Department / Division:
Medicine / Gastroenterology

Address:
DUMC 3256

GSRB I
595 LaSalle Street, Suite 1073
Durham, NC 27710

Office Telephone:
919-684-4195

Fax Telephone:
919-684-4183

• MD, Flinders University of South Australia, 1999

• Internal Medicine, Duke University Medical Center, 2001-2004

• Gastroenterology, Duke University Medical Center, 2004-2007

Clinical Interests:
Acute and chronic liver diseases, general gastroenterology

Research Interests:
Hepatic stellate cell biology; Hepatic Fibrogenesis; Liver regeneration

Representative Publications:
Witek RP, Yang L, Liu R, Jung Y, Omenetti A, Syn WK, Choi SS, Cheong Y, Fearing CM, Agboola KM, Chen W, Diehl AM. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2009 Jan;136(1):320-330.e2. (2009) Abstract

Syn WK, Yang L, Chiang D, Qian Y, Jung Y, Karaca G, Choi SS, Witek RP, Omenetti A, Pereira TA, Diehl AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver Int. 2009 Apr 16. (2009) Abstract

Syn WK, Witek RP, Curbishley SM, Jung Y, Choi SS, Enrich B, Omenetti A, Agboola KM, Fearing CM, Tilg H, Adams DH, Diehl AM. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. Eur J Immunol. 2009 Jul;39(7):1879-92. (2009) Abstract

Syn WK, Teaberry V, Choi SS, Diehl AM. Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. Semin Liver Dis. 2009 May;29(2):200-10. (2009) Abstract

Syn WK, Omenetti A, Abdelmalek M, Guy CD, Yang L, Wang J, Witek RP, Fearing CM, Pereira TA, Teaberry V, Choi SS, Vancells JC, Karaca G, Diehl AM. Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Non-Alcoholic Fatty Liver Disease. Gastroenterology. 2009 Jul 2. (2009) Abstract

Omenetti A, Syn WK, Jung Y, Francis H, Porrello A, Witek RP, Choi SS, Yang L, Mayo MJ, Gershwin ME, Alpini G, Diehl AM. Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. Hepatology. 2009 Aug;50(2):518-27. (2009) Abstract

Yang L, Jung Y, Omenetti A, Witek RP, Choi S, Vandongen HM, Huang J, Alpini GD, Diehl AM. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells. 2008 Aug;26(8):2104-13. (2008) Abstract

Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM. The Hedgehog Pathway Regulates Remodeling Responses to Biliary Obstruction in Rats. Gut. 2008 Mar 28. (2008) Abstract

Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic Fatty liver disease.  Semin Liver Dis.  2008 Nov;28(4):370-9. (2008) Abstract

Choi SS, Diehl AM. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol. 2008 Jun;19(3):295-300. (2008) Abstract

Omenetti A, Yang L, Li YX, McCall SJ, Jung Y, Sicklick JK, Huang J, Choi S, Suzuki A, Diehl AM. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest. 2007 May;87(5):499-514. (2007) Abstract

Fleig SV, Choi SS, Yang L, Jung Y, Omenetti A, VanDongen HM, Huang J, Sicklick JK, Diehl AM. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Lab Invest. 2007 Dec;87(12):1227-39. (2007) Abstract

Suzuki A, McCall S, Choi SS, Sicklick JK, Huang J, Qi Y, Zdanowicz M, Camp T, Li YX, Diehl AM. Interleukin-15 increases hepatic regenerative activity. J Hepatol. 2006 Sep;45(3):410-8. (2006) Abstract

Sicklick JK, Choi SS, Bustamante M, McCall SJ, Pérez EH, Huang J, Li YX, Rojkind M, Diehl AM. Evidence for epithelial-mesenchymal transitions in adult liver cells. Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G575-83. (2006) Abstract

Choi SS, Sicklick JK, Ma Q, Yang L, Huang J, Qi Y, Chen W, Li YX, Goldschmidt-Clermont PJ, Diehl AM. Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology. 2006 Nov;44(5):1267-77. (2006) Abstract

Sicklick JK, Li YX, Choi SS, Qi Y, Chen W, Bustamante M, Huang J, Zdanowicz M, Camp T, Torbenson MS, Rojkind M, Diehl AM. Role for hedgehog signaling in hepatic stellate cell activation and viability. Lab Invest. 2005 Nov;85(11):1368-80. (2005) Abstract

Choi S, Diehl AM. Role of inflammation in nonalcoholic steatohepatitis. Curr Opin Gastroenterol. 2005 Nov;21(6):702-7. (2005) Abstract

Tucker PC, Griffin DE, Choi S, Bui N, Wesselingh S. Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. J Virol. 1996 Jun;70(6):3972-7. (1996) Abstract

Mokhtarian F, Wesselingh SL, Choi S, Maeda A, Griffin DE, Sobel RA, Grob D. Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis. J Neuroimmunol. 1996 May;66(1-2):11-22. (1996) Abstract

Hsieh ST, Choi S, Lin WM, Chang YC, Mcarthur JC, Griffin JW. Epidermal denervation and its effects on keratinocytes and Langerhans cells. J Neurocytol. 1996 Sep;25(9):513-24. (1996) Abstract

Rho MB, Wesselingh S, Glass JD, McArthur JC, Choi S, Griffin J, Tyor WR. A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia. Brain Behav Immun. 1995 Dec;9(4):366-77. (1995) Abstract

Herskowitz A, Choi S, Ansari AA, Wesselingh S. Cytokine mRNA expression in postischemic/reperfused myocardium. Am J Pathol. 1995 Feb;146(2):419-28. (1995) Abstract

Wesselingh SL, Levine B, Fox RJ, Choi S, Griffin DE. Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.  J Immunol.  1994 Feb 1;152(3):1289-97. (1994) Abstract

Bö L, Dawson TM, Wesselingh S, Mörk S, Choi S, Kong PA, Hanley D, Trapp BD. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol. 1994 Nov;36(5):778-86. (1994) Abstract