Thomas M. Coffman, MD
Chief, Division of Nephrology
Departments / Divisions- Medicine / Medicine-Nephrology
- Cell Biology
- Immunology
Address
DUMC 103015
Durham, NC 27710
Appointment Telephone
919-684-9788
Office Telephone
919-684-9788
Fax Telephone
919-684-3011
- MD, Ohio State University College of Medicine, 1980
- Medicine, Duke University Medical Center, 1980-1983
- Nephrology, Duke University Medical Center, 1983-1985
Clinical Interests
Renal transplantation, hypertension
Research Interests
My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.
This faculty member has no reported relationships with industry.
Representative Publications
Facemire, CS; Griffiths, R; Audoly, LP; Koller, BH; Coffman, TM. The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. Hypertension. 2010;55:531-538.
(2010)
Abstract
Gurley, SB; Mach, CL; Stegbauer, J; Yang, J; Snow, KP; Hu, A; Meyer, TW; Coffman, TM. Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. American Journal of Physiology: Renal Physiology. 2010;298:F788-F795.
(2010)
Abstract
Benigni, A; Corna, D; Zoja, C; Sonzogni, A; Latini, R; Salio, M; Conti, S; Rottoli, D; Longaretti, L; Cassis, P; Morigi, M; Coffman, TM; Remuzzi, G. Disruption of the Ang II type 1 receptor promotes longevity in mice. Journal of Clinical Investigation. 2009;119:524-530.
(2009)
Abstract
Crowley, SD; Vasievich, MP; Ruiz, P; Gould, SK; Parsons, KK; Pazmino, AK; Facemire, C; Chen, BJ; Kim, HS; Tran, TT; Pisetsky, DS; Barisoni, L; Prieto-Carrasquero, MC; Jeansson, M; Foster, MH; Coffman, TM. Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. Journal of Clinical Investigation. 2009;119:943-953.
(2009)
Abstract
Facemire, CS; Nixon, AB; Griffiths, R; Hurwitz, H; Coffman, TM. Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. Hypertension. 2009;54:652-658.
(2009)
Abstract
Coffman, TM; Crowley, SD. Kidney in hypertension: guyton redux. Hypertension. 2008;51:811-816.
(2008)
Abstract
Gurley, SB; Coffman, TM. The renin-angiotensin system and diabetic nephropathy. Seminars in Nephrology. 2007;27:144-152.
(2007)
Abstract
Coffman, TM. A WNK in the kidney controls blood pressure. Nature Genetics. 2006;38:1105-1106.
(2006)
Abstract
Crowley, SD; Gurley, SB; Herrera, MJ; Ruiz, P; Griffiths, R; Kumar, AP; Kim, HS; Smithies, O; Le, TH; Coffman, TM. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proceedings of the National Academy of Sciences of USA. 2006;103:17985-17990.
(2006)
Abstract
Gurley, SB; Allred, A; Le, TH; Griffiths, R; Mao, L; Philip, N; Haystead, TA; Donoghue, M; Breitbart, RE; Acton, SL; Rockman, HA; Coffman, TM. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. Journal of Clinical Investigation. 2006;116:2218-2225.
(2006)
Abstract
Crowley, SD; Gurley, SB; Oliverio, MI; Pazmino, AK; Griffiths, R; Flannery, PJ; Spurney, RF; Kim, HS; Smithies, O; Le, TH; Coffman, TM. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. Journal of Clinical Investigation. 2005;115:1092-1099.
(2005)
Abstract
Francois, H; Athirakul, K; Howell, D; Dash, R; Mao, L; Kim, HS; Rockman, HA; Fitzgerald, GA; Koller, BH; Coffman, TM. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metabolism. 2005;2:201-207.
(2005)
Abstract
Goulet, JL; Pace, AJ; Key, ML; Byrum, RS; Nguyen, M; Tilley, SL; Morham, SG; Langenbach, R; Stock, JL; McNeish, JD; Smithies, O; Coffman, TM; Koller, BH. E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. Journal of Immunology. 2004;173:1321-1326.
(2004)
Abstract
Rocha, PN; Plumb, TJ; Coffman, TM. Eicosanoids: lipid mediators of inflammation in transplantation. Springer Seminars in Immunopathology. 2003;25:215-227.
(2003)
Abstract
Tharaux, PL; Bukoski, RC; Rocha, PN; Crowley, SD; Ruiz, P; Nataraj, C; Howell, DN; Kaibuchi, K; Spurney, RF; Coffman, TM. Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. Journal of Immunology. 2003;171:96-105.
(2003)
Abstract
Thomas, DW; Rocha, PN; Nataraj, C; Robinson, LA; Spurney, RF; Koller, BH; Coffman, TM. Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. Journal of Immunology. 2003;171:6389-6395.
(2003)
Abstract
