Department / Division:
Medicine / Pulmonary, Allergy, and Critical Care Medicine

Address:
DUMC 2733
Durham, NC 27710

Appointment Telephone:
919-668-7630 or 620-7300

Office Telephone:
919-681-3394

Fax Telephone:
919-684-3199

• MD, National Taiwan University College of Medicine, 1983

• Medicine, Maryland General Hospital, 1988

• Pulmonary and Critical Care Medicine, Duke University Medical Center, 1991

• MHS, Environmental Health Sciences, Johns Hopkins University (Maryland), 1984

Clinical Interests:
Asthma, COPD, sepsis, hereditary hemorrhagic telengiectasia, environmental medicine

Research Interests:
Long-term oxygen in COPD
COPDGene
Closed loop ventilation
Cardiopulmonary health effects of pollutant particles
Oxidative lung injury (mechanical ventilation, genomics, sepsis)

Representative Publications:
Karoly ED, Li ZW, Dailey LA, Hyseni X, Samet JM, Huang YC. Transcriptional profiling in human pulmonary artery endothelial cells following ultrafine particle exposure. Environ Health Perspect. 2007, 115: 535-540. (2007)

Li Z, Hyseni X, Carter JD, Soukup JM, Dailey LA, Huang YC. Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol. 2006 Aug;291(2):C357-65. (2006) Abstract

Huang YC, Ghio AJ. Vascular effects of ambient pollutant particles and metals. Curr Vasc Pharmacol. 2006 Jul;4(3):199-203. (2006) Abstract

Li Z, Stonehuerner J, Devlin RB, Huang YC. Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. Environ Health Perspect. 2005 Dec;113(12):1747-54. (2005) Abstract

Li Z, Carter JD, Dailey LA, Huang YC. Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. Environ Health Perspect. 2005 Aug;113(8):1009-14. (2005) Abstract

Lee DL, Lee H, Chang HW, Chang AY, Lin SL, Huang YC. Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations. Crit Care Med. 2005 May;33(5):968-73. (2005) Abstract

Lee DL, Hsu CW, Lee H, Chang HW, Huang YC. Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation. Acad Emerg Med. 2005 Sep;12(9):820-7. (2005) Abstract

Huang YC. Monitoring oxygen delivery in the critically ill. Chest. 2005 Nov;128(5 Suppl 2):554S-560S. (2005) Abstract

Becker S, Dailey LA, Soukup JM, Grambow SC, Devlin RB, Huang YC. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ Health Perspect. 2005 Aug;113(8):1032-8. (2005) Abstract

Li Z, Carter JD, Dailey LA, Huang YC. Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS. Environ Health Perspect. 2004 Feb;112(2):201-6. (2004) Abstract

Kotani M, Kotani T, Li Z, Silbajoris R, Piantadosi CA, Huang YC. Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. Eur Respir J. 2004 Aug;24(2):238-46. (2004) Abstract

Huang YC, Li Z, Harder SD, Soukup JM. Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. Inhal Toxicol. 2004 Dec 15;16(14):863-78. (2004) Abstract

Ghio AJ, Huang YC. Exposure to concentrated ambient particles (CAPs): a review. Inhal Toxicol. 2004 Jan;16(1):53-9. (2004) Abstract

Huang YC, Soukup J, Harder S, Becker S. Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. Am J Physiol Cell Physiol. 2003 Jan;284(1):C24-32. (2003) Abstract

Huang YC, Ghio AJ, Stonehuerner J, McGee J, Carter JD, Grambow SC, Devlin RB. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal Toxicol. 2003 Apr 11;15(4):327-42. (2003) Abstract