Physicians

Director, Pediatric Blood and Marrow Transplant Fellowship Program

Department / Division
Pediatrics / Pediatric-Blood & Marrow Transplantation

Address
DUMC 3350
Durham, NC 27710

Appointment Telephone
919-668-1100

Office Telephone
919-668-0442

Fax Telephone
919-668-1180

Training

• MD (Pediatrics), University of Delhi (India), 1986
• MBBS, University of Delhi (India), 1983
• University of Delhi Pediatrics Training (India), 1984-1989

Residency

• Member, Royal College of Physicians (United Kingdom), 1990
• Pediatric Hematology-Oncology, Hammersmith Hospital and Hospital for Sick Children and Saint James University Hospital (United Kingdom), 1990-1993

Fellowship

• Pediatric Hematology, Oncology, and Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center and Cornell University Medical Center (New York), 1994-1997

Clinical Interests
Cord-blood, stem-cell, and bone-marrow transplant for childhood cancers; inherited metabolic disorders; immunodeficiency; hemoglobinopathies and other serious diseases; histocompatibility (tissue typing) and other determinants of alloreactivity, with a focus on identifying the best-matched donors by using cutting-edge molecular techniques; post-transplant viral infections, with a focus on early detection and treatment

Research Interests
1. Expanding the role of umbilical cord blood transplants for inherited metabolic disorders.
2. Impact of histocompatibility and other determinants of alloreactivity on clinical outcomes of unrelated cord blood transplants.
3. Studies to analyse the impact of Killer Immunoglobulin receptors on the outcomes of hematopoietic stem cell transplantation utilizing haploidentical, CD34 selected, familial grafts.
4. Propective longitudinal study of serial monitoring of adenovirus in allogenic transpants(SMAART)patients.
5. Use of mesenchymal stem cells for the treatment of GVHD

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Boelens, JJ; Rocha, V; Aldenhoven, M; Wynn, R; O'Meara, A; Michel, G; Ionescu, I; Parikh, S; Prasad, VK; Szabolcs, P; Escolar, M; Gluckman, E; Cavazzana-Calvo, M; Kurtzberg, J; EUROCORD, Inborn error Working Party of EBMT and Duke University. Risk factor analysis of outcomes after unrelated cord blood transplantation in patients with hurler syndrome. Biology of Blood and Marrow Transplantation. 2009;15:618-625. (2009) Abstract

Parikh, SH; Mendizabal, A; Martin, PL; Prasad, VK; Szabolcs, P; Driscoll, TA; Kurtzberg, J. Unrelated donor umbilical cord blood transplantation in pediatric myelodysplastic syndrome: a single-center experience. Biology of Blood and Marrow Transplantation. 2009;15:948-955. (2009) Abstract

Hollingsworth, CL; Frush, DP; Kurtzburg, J; Prasad, VK. Pediatric hematopoietic stem cell transplantation and the role of imaging. Radiology. 2008;248:348-365. (2008) Abstract

Kurtzberg, J; Prasad, VK; Carter, SL; Wagner, JE; Baxter-Lowe, LA; Wall, D; Kapoor, N; Guinan, EC; Feig, SA; Wagner, EL; Kernan, NA; COBLT Steering Committee. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008;112:4318-4327. (2008) Abstract

Page, KM; Mendizabal, AM; Prasad, VK; Martin, PL; Parikh, S; Wood, S; Sempowski, GD; Szabolcs, P; Kurtzberg, J. Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation. Biology of Blood and Marrow Transplantation. 2008;14:1108-1117. (2008) Abstract

Prasad, VK; Kurtzberg, J. Emerging trends in transplantation of inherited metabolic diseases. Bone Marrow Transplantation. 2008;41:99-108. (2008) Abstract

Prasad, VK; Mendizabal, A; Parikh, SH; Szabolcs, P; Driscoll, TA; Page, K; Lakshminarayanan, S; Allison, J; Wood, S; Semmel, D; Escolar, ML; Martin, PL; Carter, S; Kurtzberg, J. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood. 2008;112:2979-2989. (2008) Abstract

Beam, D; Poe, MD; Provenzale, JM; Szabolcs, P; Martin, PL; Prasad, V; Parikh, S; Driscoll, T; Mukundan, S; Kurtzberg, J; Escolar, ML. Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy. Biology of Blood and Marrow Transplantation. 2007;13:665-674. (2007) Abstract

Parikh, SH; Szabolcs, P; Prasad, VK; Lakshminarayanan, S; Martin, PL; Driscoll, TA; Kurtzberg, J. Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation. Pediatric Blood and Cancer. 2007;49:982-984. (2007) Abstract

Seo, SK; Regan, A; Cihlar, T; Lin, DC; Boulad, F; George, D; Prasad, VK; Kiehn, TE; Polsky, B. Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance. Clinical Infectious Diseases. 2001;33:e105-e108. (2001) Abstract

Antunes, NL; Boulad, F; Prasad, V; Rosenblum, M; Lis, E; Souweidane, M. Rolandic encephalopathy and epilepsia partialis continua following bone marrow transplant. Bone Marrow Transplantation. 2000;26:917-919. (2000) Abstract

Boulad, F; Gillio, A; Small, TN; George, D; Prasad, V; Torok-Castanza, J; Regan, AD; Collins, N; Auerbach, AD; Kernan, NA; O'Reilly, RJ. Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts. British Journal of Haematology. 2000;111:1153-1157. (2000) Abstract

Prasad, VK; Heller, G; Kernan, NA; O'Reilly, RJ; Yang, SY. The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles. Transplantation. 1999;68:1044-1050. (1999) Abstract

Prasad, VK; Kernan, NA; Heller, G; O'Reilly, RJ; Yang, SY. DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. Blood. 1999;93:399-409. (1999) Abstract

Prasad, VK; Kernan, NA; Heller, G; O'Reilly, RJ; Yang, SY. HLA-C disparity between patients and unrelated donors matched for HLA-A, -B, and -DRB1 alleles: impact of serological vs. DNA typing for HLA-A and -B loci. Biology of Blood and Marrow Transplantation. 1999;5:77-85. (1999) Abstract

Prasad, VK; Kim, IK; Farrington, K; Bussel, JB. TTP following ITP in an HIV-positive boy. Journal of Pediatric Hematology/Oncology. 1996;18:384-386. (1996) Abstract

Prasad, VK; Lewis, IJ; Aparicio, SR; Heney, D; Hale, JP; Bailey, CC; Kinsey, SE. Progressive glomerular toxicity of ifosfamide in children. Pediatric Blood and Cancer. 1996;27:149-155. (1996) Abstract

Prasad, VK; Yang, SY. Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines. Tissue Antigens: immune response genetics. 1996;47:538-546. (1996) Abstract

Prasad, VK; Aronson, DC; Gerald, WL; Meyers, PA; La Quaglia, MP. Hepatic focal nodular hyperplasia in infant antenatally exposed to steroids. Lancet. 1995;346:371. (1995) Abstract

McClure, RJ; Prasad, VK; Brocklebank, JT. Treatment of hyperkalaemia using intravenous and nebulised salbutamol. Archives of Disease in Childhood. 1994;70:126-128. (1994) Abstract

Prasad, VK; Corlett, SA; Abaasi, K; Heney, D; Lewis, I; Chrystyn, H. Ifosfamide enantiomers: pharmacokinetics in children. Cancer Chemotherapy and Pharmacology. 1994;34:447-449. (1994) Abstract

Kumar, H; Aneja, S; Prasad, VK; Arora, SK; Mullick, DN. Tetanus neonatorum: clinico-epidemiological profile. Indian Pediatrics. 1988;25:1054-1057. (1988) Abstract