Physicians

Department / Division
Medicine / Medicine - Gastroenterology

Address
DUMC 3256
Durham, NC 27710

595 LaSalle Street
Suite 1073
Durham, NC 27705

Appointment Telephone
919-286-0411, extension 6945

Office Telephone
919-684-4195

Fax Telephone
919-684-4183

Training

• MD, Flinders University School of Medicine (Australia), 1999

Residency

• Internal Medicine, Duke University Medical Center, 2001-2004

Fellowship

• Gastroenterology, Duke University Medical Center, 2004-2007

Clinical Interests
Acute and chronic liver diseases, general gastroenterology

Research Interests
Hepatic stellate cell biology; Hepatic Fibrogenesis; Liver regeneration

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Choi, SS; Bradrick, S; Qiang, G; Mostafavi, A; Chaturvedi, G; Weinman, SA; Diehl, AM; Jhaveri, R. Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication. Hepatology. 2011;54:1580-1590. (2011) Abstract

Choi, SS; Omenetti, A; Syn, WK; Diehl, AM. The role of Hedgehog signaling in fibrogenic liver repair. The International Journal of Biochemistry and Cell Biology. 2011;43:238-244. (2011) Abstract

Omenetti, A; Bass, LM; Anders, RA; Clemente, MG; Francis, H; Guy, CD; McCall, S; Choi, SS; Alpini, G; Schwarz, KB; Diehl, AM; Whitington, PF. Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia. Hepatology. 2011;53:1246-1258. (2011) Abstract

Omenetti, A; Choi, S; Michelotti, G; Diehl, AM. Hedgehog signaling in the liver. Journal of Hepatology. 2011;54:366-373. (2011) Abstract

Omenetti, A; Yang, L; Gainetdinov, RR; Guy, CD; Choi, SS; Chen, W; Caron, MG; Diehl, AM. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2011;300:G303-G315. (2011) Abstract

Philips, GM; Chan, IS; Swiderska, M; Schroder, VT; Guy, C; Karaca, GF; Moylan, C; Venkatraman, T; Feuerlein, S; Syn, WK; Jung, Y; Witek, RP; Choi, S; Michelotti, GA; Rangwala, F; Merkle, E; Lascola, C; Diehl, AM. Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. PLoS One. 2011;6:e23943. (2011) Abstract

Syn, WK; Choi, SS; Liaskou, E; Karaca, GF; Agboola, KM; Oo, YH; Mi, Z; Pereira, TA; Zdanowicz, M; Malladi, P; Chen, Y; Moylan, C; Jung, Y; Bhattacharya, SD; Teaberry, V; Omenetti, A; Abdelmalek, MF; Guy, CD; Adams, DH; Kuo, PC; Michelotti, GA; Whitington, PF; Diehl, AM. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology. 2011;53:106-115. (2011) Abstract

Choi, SS; Syn, WK; Karaca, GF; Omenetti, A; Moylan, CA; Witek, RP; Agboola, KM; Jung, Y; Michelotti, GA; Diehl, AM. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. Journal of Biological Chemistry. 2010;285:36551-36560. (2010) Abstract

Choi, SS; Witek, RP; Yang, L; Omenetti, A; Syn, WK; Moylan, CA; Jung, Y; Karaca, GF; Teaberry, VS; Pereira, TA; Wang, J; Ren, XR; Diehl, AM. Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells. Hepatology. 2010;52:278-290. (2010) Abstract

Jung, Y; Witek, RP; Syn, WK; Choi, SS; Omenetti, A; Premont, R; Guy, CD; Diehl, AM. Signals from dying hepatocytes trigger growth of liver progenitors. Gut. 2010;59:655-665. (2010) Abstract

McGoogan, KE; Smith, PB; Choi, SS; Berman, W; Jhaveri, R. Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis. Journal of Pediatric Gastroenterology and Nutrition. 2010;50:344-346. (2010) Abstract

Ochoa, B; Syn, WK; Delgado, I; Karaca, GF; Jung, Y; Wang, J; Zubiaga, AM; Fresnedo, O; Omenetti, A; Zdanowicz, M; Choi, SS; Diehl, AM. Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. Hepatology. 2010;51:1712-1723. (2010) Abstract

Pereira, TDEA; Witek, RP; Syn, WK; Choi, SS; Bradrick, S; Karaca, GF; Agboola, KM; Jung, Y; Omenetti, A; Moylan, CA; Yang, L; Fernandez-Zapico, ME; Jhaveri, R; Shah, VH; Pereira, FE; Diehl, AM. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Laboratory Investigation. 2010;90:1690-1703. (2010) Abstract

Syn, WK; Oo, YH; Pereira, TA; Karaca, GF; Jung, Y; Omenetti, A; Witek, RP; Choi, SS; Guy, CD; Fearing, CM; Teaberry, V; Pereira, FE; Adams, DH; Diehl, AM. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology. 2010;51:1998-2007. (2010) Abstract

Choi, SS; Diehl, AM. Epithelial-to-mesenchymal transitions in the liver. Hepatology. 2009;50:2007-2013. (2009) Abstract

Choi, SS; Omenetti, A; Witek, RP; Moylan, CA; Syn, WK; Jung, Y; Yang, L; Sudan, DL; Sicklick, JK; Michelotti, GA; Rojkind, M; Diehl, AM. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2009;297:G1093-G1106. (2009) Abstract

Miller, MW; Basra, S; Kulp, DW; Billings, PC; Choi, S; Beavers, MP; McCarty, OJ; Zou, Z; Kahn, ML; Bennett, JS; DeGrado, WF. Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proceedings of the National Academy of Sciences of USA. 2009;106:719-724. (2009) Abstract

Omenetti, A; Syn, WK; Jung, Y; Francis, H; Porrello, A; Witek, RP; Choi, SS; Yang, L; Mayo, MJ; Gershwin, ME; Alpini, G; Diehl, AM. Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. Hepatology. 2009;50:518-527. (2009) Abstract

Syn, WK; Choi, SS; Diehl, AM. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clinics in Liver Disease. 2009;13:565-580. (2009) Abstract

Syn, WK; Jung, Y; Omenetti, A; Abdelmalek, M; Guy, CD; Yang, L; Wang, J; Witek, RP; Fearing, CM; Pereira, TA; Teaberry, V; Choi, SS; Conde-Vancells, J; Karaca, GF; Diehl, AM. Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology. 2009;137:1478-1488.e8. (2009) Abstract

Syn, WK; Teaberry, V; Choi, SS; Diehl, AM. Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. Seminars in Liver Disease. 2009;29:200-210. (2009) Abstract

Syn, WK; Witek, RP; Curbishley, SM; Jung, Y; Choi, SS; Enrich, B; Omenetti, A; Agboola, KM; Fearing, CM; Tilg, H; Adams, DH; Diehl, AM. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. European Journal of Immunology. 2009;39:1879-1892. (2009) Abstract

Syn, WK; Yang, L; Chiang, DJ; Qian, Y; Jung, Y; Karaca, G; Choi, SS; Witek, RP; Omenetti, A; Pereira, TA; Diehl, AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver International. 2009;29:1262-1272. (2009) Abstract

Witek, RP; Stone, WC; Karaca, FG; Syn, WK; Pereira, TA; Agboola, KM; Omenetti, A; Jung, Y; Teaberry, V; Choi, SS; Guy, CD; Pollard, J; Charlton, P; Diehl, AM. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology. 2009;50:1421-1430. (2009) Abstract

Witek, RP; Yang, L; Liu, R; Jung, Y; Omenetti, A; Syn, WK; Choi, SS; Cheong, Y; Fearing, CM; Agboola, KM; Chen, W; Diehl, AM. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2009;136:320-330.e2. (2009) Abstract

Choi, SS; Diehl, AM. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Current Opinion in Lipidology. 2008;19:295-300. (2008) Abstract

Jou, J; Choi, SS; Diehl, AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Seminars in Liver Disease. 2008;28:370-379. (2008) Abstract

Omenetti, A; Popov, Y; Jung, Y; Choi, SS; Witek, RP; Yang, L; Brown, KD; Schuppan, D; Diehl, AM. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut. 2008;57:1275-1282. (2008) Abstract

Omenetti, A; Porrello, A; Jung, Y; Yang, L; Popov, Y; Choi, SS; Witek, RP; Alpini, G; Venter, J; Vandongen, HM; Syn, WK; Baroni, GS; Benedetti, A; Schuppan, D; Diehl, AM. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. Journal of Clinical Investigation. 2008;118:3331-3342. (2008) Abstract

Yang, L; Jung, Y; Omenetti, A; Witek, RP; Choi, S; Vandongen, HM; Huang, J; Alpini, GD; Diehl, AM. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells. 2008;26:2104-2113. (2008) Abstract

Fleig, SV; Choi, SS; Yang, L; Jung, Y; Omenetti, A; VanDongen, HM; Huang, J; Sicklick, JK; Diehl, AM. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Laboratory Investigation. 2007;87:1227-1239. (2007) Abstract

Omenetti, A; Yang, L; Li, YX; McCall, SJ; Jung, Y; Sicklick, JK; Huang, J; Choi, S; Suzuki, A; Diehl, AM. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Laboratory Investigation. 2007;87:499-514. (2007) Abstract

Choi, SS; Sicklick, JK; Ma, Q; Yang, L; Huang, J; Qi, Y; Chen, W; Li, YX; Goldschmidt-Clermont, PJ; Diehl, AM. Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology. 2006;44:1267-1277. (2006) Abstract

Sicklick, JK; Choi, SS; Bustamante, M; McCall, SJ; Pérez, EH; Huang, J; Li, YX; Rojkind, M; Diehl, AM. Evidence for epithelial-mesenchymal transitions in adult liver cells. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2006;291:G575-G583. (2006) Abstract

Suzuki, A; McCall, S; Choi, SS; Sicklick, JK; Huang, J; Qi, Y; Zdanowicz, M; Camp, T; Li, YX; Diehl, AM. Interleukin-15 increases hepatic regenerative activity. Journal of Hepatology. 2006;45:410-418. (2006) Abstract

Choi, S; Diehl, AM. Role of inflammation in nonalcoholic steatohepatitis. Current Opinion in Gastroenterology. 2005;21:702-707. (2005) Abstract

Sicklick, JK; Li, YX; Choi, SS; Qi, Y; Chen, W; Bustamante, M; Huang, J; Zdanowicz, M; Camp, T; Torbenson, MS; Rojkind, M; Diehl, AM. Role for hedgehog signaling in hepatic stellate cell activation and viability. Laboratory Investigation. 2005;85:1368-1380. (2005) Abstract

Hsieh, ST; Choi, S; Lin, WM; Chang, YC; Mcarthur, JC; Griffin, JW. Epidermal denervation and its effects on keratinocytes and Langerhans cells. Brain Cell Biology. 1996;25:513-524. (1996) Abstract

Mokhtarian, F; Wesselingh, SL; Choi, S; Maeda, A; Griffin, DE; Sobel, RA; Grob, D. Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis. Journal of Neuroimmunology. 1996;66:11-22. (1996) Abstract

Tucker, PC; Griffin, DE; Choi, S; Bui, N; Wesselingh, S. Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. Journal of Virology. 1996;70:3972-3977. (1996) Abstract

Herskowitz, A; Choi, S; Ansari, AA; Wesselingh, S. Cytokine mRNA expression in postischemic/reperfused myocardium. American Journal of Pathology. 1995;146:419-428. (1995) Abstract

Rho, MB; Wesselingh, S; Glass, JD; McArthur, JC; Choi, S; Griffin, J; Tyor, WR. A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia. Brain, Behavior, and Immunity. 1995;9:366-377. (1995) Abstract

Bö, L; Dawson, TM; Wesselingh, S; Mörk, S; Choi, S; Kong, PA; Hanley, D; Trapp, BD. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Annals of Neurology. 1994;36:778-786. (1994) Abstract

Wesselingh, SL; Levine, B; Fox, RJ; Choi, S; Griffin, DE. Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response. Journal of Immunology. 1994;152:1289-1297. (1994) Abstract