que LG, Stewart JC, Frampton MW, Devlin RB. Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. Inhal Toxicol. 2010 Aug;22(10):835-46. (2010) Abstract

Wu CP, Lin HI, Perng WC, Yang SH, Chen CW, Huang YC, Huang KL. Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failure.  Respir Care.  2010 Mar;55(3):334-41. (2010) Abstract

Auten RL, E Potts, SN Mason, B Fischer, YC Huang and WM Foster. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. Am J Respir Crit Care Med, 180(12):1218-1226, 2009 (2009)

Graff DW, Cascio WE, Rappold A, Zhou H, Huang YC, Devlin RB. Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. Environ Health Perspect. 2009 Jul;117(7):1089-94. (2009) Abstract

Huang YC, Ghio AJ. Controlled human exposures to ambient pollutant particles in susceptible populations. Environ Health. 2009;8:33. (2009) Abstract

Huang YC, Li Z, Carter JD, Soukup JM, Schwartz DA, Yang IV. Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. Am J Respir Cell Mol Biol. 2009 Nov;41(5):544-52. (2009) Abstract

Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, Herbst M, Bassett M, Montilla T, Hazucha MJ, Bromberg PA, Devlin RB. Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers. Am J Respir Crit Care Med. 2009 Jun 1;179(11):1034-42. (2009) Abstract

Chien JY, Lin MS, Huang YC, Chien YF, Yu CJ, Yang PC. Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial. Crit Care Med. 2008 May;36(5):1421-6. (2008) Abstract

Huang YC, Li Z, Hyseni X, Schmitt M, Devlin RB, Karoly ED, Soukup JM. Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line. Genomic Med. 2008 Dec;2(3-4):113-25. (2008) Abstract

Huang YC. Lung compliance measurement in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Apr;294(4):L815; author reply L816. (2008) Abstract

MacIntyre N, Huang YC. Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008 May 1;5(4):530-5. (2008) Abstract

Karoly ED, Li Z, Dailey LA, Hyseni X, Huang YC. Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure. Environ Health Perspect. 2007 Apr;115(4):535-40. (2007) Abstract

Karoly ED, Li ZW, Dailey LA, Hyseni X, Samet JM, Huang YC. Transcriptional profiling in human pulmonary artery endothelial cells following ultrafine particle exposure. Environ Health Perspect. 2007, 115: 535-540. (2007)

Yang LY, Huang YC, Macintyre NR. Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation. J Crit Care. 2007 Sep;22(3):252-7. (2007) Abstract

Huang YC, Bassett MA, Levin D, Montilla T, Ghio AJ. Acute phase reaction in healthy volunteers after bronchoscopy with lavage. Chest. 2006 Jun;129(6):1565-9. (2006) Abstract

Huang YC, Ghio AJ. Vascular effects of ambient pollutant particles and metals. Curr Vasc Pharmacol. 2006 Jul;4(3):199-203. (2006) Abstract

Li Z, Hyseni X, Carter JD, Soukup JM, Dailey LA, Huang YC. Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol. 2006 Aug;291(2):C357-65. (2006) Abstract

Arredouani MS, Palecanda A, Koziel H, Huang YC, Imrich A, Sulahian TH, Ning YY, Yang Z, Pikkarainen T, Sankala M, Vargas SO, Takeya M, Tryggvason K, Kobzik L. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol. 2005 Nov 1;175(9):6058-64. (2005) Abstract

Becker S, Dailey LA, Soukup JM, Grambow SC, Devlin RB, Huang YC. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ Health Perspect. 2005 Aug;113(8):1032-8. (2005) Abstract

Huang YC, Li Z, Brighton LE, Carson JL, Becker S, Soukup JM. 3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line. Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L988-96. (2005) Abstract

Huang YC. Monitoring oxygen delivery in the critically ill. Chest. 2005 Nov;128(5 Suppl 2):554S-560S. (2005) Abstract

Lee DL, Hsu CW, Lee H, Chang HW, Huang YC. Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation. Acad Emerg Med. 2005 Sep;12(9):820-7. (2005) Abstract

Lee DL, Lee H, Chang HW, Chang AY, Lin SL, Huang YC. Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations. Crit Care Med. 2005 May;33(5):968-73. (2005) Abstract

Li Z, Carter JD, Dailey LA, Huang YC. Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. Environ Health Perspect. 2005 Aug;113(8):1009-14. (2005) Abstract

Li Z, Stonehuerner J, Devlin RB, Huang YC. Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. Environ Health Perspect. 2005 Dec;113(12):1747-54. (2005) Abstract

McMahon TJ, Ahearn GS, Moya MP, Gow AJ, Huang YC, Luchsinger BP, Nudelman R, Yan Y, Krichman AD, Bashore TM, Califf RM, Singel DJ, Piantadosi CA, Tapson VF, Stamler JS. A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14801-6. (2005) Abstract

Ghio AJ, Huang YC. Exposure to concentrated ambient particles (CAPs): a review. Inhal Toxicol. 2004 Jan;16(1):53-9. (2004) Abstract

Huang YC, Li Z, Harder SD, Soukup JM. Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. Inhal Toxicol. 2004 Dec 15;16(14):863-78. (2004) Abstract

Kotani M, Kotani T, Ishizaka A, Fujishima S, Koh H, Tasaka S, Sawafuji M, Ikeda E, Moriyama K, Kotake Y, Morisaki H, Aikawa N, Ohashi A, Matsushima K, Huang YC, Takeda J. Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung. Crit Care Med. 2004 Feb;32(2):514-9. (2004) Abstract

Kotani M, Kotani T, Li Z, Silbajoris R, Piantadosi CA, Huang YC. Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. Eur Respir J. 2004 Aug;24(2):238-46. (2004) Abstract

Li Z, Carter JD, Dailey LA, Huang YC. Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS. Environ Health Perspect. 2004 Feb;112(2):201-6. (2004) Abstract

Huang YC, Ghio AJ, Stonehuerner J, McGee J, Carter JD, Grambow SC, Devlin RB. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal Toxicol. 2003 Apr 11;15(4):327-42. (2003) Abstract

Huang YC, Soukup J, Harder S, Becker S. Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. Am J Physiol Cell Physiol. 2003 Jan;284(1):C24-32. (2003) Abstract