Physicians

Department / Division
Radiology / Nuclear Medicine

Address
DUMC 3949
Durham, NC 27710

Appointment Telephone
919-684-7647

Office Telephone
919-684-7631

Fax Telephone
919-684-7167

Training

• MD, Dartmouth Medical School (New Hampshire), 1990

Residency

• Internal Medicine, Dartmouth-Hitchcock Medical Center (New Hampshire), 1990-1991
• Diagnostic Radiology, Deaconess Hospital (Massachusetts), 1992-1996

Fellowship

• Nuclear Radiology, Deaconess Hospital (Massachusetts), 1995-1996
• Cross-Sectional Imaging, Beth Israel Deaconess Medical Center (Massachusetts), 1996-1997
• Interventional/Intraoperative MRI, Brigham and Women's Hospital (Massachusetts), 1997-1998

Other Training

• PhD, Engineering Sciences, Dartmouth College (New Hampshire), 1990

Clinical Interests
Oncologic imaging, PET/CT, image processing, radiation therapy treatment planning, radionuclide therapy

Research Interests
1. Oncologic Imaging: PET/CT, novel PET radiotracers

2. Radionuclide therapy of cancer, Radiation Therapy Planning

3. Image-guided radiation therapy treatment planning

4. Hyperthermia

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Ma J, Zhang J, Zhou S, Hubbs JL, Foltz RJ, Hollis DR, Light KL, Wong TZ, Kelsey CR, Marks LB. Regional lung density changes after radiation therapy for tumors in and around thorax. Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):116-22. (2010) Abstract

Brady MJ, Thomas J, Wong TZ, Franklin KM, Ho LM, Paulson EK. Adrenal nodules at FDG PET/CT in patients known to have or suspected of having lung cancer: a proposal for an efficient diagnostic algorithm. Radiology. 2009 Feb;250(2):523-30. (2009) Abstract

Craciunescu OI, Blackwell KL, Jones EL, Macfall JR, Yu D, Vujaskovic Z, Wong TZ, Liotcheva V, Rosen EL, Prosnitz LR, Samulski TV, Dewhirst MW. DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study. Int J Hyperthermia. 2009;25(6):405-15. (2009) Abstract

Craciunescu OI, Stauffer PR, Soher BJ, Wyatt CR, Arabe O, Maccarini P, Das SK, Cheng KS, Wong TZ, Jones EL, Dewhirst MW, Vujaskovic Z, MacFall JR. Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. Med Phys. 2009 Nov;36(11):4848-58. (2009) Abstract

Kimura M, Tsivian M, Mouraviev V, Mayes JM, Price MM, Bannister MC, Madden JF, Wong TZ, Polascik TJ. Utilization of (111)In-Capromab pendetide SPECT-CT for detecting seminal vesicle invasion with recurrent prostate cancer after primary in situ therapy. Int J Urol. 2009 Dec;16(12):971-5. (2009) Abstract

Ma J, Zhang J, Zhou S, Hubbs JL, Foltz RJ, Hollis DR, Light KL, Wong TZ, Kelsey CR, Marks LB. Association between RT-induced changes in lung tissue density and global lung function. Int J Radiat Oncol Biol Phys. 2009 Jul 1;74(3):781-9. (2009) Abstract

Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009 Jun 20;27(18):3020-6. (2009) Abstract

Agress H Jr, Wong TZ, Shreve P. Interpretation and reporting of positron emission tomography-computed tomographic scans. Semin Ultrasound CT MR. 2008 Aug;29(4):283-90. (2008) Abstract

Bunyaviroch T, Turkington TG, Wong TZ, Wilson JW, Colsher JG, Coleman RE. Quantitative effects of contrast enhanced CT attenuation correction on PET SUV measurements. Mol Imaging Biol. 2008 Mar-Apr;10(2):107-13. (2008) Abstract

Ho LM, Paulson EK, Brady MJ, Wong TZ, Schindera ST. Lipid-poor adenomas on unenhanced CT: does histogram analysis increase sensitivity compared with a mean attenuation threshold? AJR Am J Roentgenol. 2008 Jul;191(1):234-8. (2008) Abstract

Koontz BF, Mouraviev V, Johnson JL, Mayes J, Chen SH, Wong TZ, Anscher MS, Sun L, Moul J, Polascik TJ. Use of local (111)in-capromab pendetide scan results to predict outcome after salvage radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):358-61. (2008) Abstract

Reardon DA, Zalutsky MR, Akabani G, Coleman RE, Friedman AH, Herndon JE 2nd, McLendon RE, Pegram CN, Quinn JA, Rich JN, Vredenburgh JJ, Desjardins A, Guruangan S, Boulton S, Raynor RH, Dowell JM, Wong TZ, Zhao XG, Friedman HS, Bigner DD. A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost. Neuro Oncol. 2008 Apr;10(2):182-9. (2008) Abstract

Sampson JH, Akabani G, Archer GE, Berger MS, Coleman RE, Friedman AH, Friedman HS, Greer K, Herndon JE 2nd, Kunwar S, McLendon RE, Paolino A, Petry NA, Provenzale JM, Reardon DA, Wong TZ, Zalutsky MR, Pastan I, Bigner DD. Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors. Neuro Oncol. 2008 Jun;10(3):320-9. (2008) Abstract

Wong TZ, Jain MK, Spratt SE. I-131, I-123, and F-18 FDG-PET imaging in a patient with diffuse sclerosing variant of papillary thyroid cancer. Clin Nucl Med. 2008 Dec;33(12):834-7. (2008) Abstract

Wong TZ, Lacy JL, Petry NA, Hawk TC, Sporn TA, Dewhirst MW, Vlahovic G. PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator. AJR Am J Roentgenol. 2008 Feb;190(2):427-32. (2008) Abstract

Zalutsky MR, Reardon DA, Akabani G, Coleman RE, Friedman AH, Friedman HS, McLendon RE, Wong TZ, Bigner DD. Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6. J Nucl Med. 2008 Jan;49(1):30-8. (2008) Abstract

Mao J, Zhang J, Zhou S, Das S, Hollis DR, Folz RJ, Wong TZ, Marks LB. Updated assessment of the six-minute walk test as predictor of acute radiation-induced pneumonitis. Int J Radiat Oncol Biol Phys. 2007 Mar 1;67(3):759-67. (2007) Abstract

Prosnitz RG, Hubbs JL, Evans ES, Zhou SM, Yu X, Blazing MA, Hollis DR, Tisch A, Wong TZ, Borges-Neto S, Hardenbergh PH, Marks LB. Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment. Cancer. 2007 Oct 15;110(8):1840-50. (2007) Abstract

Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol. 2007 May;4(5):316-21. (2007) Abstract

Wong TZ, Paulson EK, Nelson RC, Patz EF Jr, Coleman RE. Practical approach to diagnostic CT combined with PET. AJR Am J Roentgenol. 2007 Mar;188(3):622-9. (2007) Abstract

Yamamoto Y, Wong TZ, Turkington TG, Hawk TC, Coleman RE. Head and neck cancer: dedicated FDG PET/CT protocol for detection--phantom and initial clinical studies. Radiology. 2007 Jul;244(1):263-72. (2007) Abstract

Evans ES, Prosnitz RG, Yu X, Zhou SM, Hollis DR, Wong TZ, Light KL, Hardenbergh PH, Blazing MA, Marks LB. Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer. Int J Radiat Oncol Biol Phys. 2006 Nov 15;66(4):1125-34. (2006) Abstract

Kleiter MM, Yu D, Mohammadian LA, Niehaus N, Spasojevic I, Sanders L, Viglianti BL, Yarmolenko PS, Hauck M, Petry NA, Wong TZ, Dewhirst MW, Thrall DE. A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. Clin Cancer Res. 2006 Nov 15;12(22):6800-7. (2006) Abstract

Reardon DA, Akabani G, Coleman RE, Friedman AH, Friedman HS, Herndon JE 2nd, McLendon RE, Pegram CN, Provenzale JM, Quinn JA, Rich JN, Vredenburgh JJ, Desjardins A, Gururangan S, Guruangan S, Badruddoja M, Dowell JM, Wong TZ, Zhao XG, Zalutsky MR, Bigner DD. Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results. J Clin Oncol. 2006 Jan 1;24(1):115-22. (2006) Abstract

Reardon DA, Quinn JA, Akabani G, Coleman RE, Friedman AH, Friedman HS, Herndon JE 2nd, McLendon RE, Pegram CN, Provenzale JM, Dowell JM, Rich JN, Vredenburgh JJ, Desjardins A, Sampson JH, Gururangan S, Wong TZ, Badruddoja MA, Zhao XG, Bigner DD, Zalutsky MR. Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results. J Nucl Med. 2006 Jun;47(6):912-8. (2006) Abstract

Yamamoto Y, Wong TZ, Turkington TG, Hawk TC, Reardon DA, Coleman RE. 3'-Deoxy-3'-[F-18]fluorothymidine positron emission tomography in patients with recurrent glioblastoma multiforme: comparison with Gd-DTPA enhanced magnetic resonance imaging. Mol Imaging Biol. 2006 Nov-Dec;8(6):340-7. (2006) Abstract

Schwartz RB, Hsu L, Kacher DF, Wong TZ, Alexander E 3rd, Okon S, Guttmann CR, Black PM, Kelley RA, Moriarty T, Martin C, Isbister HG, Cahill CD, Spaulding SA, Jolesz FA. Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy. J Magn Reson Imaging 8(5): -1085-1089 (1998). (1998)

Wong TZ, Kettenbach J, Silverman SG, Schwartz RB, Morrison PR, Kacher DF, Jolesz FA. MR imaging guidance for minimally invasive procedures, in Surgical Applications of Energy, Thomas P. Ryan, Ed., Proceedings of SPIE, vol. 3249, pp. 162-170 (1998). (1998)

Wong TZ, Lateiner JS, Mahon TG, Zuo CS, Buff BL. Stereoscopically-guided characterization of 3-dimensional dynamic breast MR images. Radiology 198:288-291 (1996) (1996)

Roberts DW, Coughlin CT, Wong TZ, Fratkin JD, Douple EB, Strohbehn JW. Interstitial hyperthermia and iridium brachytherapy in the treatment of malignant glioma: a phase I clinical trial. J. Neurosurgery 64: 581-587 (1986). (1986)

Coughlin CT, Wong TZ, Strohbehn JW, Colacchio TA, Sutton JE, Belch RZ, Douple EB. Intra-operative interstitial microwave-induced hyperthermia and brachytherapy. Int. J. Radiation Oncol. Biol. Phys. 11:167-1678 (1985). (1985)