Thomas M. Price, MD
Interim Chief, Reproductive Endocrinology and Fertility
Department / Division
Obstetrics/Gynecology /
Reproductive Endocrinology & Fertility
Address
5704 Fayetteville Road
Durham, NC 27713
2406 Blue Ridge Road, Suite 200
Raleigh, NC 27607
Appointment Telephone
919-572-4673
Office Telephone
919-572-4673
Fax Telephone
919-484-0461
- MD, University of North Carolina–Chapel Hill School of Medicine, 1984
- OB-GYN, UNC Hospitals, 1989
- Reproductive Endocrinology, University of Texas Southwestern Medical Center, 1991
Clinical Interests
Assisted reproduction technologies, recurrent pregnancy loss, reproductive tract abnormalities, polycystic ovary syndrome, endometriosis, uterine fibroids, robotic surgery
Research Interests
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
This faculty member has no reported relationships with industry.
Representative Publications
Gavrilova-Jordan, LP; Price, TM. Actions of steroids in mitochondria. Seminars in Reproductive Medicine. 2007;25:154-164.
(2007)
Abstract
Younglai, EV; Wu, Y; Foster, WG; Lobb, DK; Price, TM. Binding of progesterone to cell surfaces of human granulosa-lutein cells. The Journal of Steroid Biochemistry and Molecular Biology. 2006;101:61-67.
(2006)
Abstract
Price, TM; Hansen, EL; Oliver, TN. Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression. Journal of the Society for Gynecologic Investigation. 2005;12:610-616.
(2005)
Abstract
Saner, KJ; Welter, BH; Zhang, F; Hansen, E; Dupont, B; Wei, Y; Price, TM. Cloning and expression of a novel, truncated, progesterone receptor. Molecular and Cellular Endocrinology. 2003;200:155-163.
(2003)
Abstract
Welter, BH; Hansen, EL; Saner, KJ; Wei, Y; Price, TM. Membrane-bound progesterone receptor expression in human aortic endothelial cells. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology. 2003;51:1049-1055.
(2003)
Abstract
Welter, BH; Price, TM. Magnetic separation to concentrate the estrogen receptor from adipose tissue for western analysis. BioTechniques: the journal of laboratory technology for bioresearch. 1999;27:282-286.
(1999)
Abstract
O'Brien, SN; Welter, BH; Mantzke, KA; Price, TM. Identification of progesterone receptor in human subcutaneous adipose tissue. Journal of Clinical Endocrinology and Metabolism. 1998;83:509-513.
(1998)
Abstract
Price, TM; O'Brien, SN; Welter, BH; George, R; Anandjiwala, J; Kilgore, M. Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution. American Journal of Obstetrics and Gynecology. 1998;178:101-107.
(1998)
Abstract
O'Brien, SN; Anandjiwala, J; Price, TM. Differences in the estrogen content of breast adipose tissue in women by menopausal status and hormone use. Obstetrics and Gynecology. 1997;90:244-248.
(1997)
Abstract
Price, TM; Blauer, KL; Hansen, M; Stanczyk, F; Lobo, R; Bates, GW. Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol. Obstetrics and Gynecology. 1997;89:340-345.
(1997)
Abstract
O'Brien, SN; Mantzke, KA; Kilgore, MW; Price, TM. Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue. Cellular Oncology. 1996;18:137-143.
(1996)
Abstract
Price, TM; Dupuis, RE; Carr, BR; Stanczyk, FZ; Lobo, RA; Droegemueller, W. Single- and multiple-dose pharmacokinetics of a low-dose oral contraceptive in women with chronic renal failure undergoing peritoneal dialysis. American Journal of Obstetrics and Gynecology. 1993;168:1400-1406.
(1993)
Abstract
Price, TM; O'Brien, SN. Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification. Journal of Clinical Endocrinology and Metabolism. 1993;77:1041-1045.
(1993)
Abstract
