Theodore N. Pappas, MD
Distinguished Professor of Surgical Innovation
Interim Chair, Department of Surgery
Chief, General and Advanced Gastrointestinal Surgery
Vice Dean for Medical Affairs
Department / Division
Surgery /
General and Advanced GI
Address
DUMC 3479
Durham, NC 27710
Appointment Telephone
919-684-4064
Office Telephone
919-681-3442
Fax Telephone
919-668-1826
- MD, Ohio State University College of Medicine, 1981
- Surgery, Brigham and Women's Hospital (Massachusetts), 1981-1988
Clinical Interests
Gastrointestinal surgery; advanced laparoscopic surgery; surgical complications of pancreatitis; benign and malignant esophageal, biliary, pancreatic and gastric disease; complicated abdominal-wall reconstructions
Research Interests
My laboratory is engaged in several areas of research all relating to gastrointestinal physiology:
1) We are currently studying upper gut motility as it relates to the cycloxygenace pathway. These studies are part of a drug development program in collaboration with GlaxoWellcome. The cycloxygenace pathway is important in the regulation of lower gastroesophageal sphincter function and gastric motility. Specifically COX-2 inhibitors appear to increase lower esophageal sphincter pressure and augment gastric emptying. This combination would be very effective in the treatment of gastroesophageal reflux and gastroparesis. Our current studies are evaluating the mechanism of action of COX-2 inhibitors on upper gut function.
2) In collaboration with Toku Takahashi (a PhD in my laboratory), we are studying colonic motility as it relates to short chain fatty acid (SCFA). SCFA appear to augment colonic motility and at intraluminal physiologic levels and cause mucosal damage at toxic levels. The mechanism of action of short chain fatty acids on colonic motility is being studied as well as the mechanism of toxic damage.
3) In collaboration with the Cook Catheter Company, we are currently studying the role of pig small intestine as a prosthetic agent in the treatment of gastrointestinal perforation. Commercially available pig small intestine tissue contains a variety of growth factors that appear to augment in-growth into this bio/prosthetic material. We are currently engaged in a collaborative effort with the Cook Catheter Company to explore the effectiveness of this bio/prosthetic device and the mechanism of tissue ingrowth in both the gastrointestinal tract and the abdominal wall.
This faculty member has no reported relationships with industry.
Representative Publications
Bailey, SH; Bull, DA; Harpole, DH; Rentz, JJ; Neumayer, LA; Pappas, TN; Daley, J; Henderson, WG; Krasnicka, B; Khuri, SF. Outcomes after esophagectomy: a ten-year prospective cohort. Annals of Thoracic Surgery. 2003;75:217-222.
(2003)
Abstract
Paulson, EK; Kalady, MF; Pappas, TN. Clinical practice. Suspected appendicitis. New England Journal of Medicine. 2003;348:236-242.
(2003)
Abstract
Takahashi, T; Matsuda, K; Kono, T; Pappas, TN. Inhibitory effects of hyperglycemia on neural activity of the vagus in rats. Intensive Care Medicine. 2003;29:309-311.
(2003)
Abstract
de la Fuente, SG; Gottfried, MR; Lawson, DC; Harris, MB; Mantyh, CR; Pappas, TN. Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. Journal of Gastrointestinal Surgery. 2003;7:96-101.
(2003)
Abstract
Bergin, D; Ho, LM; Jowell, PS; Pappas, TN; Paulson, EK. Simple pancreatic cysts: CT and endosonographic appearances. American Journal of Roentgenology. 2002;178:837-840.
(2002)
Abstract
Byrne, MF; Mitchell, RM; Stiffler, H; Jowell, PS; Branch, MS; Pappas, TN; Tyler, D; Baillie, J. Extensive investigation of patients with mild elevations of serum amylase and/or lipase is 'low yield'. Canadian Journal of Gastroenterology. 2002;16:849-854.
(2002)
Abstract
Ching, CD; Pappas, TN. A population-based cohort study comparing laparoscopic and open cholecystectomies: research in the new millennium. American Journal of Gastroenterology. 2002;97:226-228.
(2002)
Abstract
Gonzàlez-Stawinski, GV; Rovak, JM; Seigler, HF; Grant, JP; Kalady, MF; Biswas, S; Pappas, TN. Poor outcome and quality of life in female patients undergoing secondary surgery for recurrent peptic ulcer disease. Journal of Gastrointestinal Surgery. 2002;6:396-402.
(2002)
Abstract
Kalady, MF; Clary, BM; Clark, LA; Gottfried, M; Rohren, EM; Coleman, RE; Pappas, TN; Tyler, DS. Clinical utility of positron emission tomography in the diagnosis and management of periampullary neoplasms. Annals of Surgical Oncology. 2002;9:799-806.
(2002)
Abstract
Kalady, MF; Clary, BM; Tyler, DS; Pappas, TN. Pancreas-preserving duodenectomy in the management of duodenal familial adenomatous polyposis. Journal of Gastrointestinal Surgery. 2002;6:82-87.
(2002)
Abstract
Lagoo, S; McMahon, RL; Kakihara, M; Pappas, TN; Eubanks, S. The sixth decision regarding perforated duodenal ulcer. Journal of Society of Laparoendoscopic Surgeons. 2002;6:359-368.
(2002)
Abstract
Lagoo, SA; Pappas, TN. Laparoscopic repair for perforated peptic ulcer. Annals of Surgery. 2002;235:320-321.
(2002)
Abstract
Lau, CL; Palmer, SM; Howell, DN; McMahon, R; Hadjiliadis, D; Gaca, J; Pappas, TN; Davis, RD; Eubanks, S. Laparoscopic antireflux surgery in the lung transplant population. Surgical Endoscopy: surgical and interventional techniques. 2002;16:1674-1678.
(2002)
Abstract
McMahon, RL; Ali, A; Chekan, EG; Clary, EM; Garcia-Oria, MJ; Fina, MC; McRae, RL; Ko, A; Gandsas, A; Pappas, TN; Eubanks, WS. A canine model of gastroesophageal reflux disease (GERD). Surgical Endoscopy: surgical and interventional techniques. 2002;16:67-74.
(2002)
Abstract
de la Fuente, SG; McMahon, RL; Clary, EM; Harris, MB; Lawson, DC; Reynolds, JD; Eubanks, WS; Pappas, TN. Celecoxib (celebrex) increases canine lower esophageal sphincter pressure. Journal of Surgical Research. 2002;107:154-158.
(2002)
Abstract
Ching, CD; Pappas, TN. Endoscopic retrograde cholangiopancreatography and gallstone pancreatitis. Journal of Surgical Education. 2001;58:113-119.
(2001)
Abstract
Kalady, MF; Broome, AH; Meyers, WC; Pappas, TN. Immediate and long-term outcomes after lateral pancreaticojejunostomy for chronic pancreatitis. American Surgeon. 2001;67:478-483.
(2001)
Abstract
Onaitis, MW; Noone, RB; Fields, R; Hurwitz, H; Morse, M; Jowell, P; McGrath, K; Lee, C; Anscher, MS; Clary, B; Mantyh, C; Pappas, TN; Ludwig, K; Seigler, HF; Tyler, DS. Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival. Annals of Surgical Oncology. 2001;8:801-806.
(2001)
Abstract
Onaitis, MW; Noone, RB; Hartwig, M; Hurwitz, H; Morse, M; Jowell, P; McGrath, K; Lee, C; Anscher, MS; Clary, B; Mantyh, C; Pappas, TN; Ludwig, K; Seigler, HF; Tyler, DS. Neoadjuvant chemoradiation for rectal cancer: analysis of clinical outcomes from a 13-year institutional experience. Annals of Surgery. 2001;233:778-785.
(2001)
Abstract
White, RR; Hurwitz, HI; Morse, MA; Lee, C; Anscher, MS; Paulson, EK; Gottfried, MR; Baillie, J; Branch, MS; Jowell, PS; McGrath, KM; Clary, BM; Pappas, TN; Tyler, DS. Neoadjuvant chemoradiation for localized adenocarcinoma of the pancreas. Annals of Surgical Oncology. 2001;8:758-765.
(2001)
Abstract
White, RR; Paulson, EK; Freed, KS; Keogan, MT; Hurwitz, HI; Lee, C; Morse, MA; Gottfried, MR; Baillie, J; Branch, MS; Jowell, PS; McGrath, KM; Clary, BM; Pappas, TN; Tyler, DS. Staging of pancreatic cancer before and after neoadjuvant chemoradiation. Journal of Gastrointestinal Surgery. 2001;5:626-633.
(2001)
Abstract
Clary, BM; Tyler, DS; Dematos, P; Gottfried, M; Pappas, TN. Local ampullary resection with careful intraoperative frozen section evaluation for presumed benign ampullary neoplasms. Surgery. 2000;127:628-633.
(2000)
Abstract
Price, N; Gottfried, MR; Clary, E; Lawson, DC; Baillie, J; Mergener, K; Westcott, C; Eubanks, S; Pappas, TN. Safety and efficacy of India ink and indocyanine green as colonic tattooing agents. Gastrointestinal Endoscopy. 2000;51:438-442.
(2000)
Abstract
Selvan, RS; Pappas, TN; Ward, FE. Lack of evidence for MHC-unrestricted (atypical) recognition of mucin by mucinous pancreatic tumour-reactive T-cells. British Journal of Cancer. 2000;82:691-701.
(2000)
Abstract
Shichijo, K; Gottfried, M; Sekine, I; Pappas, TN. Dextran sulfate sodium-induced colitis in immunodeficient rats. Digestive Diseases and Sciences. 2000;45:2320-2326.
(2000)
Abstract
Brody, FJ; Chekan, EG; Pappas, TN; Eubanks, WS. Conversion factors for laparoscopic splenectomy for immune thrombocytopenic purpura. Surgical Endoscopy: surgical and interventional techniques. 1999;13:789-791.
(1999)
Abstract
Chekan, EG; Clark, L; Wu, J; Pappas, TN; Eubanks, S. Laparoscopic biliary and enteric bypass. Journal of Surgical Oncology. 1999;16:313-320.
(1999)
Abstract
Chekan, EG; Pappas, TN. The laparoscopic management of gastroesophageal reflux disease. Advances in Surgery. 1999;32:305-330.
(1999)
Abstract
Clark, LA; Pappas, TN. Long term outcome of endoscopic drainage of pancreatic pseudocysts. American Journal of Gastroenterology. 1999;94:8-9.
(1999)
Abstract
Miura, M; Lawson, DC; Clary, EM; Mangel, AW; Pappas, TN. Central modulation of rectal distension-induced blood pressure changes by alosetron, a 5-HT3 receptor antagonist. Digestive Diseases and Sciences. 1999;44:20-24.
(1999)
Abstract
Pappas, TN; Mangel, AW; Lawson, C. Review article: evaluation of drugs in experimental gut distension models. Alimentary Pharmacology and Therapeutics. 1999;13 Suppl 2:54-56.
(1999)
Abstract
Vitellas, KM; Paulson, EK; Enns, RA; Keogan, MT; Pappas, TN. Pancreatitis complicated by gland necrosis: evolution of findings on contrast-enhanced CT. Journal of Computer Assisted Tomography: a radiological journal dedicated to the basic and clinical aspects of reconstructive tomography. 1999;23:898-905.
(1999)
Abstract
Westcott, CJ; Pappas, TN. Laparoscopy and peripancreatic neoplasia. World Journal of Surgery. 1999;23:378-383.
(1999)
Abstract
Chen, AY; Daley, J; Pappas, TN; Henderson, WG; Khuri, SF. Growing use of laparoscopic cholecystectomy in the national Veterans Affairs Surgical Risk Study: effects on volume, patient selection, and selected outcomes. Annals of Surgery. 1998;227:12-24.
(1998)
Abstract
Freed, KS; Paulson, EK; Frederick, MG; Keogan, MT; Pappas, TN. Abdomen after a Puestow procedure: postoperative CT appearance, complications, and potential pitfalls. Radiology. 1997;203:790-794.
(1997)
Abstract
Geoghegan, J; Pappas, TN. Clinical uses of gut peptides. Annals of Surgery. 1997;225:145-154.
(1997)
Abstract
Geoghegan, JG; Cheng, CA; Lawson, C; Pappas, TN. The effect of caloric load and nutrient composition on induction of small intestinal satiety in dogs. Physiology and Behavior. 1997;62:39-42.
(1997)
Abstract
Geoghegan, JG; Pappas, TN. Central peptidergic control of gastric acid secretion. Gut. 1997;40:164-166.
(1997)
Abstract
Holzman, MD; Purut, CM; Reintgen, K; Eubanks, S; Pappas, TN. Laparoscopic ventral and incisional hernioplasty. Surgical Endoscopy: surgical and interventional techniques. 1997;11:32-35.
(1997)
Abstract
Holzman, MD; Reintgen, KL; Tyler, DS; Pappas, TN. The role of laparoscopy in the management of suspected pancreatic and periampullary malignancies. Journal of Gastrointestinal Surgery. 1997;1:236-243.
(1997)
Abstract
Kovacs, TO; Lloyd, KC; Lawson, DC; Pappas, TN; Walsh, JH. Inhibition of sham feeding-stimulated acid secretion in dogs by immunoneutralization of gastrin. American Journal of Physiology. 1997;273:G399-G403.
(1997)
Abstract
Lee, MC; Mannon, PJ; Grant, JP; Pappas, TN. Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain. Physiology and Behavior. 1997;62:1219-1223.
(1997)
Abstract
Mergener, K; Washington, MK; Pappas, TN; Sharara, AI. Benign gastric ulcer masquerading as a submucosal tumor. Endoscopy. 1997;29:331.
(1997)
Abstract
Baron, TH; Lee, JG; Schenkman, DI; Pappas, TN; Leung, JW. Suction sclerotherapy for the treatment of esophageal varices: a report of a preliminary feasibility study. Digestive Diseases: clinical reviews. 1996;14:356-361.
(1996)
Abstract
Branum, GD; Pappas, TN; Meyers, WC. The management of tumors of the ampulla of Vater by local resection. Annals of Surgery. 1996;224:621-627.
(1996)
Abstract
Broome, AH; Eisen, GM; Harland, RC; Collins, BH; Meyers, WC; Pappas, TN. Quality of life after treatment for pancreatitis. Annals of Surgery. 1996;223:665-670.
(1996)
Abstract
Mantyh, CR; Maggio, JE; Mantyh, PW; Vigna, SR; Pappas, TN. Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis. Digestive Diseases and Sciences. 1996;41:614-620.
(1996)
Abstract
Mantyh, CR; Pappas, TN; Lapp, JA; Washington, MK; Neville, LM; Ghilardi, JR; Rogers, SD; Mantyh, PW; Vigna, SR. Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology. 1996;111:1272-1280.
(1996)
Abstract
Marathe, US; Lilly, RE; Silvestry, SC; Schauer, PR; Davis, JW; Pappas, TN; Glower, DD. Alterations in hemodynamics and left ventricular contractility during carbon dioxide pneumoperitoneum. Surgical Endoscopy: surgical and interventional techniques. 1996;10:974-978.
(1996)
Abstract
Meyers, WC; Peterseim, DS; Pappas, TN; Schauer, PR; Eubanks, S; Murray, E; Suhocki, P. Low insertion of hepatic segmental duct VII-VIII is an important cause of major biliary injury or misdiagnosis. The American Journal of Surgery. 1996;171:187-191.
(1996)
Abstract
Okumura, T; Fukagawa, K; Tso, P; Taylor, IL; Pappas, TN. Apolipoprotein A-IV acts in the brain to inhibit gastric emptying in the rat. American Journal of Physiology. 1996;270:G49-G53.
(1996)
Abstract
Procop, GW; Harrell, LJ; Washington, MK; Owen, CH; Pappas, TN. Pericolic abscess due to Streptococcus pyogenes: report of a case that clinically mimicked acute cholecystitis. Clinical Infectious Diseases. 1996;23:182-183.
(1996)
Abstract
Schauer, PR; Meyers, WC; Eubanks, S; Norem, RF; Franklin, M; Pappas, TN. Mechanisms of gastric and esophageal perforations during laparoscopic Nissen fundoplication. Annals of Surgery. 1996;223:43-52.
(1996)
Abstract
Branum, GD; Pappas, TN; Meyers, WC. The use of pancreatic ductoscopy in the operative management of benign and malignant pancreatic disorders. Surgical Endoscopy: surgical and interventional techniques. 1995;9:53-55.
(1995)
Abstract
Mantyh, CR; Vigna, SR; Bollinger, RR; Mantyh, PW; Maggio, JE; Pappas, TN. Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Gastroenterology. 1995;109:850-860.
(1995)
Abstract
Okumura, T; Fukagawa, K; Tso, P; Taylor, IL; Pappas, TN. Mechanism of action of intracisternal apolipoprotein A-IV in inhibiting gastric acid secretion in rats. Gastroenterology. 1995;109:1583-1588.
(1995)
Abstract
Okumura, T; Grant, AP; Taylor, IL; Ohning, G; Taché, Y; Pappas, TN. Gastric mucosal damage induced by 2-deoxy-D-glucose involves medullary TRH in the rat. Regulatory Peptides. 1995;55:311-319.
(1995)
Abstract
Okumura, T; Pappas, TN; Taylor, IL. Pancreatic polypeptide microinjection into the dorsal motor nucleus inhibits pancreatic secretion in rats. Gastroenterology. 1995;108:1517-1525.
(1995)
Abstract
Okumura, T; Taylor, IL; Fukagawa, K; Tso, P; Pappas, TN. Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat. Brain Research. 1995;673:153-156.
(1995)
Abstract
Okumura, T; Taylor, IL; Ohning, G; Taché, Y; Pappas, TN. Intracisternal injection of TRH antibody blocks gastric emptying stimulated by 2-deoxy-D-glucose in rats. Brain Research. 1995;674:137-141.
(1995)
Abstract
Okumura, T; Taylor, IL; Pappas, TN. Microinjection of TRH analogue into the dorsal vagal complex stimulates pancreatic secretion in rats. American Journal of Physiology. 1995;269:G328-G334.
(1995)
Abstract
Peterseim, DS; Pappas, TN; Meyers, CH; Shaeffer, GS; Meyers, WC; Van Trigt, P. Management of biliary complications after heart transplantation. Journal of Heart and Lung Transplantation. 1995;14:623-631.
(1995)
Abstract
Tarnasky, PR; England, RE; Lail, LM; Pappas, TN; Cotton, PB. Cystic duct patency in malignant obstructive jaundice. An ERCP-based study relevant to the role of laparoscopic cholecystojejunostomy. Annals of Surgery. 1995;221:265-271.
(1995)
Abstract
Weltz, C; Pappas, TN. Pancreatography and the surgical management of pseudocysts. Gastrointestinal Endoscopy Clinics of North America. 1995;5:269-279.
(1995)
Abstract
Bittner, HB; Meyers, WC; Brazer, SR; Pappas, TN. Laparoscopic Nissen fundoplication: operative results and short-term follow-up. The American Journal of Surgery. 1994;167:193-198.
(1994)
Abstract
Bittner, HB; Pappas, TN. Laparoscopic approaches to symptomatic gastroesophageal reflux. Seminars in Gastrointestinal Disease. 1994;5:113-119.
(1994)
Abstract
DiMaio, JM; Clary, BM; Via, DF; Coveney, E; Pappas, TN; Lyerly, HK. Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. Surgery. 1994;116:205-213.
(1994)
Abstract
Geoghegan, JG; Lawson, DC; Cheng, CA; Pappas, TN. Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs. Brain Research. 1994;635:118-124.
(1994)
Abstract
Lawson, DC; Mantyh, CR; Pappas, TN. Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog. Digestive Diseases and Sciences. 1994;39:1405-1408.
(1994)
Abstract
Lee, MC; Lawson, DC; Pappas, TN. Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regulatory Peptides. 1994;52:227-234.
(1994)
Abstract
Lee, MC; Schiffman, SS; Pappas, TN. Role of neuropeptides in the regulation of feeding behavior: a review of cholecystokinin, bombesin, neuropeptide Y, and galanin. Neuroscience and Biobehavioral Reviews. 1994;18:313-323.
(1994)
Abstract
Lee, NL; Broome, A; Pappas, TN. Laparoscopic fundoplication: an alternate approach in the surgical treatment of esophageal reflux (continuing education credit). Today's OR nurse. 1994;16:7-11.
(1994)
Abstract
Mantyh, CR; Pappas, TN; Vigna, SR. Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. Gastroenterology. 1994;107:1019-1030.
(1994)
Abstract
Mantyh, CR; Vigna, SR; Maggio, JE; Mantyh, PW; Bollinger, RR; Pappas, TN. Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neuroscience Letters. 1994;178:255-259.
(1994)
Abstract
Okumura, T; Fukagawa, K; Tso, P; Taylor, IL; Pappas, TN. Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats. Gastroenterology. 1994;107:1861-1864.
(1994)
Abstract
Okumura, T; Pappas, TN; Taylor, IL. Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats. Neuroscience Letters. 1994;178:167-170.
(1994)
Abstract
Okumura, T; Pappas, TN; Taylor, IL. Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats. Digestive Diseases and Sciences. 1994;39:2398-2406.
(1994)
Abstract
Pappas, TN; Powers, M; Gottfried, MR; Cotton, PB. Balloon dilatation of the sphincter of Oddi facilitates passage of glass beads from the canine biliary tract. Journal of Laparoendoscopic Surgery. 1994;4:413-417.
(1994)
Abstract
Cheng, CA; Geoghegan, JG; Lawson, DC; Berlangieri, SU; Akwari, O; Pappas, TN. Central and peripheral effects of CCK receptor antagonists on satiety in dogs. American Journal of Physiology. 1993;265:G219-G223.
(1993)
Abstract
Geoghegan, JG; Lawson, DC; Cheng, CA; Opara, E; Taylor, IL; Pappas, TN. Intracerebroventricular neuropeptide Y increases gastric and pancreatic secretion in the dog. Gastroenterology. 1993;105:1069-1077.
(1993)
Abstract
Lawson, DC; Schiffman, SS; Pappas, TN. Short-term oral sensory deprivation: possible cause of binge eating in sham-feeding dogs. Physiology and Behavior. 1993;53:1231-1234.
(1993)
Abstract
Thomson, HJ; Geoghegan, JG; Farouk, M; Saperstein, LA; Chung, K; Meyers, WC; Pappas, TN. Exogenous neuropeptide Y blocks myoelectric activity in the upper gastrointestinal tract of starved dogs. Brain neuropeptide Y converts a fasting pattern of myoelectric activity to a fed pattern. Scandinavian Journal of Gastroenterology. 1993;28:469-474.
(1993)
Abstract
Warwick, ZS; Hall, WG; Pappas, TN; Schiffman, SS. Taste and smell sensations enhance the satiating effect of both a high-carbohydrate and a high-fat meal in humans. Physiology and Behavior. 1993;53:553-563.
(1993)
Abstract
Ahearne, PM; Baillie, JM; Cotton, PB; Baker, ME; Meyers, WC; Pappas, TN. An endoscopic retrograde cholangiopancreatography (ERCP)-based algorithm for the management of pancreatic pseudocysts. The American Journal of Surgery. 1992;163:111-115.
(1992)
Abstract
Davidoff, AM; Branum, GD; Murray, EA; Chong, WK; Ware, RE; Kinney, TR; Pappas, TN; Meyers, WC. The technique of laparoscopic cholecystectomy in children. Annals of Surgery. 1992;215:186-191.
(1992)
Abstract
Davidoff, AM; Pappas, TN; Murray, EA; Hilleren, DJ; Johnson, RD; Baker, ME; Newman, GE; Cotton, PB; Meyers, WC. Mechanisms of major biliary injury during laparoscopic cholecystectomy. Annals of Surgery. 1992;215:196-202.
(1992)
Abstract
Farouk, M; Geoghegan, JG; Pruthi, RS; Thomson, HJ; Pappas, TN; Meyers, WC. Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism. Gut. 1992;33:1562-1565.
(1992)
Abstract
Gulliver, DJ; Baker, ME; Cheng, CA; Meyers, WC; Pappas, TN. Malignant biliary obstruction: efficacy of thin-section dynamic CT in determining resectability. American Journal of Roentgenology. 1992;159:503-507.
(1992)
Abstract
Pappas, TN. Laparoscopic colectomy--the innovation continues. Annals of Surgery. 1992;216:701-702.
(1992)
Abstract
Pappas, TN. Physiological satiety implications of gastrointestinal antiobesity surgery. American Journal of Clinical Nutrition. 1992;55:571S-572S.
(1992)
Abstract
Ware, RE; Kinney, TR; Casey, JR; Pappas, TN; Meyers, WC. Laparoscopic cholecystectomy in young patients with sickle hemoglobinopathies. Journal of Pediatrics. 1992;120:58-61.
(1992)
Abstract
Brooks, DC; Pappas, TN. Intraoperative use of a 2-mm choledochoscope for the exploration of small bile ducts and the pancreatic duct. American Surgeon. 1991;57:216-218.
(1991)
Abstract
Cotton, PB; Baillie, J; Pappas, TN; Meyers, WS. Laparoscopic cholecystectomy and the biliary endoscopist. Gastrointestinal Endoscopy. 1991;37:94-97.
(1991)
Abstract
McDonnell, CH; Baker, ME; Cohan, RH; Nadel, SN; Leder, RA; Pappas, TN; Rice, RP. CT of fundoplication. Journal of Computer Assisted Tomography: a radiological journal dedicated to the basic and clinical aspects of reconstructive tomography. 1991;15:757-761.
(1991)
Abstract
Pappas, TN. Laparoscopic cholecystectomy: the standard of care for chronic and acute cholecystitis. Annals of Medicine. 1991;23:231.
(1991)
Abstract
Pappas, TN. Somatostatin and the treatment of cancer. Annals of Surgery. 1991;213:189.
(1991)
Abstract
Debas, HT; Goto, Y; Pappas, TN; Chey, WY. Geranyl-geranyl acetone: a novel stimulant of secretin release in the dog. Pancreas. 1990;5:555-558.
(1990)
Abstract
Pappas, TN; Slimane, TB; Brooks, DC. 100 consecutive common duct explorations without mortality. Annals of Surgery. 1990;211:260-262.
(1990)
Abstract
Powers, MA; Schiffman, SS; Lawson, DC; Pappas, TN; Taylor, IL. The effect of taste on gastric and pancreatic responses in dogs. Physiology and Behavior. 1990;47:1295-1297.
(1990)
Abstract
Quigley, RL; Pruitt, SK; Pappas, TN; Akwari, O. Primary hypertrophic pyloric stenosis in the adult. Archives of Surgery. 1990;125:1219-1221.
(1990)
Abstract
Mulvihill, SJ; Pappas, TN; Debas, HT. Characterization of in vivo acid secretory responses of rabbit with comparison to dog and rat. Digestive Diseases and Sciences. 1989;34:895-904.
(1989)
Abstract
Pappas, TN; Melendez, RL; Debas, HT. Gastric distension is a physiologic satiety signal in the dog. Digestive Diseases and Sciences. 1989;34:1489-1493.
(1989)
Abstract
Powers, MA; Pappas, TN. Physiologic approaches to the control of obesity. Annals of Surgery. 1989;209:255-260.
(1989)
Abstract
Mentzer, SJ; Osteen, RT; Pappas, TN; Rosenthal, DS; Canellos, GP; Wilson, RE. Surgical therapy of localized abdominal non-Hodgkin's lymphomas. Surgery. 1988;103:609-614.
(1988)
Abstract
Mulvihill, SJ; Pappas, TN; Fonkalsrud, EW; Debas, HT. The effect of somatostatin on experimental intestinal obstruction. Annals of Surgery. 1988;207:169-173.
(1988)
Abstract
Pappas, TN; Taylor, IL; Debas, HT. Postprandial neurohormonal control of gastric emptying. The American Journal of Surgery. 1988;155:98-103.
(1988)
Abstract
Pappas, TN; Mulvihill, SJ; Goto, Y; Debas, HT. Advances in drug therapy for peptic ulcer disease. Archives of Surgery. 1987;122:447-450.
(1987)
Abstract
Pappas, TN; Welton, M; Debas, HT; Rivier, J; Taché, Y. Corticotropin-releasing factor inhibits gastric emptying in dogs: studies on its mechanism of action. Peptides. 1987;8:1011-1014.
(1987)
Abstract
Mulvihill, S; Pappas, TN; Passaro, E; Debas, HT. The use of somatostatin and its analogs in the treatment of surgical disorders. Surgery. 1986;100:467-476.
(1986)
Abstract
Mulvihill, SJ; Pappas, TN; Debas, HT. Effect of increased intracranial pressure on gastric acid secretion. The American Journal of Surgery. 1986;151:110-116.
(1986)
Abstract
Pappas, TN; Debas, HT; Chang, AM; Taylor, IL. Peptide YY release by fatty acids is sufficient to inhibit gastric emptying in dogs. Gastroenterology. 1986;91:1386-1389.
(1986)
Abstract
Pappas, TN; Debas, HT; Taylor, IL. Enterogastrone-like effect of peptide YY is vagally mediated in the dog. Journal of Clinical Investigation. 1986;77:49-53.
(1986)
Abstract
Strah, KM; Melendez, RL; Pappas, TN; Debas, HT. Interactions of vasoactive intestinal polypeptide and cholecystokinin octapeptide on the control of gallbladder contraction. Surgery. 1986;99:469-473.
(1986)
Abstract
Strah, KM; Pappas, TN; Melendez, RL; Debas, HT. Contrasting cholinergic dependence of pancreatic and gallbladder responses to cholecystokinin. American Journal of Physiology. 1986;250:G665-G669.
(1986)
Abstract
Bunnett, NW; Clark, B; Debas, HT; Del Milton, RC; Kovacs, TO; Orloff, MS; Pappas, TN; Reeve, JR; Rivier, JE; Walsh, JH. Canine bombesin-like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog. The Journal of Physiology. 1985;365:121-130.
(1985)
Abstract
Pappas, TN; Debas, HT; Goto, Y; Taylor, IL. Peptide YY inhibits meal-stimulated pancreatic and gastric secretion. American Journal of Physiology. 1985;248:G118-G123.
(1985)
Abstract
Pappas, TN; Debas, HT; Taylor, IL. Peptide YY: metabolism and effect on pancreatic secretion in dogs. Gastroenterology. 1985;89:1387-1392.
(1985)
Abstract
Pappas, TN; Melendez, RL; Strah, KM; Debas, HT. Cholecystokinin is not a peripheral satiety signal in the dog. American Journal of Physiology. 1985;249:G733-G738.
(1985)
Abstract
Pappas, TN; Taché, Y; Debas, HT. Opposing central and peripheral actions of brain-gut peptides: a basis for regulation of gastric function. Surgery. 1985;98:183-190.
(1985)
Abstract
Lott, JA; Pappas, TN; Stang, JM; Pitts, C; Knopp, W. Electroconvulsive therapy does not change serum CK, LD, or LD isoenzymes. Journal of Clinical Psychiatry. 1982;43:169-170.
(1982)
Abstract
Pappas, TN; Lessler, MA; Ellison, EC; Carey, LC. Pancreatitis-associated ascitic fluid: effect on the oxygen consumption of liver cells. Experimental Biology and Medicine. 1982;169:438-444.
(1982)
Abstract
Yovos, JG; O'Dorisio, TM; Pappas, TN; Cataland, S; Thomas, FB; Mekhjian, H; Carey, LC. Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs. American Journal of Physiology. 1982;242:E53-E58.
(1982)
Abstract
Ellison, EC; Pappas, TN; Johnson, JA; Fabri, PJ; Carey, LC. Demonstration and characterization of the hemoconcentrating effect of ascitic fluid that accumulates during hemorrhagic pancreatitis. Journal of Surgical Research. 1981;30:241-248.
(1981)
Abstract
Pappas, TN; Gavino, VC; Ellison, EC; Cornwell, DG; Pace, WG; Carey, LC. Concentration of free fatty acids in pancreatitis-associated ascitic fluid. Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine. 1981;27:358.
(1981)
Abstract
Pappas, TN; Mironovich, RO. Barbiturate-induced coma to protect against cerebral ischemia and increased intracranial pressure. American Journal of Hospital Pharmacy. 1981;38:494-498.
(1981)
Abstract
Pappas, TN; Yovos, JG; Ellison, EC; O'Dorisio, TM; Cataland, S; Pace, WG; Carey, LC. Pancreatic polypeptide in acute pancreatitis and small-bowel infarction in dogs. Digestive Diseases and Sciences. 1981;26:1013-1018.
(1981)
Abstract
