Physicians

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC 102347
Durham, NC 27710

Appointment Telephone
919-684-2240

Office Telephone
919-684-0245

Fax Telephone
919-681-9571

Training

• MD, Duke University School of Medicine, 1993

Residency

• Internal Medicine, Duke University Medical Center, 1993-1996
• Pulmonary and Critical Care Medicine, Duke University Medical Center, 1996-1999

Other Training

• MHS, Duke University School of Medicine, 1998-2000

Clinical Interests
Pulmonary and transplant medicine, biostatisics and clinical trials, transplant immunology

Research Interests
Dr. Palmer leads a successful program of clinical, basic and translational research. He currently directs the pulmonary research program at the Duke Clinical Research Institute and oversees a laboratory of approximately 10 individuals engaged in translational and basic research. His previous accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of the only prospective multicenter study of CMV prevention in lung transplantation. He is also Associate Director of the Clinical Research Training Program at Duke and the Scientific Director for the Lung Transplant Program. Dr. Palmer has over 100 peer reviewed publications, received numerous awards, chaired many sessions at national and international meetings and is on the editorial board of many prominent journals.
Current basic projects in the lab are studying the role of innate immunity in pulmonary GVHD and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• American Soceity for Clinical Investigation
• American Society of Transplantation
• Robert Micheal Educational Institute
• UpToDate, Inc.

Representative Publications
Davis, WA; Finlen Copeland, CA; Todd, JL; Snyder, LD; Martissa, JA; Palmer, SM. Spirometrically significant acute rejection increases the risk for BOS and death after lung transplantation. American Journal of Transplantation. 2012;12:745-752. (2012) Abstract

Goetzinger, AM; Blumenthal, JA; O'Hayer, CV; Babyak, MA; Hoffman, BM; Ong, L; Davis, RD; Smith, SR; Rogers, JG; Milano, CA; Smith, AD; Kuo, PC; Palmer, SM. Stress and coping in caregivers of patients awaiting solid organ transplantation. Clinical Transplantation. 2012;26:97-104. (2012) Abstract

Gowdy, KM; Nugent, JL; Martinu, T; Potts, E; Snyder, LD; Foster, WM; Palmer, SM. Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2012;46:249-256. (2012) Abstract

Jiang, D; Liang, J; Guo, R; Xie, T; Kelly, FL; Martinu, T; Yang, T; Lovgren, AK; Chia, J; Liu, N; Jung, Y; Palmer, SM; Noble, PW. Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation. American Journal of Respiratory Cell and Molecular Biology. 2012;46:592-598. (2012) Abstract

Morgan, DL; Jokinen, MP; Price, HC; Gwinn, WM; Palmer, SM; Flake, GP. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. Toxicologic Pathology. 2012;40:448-465. (2012) Abstract

Patel, N; Snyder, LD; Finlen-Copeland, A; Palmer, SM. Is prevention the best treatment? CMV after lung transplantation. American Journal of Transplantation. 2012;12:539-544. (2012) Abstract

Diamond, JM; Kawut, SM; Lederer, DJ; Ahya, VN; Kohl, B; Sonett, J; Palmer, SM; Crespo, M; Wille, K; Lama, VN; Shah, PD; Orens, J; Bhorade, S; Weinacker, A; Demissie, E; Bellamy, S; Christie, JD; Ware, LB; Lung Transplant Outcomes Group. Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction. American Journal of Transplantation. 2011;11:561-567. (2011) Abstract

Diamond, JM; Lederer, DJ; Kawut, SM; Lee, J; Ahya, VN; Bellamy, S; Palmer, SM; Lama, VN; Bhorade, S; Crespo, M; Demissie, E; Sonett, J; Wille, K; Orens, J; Shah, PD; Weinacker, A; Weill, D; Kohl, BA; Deutschman, CC; Arcasoy, S; Shah, AS; Belperio, JA; Wilkes, D; Reynolds, JM; Ware, LB; Christie, JD; Lung Transplant Outcomes Group. Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis. American Journal of Transplantation. 2011;11:2517-2522. (2011) Abstract

Finlen Copeland, CA; Davis, WA; Snyder, LD; Banks, M; Avery, R; Davis, RD; Palmer, SM. Long-term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: a single-center, long-term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial. Journal of Heart and Lung Transplantation. 2011;30:990-996. (2011) Abstract

Kreisel, D; Gelman, AE; Palmer, SM. In pursuit of new experimental models of obliterative bronchiolitis. American Journal of Transplantation. 2011;11:882-883. (2011) Abstract

Lederer, DJ; Kawut, SM; Wickersham, N; Winterbottom, C; Bhorade, S; Palmer, SM; Lee, J; Diamond, JM; Wille, KM; Weinacker, A; Lama, VN; Crespo, M; Orens, JB; Sonett, JR; Arcasoy, SM; Ware, LB; Christie, JD; Lung Transplant Outcomes Group. Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study. American Journal of Respiratory and Critical Care Medicine. 2011;184:1055-1061. (2011) Abstract

Martinu, T; Kinnier, CV; Gowdy, KM; Kelly, FL; Snyder, LD; Jiang, D; Foster, WM; Garantziotis, S; Belperio, JA; Noble, PW; Palmer, SM. Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3. Journal of Heart and Lung Transplantation. 2011;30:717-725. (2011) Abstract

Martinu, T; Palmer, SM; Ortiz, LA. Lung-resident mesenchymal stromal cells. A new player in post-transplant bronchiolitis obliterans syndrome?. American Journal of Respiratory and Critical Care Medicine. 2011;183:968-970. (2011) Abstract

Martinu, T; Pavlisko, EN; Chen, DF; Palmer, SM. Acute allograft rejection: cellular and humoral processes. Clinics in Chest Medicine. 2011;32:295-310. (2011) Abstract

Palmer, SM; Flake, GP; Kelly, FL; Zhang, HL; Nugent, JL; Kirby, PJ; Foley, JF; Gwinn, WM; Morgan, DL. Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. PLoS One. 2011;6:e17644. (2011) Abstract

Sims, MW; Beers, MF; Ahya, VN; Kawut, SM; Sims, KD; Lederer, DJ; Palmer, SM; Wille, K; Lama, VN; Shah, PD; Orens, JB; Bhorade, S; Crespo, M; Weinacker, A; Demissie, E; Bellamy, S; Christie, JD; Ware, LB; Lung Transplant Outcomes Group. Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis. Chest. 2011;140:489-496. (2011) Abstract

Snyder, LD; Medinas, R; Chan, C; Sparks, S; Davis, WA; Palmer, SM; Weinhold, KJ. Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis. American Journal of Transplantation. 2011;11:553-560. (2011) Abstract

Todd, JL; Goldstein, DB; Ge, D; Christie, J; Palmer, SM. The state of genome-wide association studies in pulmonary disease: a new perspective. American Journal of Respiratory and Critical Care Medicine. 2011;184:873-880. (2011) Abstract

Todd, JL; Palmer, SM. Bronchiolitis obliterans syndrome: the final frontier for lung transplantation. Chest. 2011;140:502-508. (2011) Abstract

Castor, JM; Wood, RK; Muir, AJ; Palmer, SM; Shimpi, RA. Gastroesophageal reflux and altered motility in lung transplant rejection. Neurogastroenterology and Motility. 2010;22:841-850. (2010) Abstract

Finlen Copeland, CA; Snyder, LD; Zaas, DW; Turbyfill, WJ; Davis, WA; Palmer, SM. Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients. American Journal of Respiratory and Critical Care Medicine. 2010;182:784-789. (2010) Abstract

Martinu, T; Howell, DN; Palmer, SM. Acute cellular rejection and humoral sensitization in lung transplant recipients. Seminars in Respiratory and Critical Care Medicine: pulmonology, critical care, allergy and immunology, infections. 2010;31:179-188. (2010) Abstract

Palmer, SM; Limaye, AP; Banks, M; Gallup, D; Chapman, J; Lawrence, EC; Dunitz, J; Milstone, A; Reynolds, J; Yung, GL; Chan, KM; Aris, R; Garrity, E; Valentine, V; McCall, J; Chow, SC; Davis, RD; Avery, R. Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial. Annals of Internal Medicine. 2010;152:761-769. (2010) Abstract

Snyder, LD; Finlen-Copeland, CA; Turbyfill, WJ; Howell, D; Willner, DA; Palmer, SM. Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation. American Journal of Respiratory and Critical Care Medicine. 2010;181:1391-1396. (2010) Abstract

Todd, JL; Palmer, SM. Lung transplantation in advanced COPD: is it worth it?. Seminars in Respiratory and Critical Care Medicine: pulmonology, critical care, allergy and immunology, infections. 2010;31:365-372. (2010) Abstract

Martinu, T; Chen, DF; Palmer, SM. Acute rejection and humoral sensitization in lung transplant recipients. Proceedings of the American Thoracic Society. 2009;6:54-65. (2009) Abstract

Wahidi, MM; Willner, DA; Snyder, LD; Hardison, JL; Chia, JY; Palmer, SM. Diagnosis and outcome of early pleural space infection following lung transplantation. Chest. 2009;135:484-491. (2009) Abstract

Kinnier, CV; Eu, JP; Davis, RD; Howell, DN; Sheets, J; Palmer, SM. Successful bilateral lung transplantation for lymphangiomatosis. American Journal of Transplantation. 2008;8:1946-1950. (2008) Abstract

Martinu, T; Babyak, MA; O'Connell, CF; Carney, RM; Trulock, EP; Davis, RD; Blumenthal, JA; Palmer, SM; INSPIRE Investigators. Baseline 6-min walk distance predicts survival in lung transplant candidates. American Journal of Transplantation. 2008;8:1498-1505. (2008) Abstract

Morgan, DL; Flake, GP; Kirby, PJ; Palmer, SM. Respiratory toxicity of diacetyl in C57BL/6 mice. Toxicological Sciences. 2008;103:169-180. (2008) Abstract

Palmer, SM; Klimecki, W; Yu, L; Reinsmoen, NL; Snyder, LD; Ganous, TM; Burch, L; Schwartz, DA. Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14. American Journal of Transplantation. 2007;7:693-699. (2007) Abstract

Reams, BD; Musselwhite, LW; Zaas, DW; Steele, MP; Garantziotis, S; Eu, PC; Snyder, LD; Curl, J; Lin, SS; Davis, RD; Palmer, SM. Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation. American Journal of Transplantation. 2007;7:2802-2808. (2007) Abstract

Reddy, AJ; Zaas, AK; Hanson, KE; Palmer, SM. A single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome. Journal of Heart and Lung Transplantation. 2007;26:1286-1292. (2007) Abstract

Barbour, KA; Blumenthal, JA; Palmer, SM. Psychosocial issues in the assessment and management of patients undergoing lung transplantation. Chest. 2006;129:1367-1374. (2006) Abstract

Blumenthal, JA; Babyak, MA; Keefe, FJ; Davis, RD; Lacaille, RA; Carney, RM; Freedland, KE; Trulock, E; Palmer, SM. Telephone-based coping skills training for patients awaiting lung transplantation. Journal of Consulting and Clinical Psychology. 2006;74:535-544. (2006) Abstract

Dickson, RP; Davis, RD; Rea, JB; Palmer, SM. High frequency of bronchogenic carcinoma after single-lung transplantation. Journal of Heart and Lung Transplantation. 2006;25:1297-1301. (2006) Abstract

Martinu, T; Howell, DN; Davis, RD; Steele, MP; Palmer, SM. Pathologic correlates of bronchiolitis obliterans syndrome in pulmonary retransplant recipients. Chest. 2006;129:1016-1023. (2006) Abstract

Palmer, SM; Burch, LH; Mir, S; Smith, SR; Kuo, PC; Herczyk, WF; Reinsmoen, NL; Schwartz, DA. Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Clinical Transplantation. 2006;20:30-36. (2006) Abstract

Palmer, SM; Davis, RD; Simsir, SA; Lin, SS; Hartwig, M; Reidy, MF; Steele, MP; Eu, PC; Blumenthal, JA; Babyak, MA. Successful bilateral lung transplant outcomes in recipients 61 years of age and older. Transplantation. 2006;81:862-865. (2006) Abstract

Snyder, LD; Hartwig, MG; Ganous, T; Davis, RD; Herczyk, WF; Reinsmoen, NL; Schwartz, DA; Palmer, SM. Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant. Journal of Heart and Lung Transplantation. 2006;25:1330-1335. (2006) Abstract

Taylor, JL; Palmer, SM. Critical care perspective on immunotherapy in lung transplantation. Journal of Intensive Care Medicine. 2006;21:327-344. (2006) Abstract

Taylor, JL; Palmer, SM. Mycobacterium abscessus chest wall and pulmonary infection in a cystic fibrosis lung transplant recipient. Journal of Heart and Lung Transplantation. 2006;25:985-988. (2006) Abstract

Goldstein, DR; Palmer, SM. Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation. Journal of Heart and Lung Transplantation. 2005;24:1721-1729. (2005) Abstract

Palmer, SM; Burch, LH; Trindade, AJ; Davis, RD; Herczyk, WF; Reinsmoen, NL; Schwartz, DA. Innate immunity influences long-term outcomes after human lung transplant. American Journal of Respiratory and Critical Care Medicine. 2005;171:780-785. (2005) Abstract

Hadjiliadis, D; Steele, MP; Govert, JA; Davis, RD; Palmer, SM. Outcome of lung transplant patients admitted to the medical ICU. Chest. 2004;125:1040-1045. (2004) Abstract

Lau, CL; Patterson, GA; Palmer, SM. Critical care aspects of lung transplantation. Journal of Intensive Care Medicine. 2004;19:83-104. (2004) Abstract

Nielsen, TD; Bahnson, T; Davis, RD; Palmer, SM. Atrial fibrillation after pulmonary transplant. Chest. 2004;126:496-500. (2004) Abstract

Palmer, SM; Grinnan, DC; Diane Reams, B; Steele, MP; Messier, RH; Duane Davis, R. Delay of CMV infection in high-risk CMV mismatch lung transplant recipients due to prophylaxis with oral ganciclovir. Clinical Transplantation. 2004;18:179-185. (2004) Abstract

Davis, RD; Lau, CL; Eubanks, S; Messier, RH; Hadjiliadis, D; Steele, MP; Palmer, SM. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. Journal of Thoracic and Cardiovascular Surgery. 2003;125:533-542. (2003) Abstract

Hadjiliadis, D; Duane Davis, R; Steele, MP; Messier, RH; Lau, CL; Eubanks, SS; Palmer, SM. Gastroesophageal reflux disease in lung transplant recipients. Clinical Transplantation. 2003;17:363-368. (2003) Abstract

Palmer, SM; Burch, LH; Davis, RD; Herczyk, WF; Howell, DN; Reinsmoen, NL; Schwartz, DA. The role of innate immunity in acute allograft rejection after lung transplantation. American Journal of Respiratory and Critical Care Medicine. 2003;168:628-632. (2003) Abstract

Parekh, PI; Blumenthal, JA; Babyak, MA; Merrill, K; Carney, RM; Davis, RD; Palmer, SM; INSPIRE Investigators. Psychiatric disorder and quality of life in patients awaiting lung transplantation. Chest. 2003;124:1682-1688. (2003) Abstract

Reams, BD; McAdams, HP; Howell, DN; Steele, MP; Davis, RD; Palmer, SM. Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. Chest. 2003;124:1242-1249. (2003) Abstract

Young, LR; Hadjiliadis, D; Davis, RD; Palmer, SM. Lung transplantation exacerbates gastroesophageal reflux disease. Chest. 2003;124:1689-1693. (2003) Abstract

Hadjiliadis, D; Davis, RD; Palmer, SM. Is transplant operation important in determining posttransplant risk of bronchiolitis obliterans syndrome in lung transplant recipients?. Chest. 2002;122:1168-1175. (2002) Abstract

Hadjiliadis, D; Sporn, TA; Perfect, JR; Tapson, VF; Davis, RD; Palmer, SM. Outcome of lung transplantation in patients with mycetomas. Chest. 2002;121:128-134. (2002) Abstract

Palmer, SM; Davis, RD; Hadjiliadis, D; Hertz, MI; Howell, DN; Ward, FE; Savik, K; Reinsmoen, NL. Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome. Transplantation. 2002;74:799-804. (2002) Abstract

Reams, BD; Palmer, SM. Sublingual tacrolimus for immunosuppression in lung transplantation: a potentially important therapeutic option in cystic fibrosis. Treatments in Respiratory Medicine. 2002;1:91-98. (2002) Abstract

Garantziotis, S; Howell, DN; McAdams, HP; Davis, RD; Henshaw, NG; Palmer, SM. Influenza pneumonia in lung transplant recipients: clinical features and association with bronchiolitis obliterans syndrome. Chest. 2001;119:1277-1280. (2001) Abstract

Palmer, SM; Baz, MA; Sanders, L; Miralles, AP; Lawrence, CM; Rea, JB; Zander, DS; Edwards, LJ; Staples, ED; Tapson, VF; Davis, RD. Results of a randomized, prospective, multicenter trial of mycophenolate mofetil versus azathioprine in the prevention of acute lung allograft rejection. Transplantation. 2001;71:1772-1776. (2001) Abstract

Palmer, SM; Drew, RH; Whitehouse, JD; Tapson, VF; Davis, RD; McConnell, RR; Kanj, SS; Perfect, JR. Safety of aerosolized amphotericin B lipid complex in lung transplant recipients. Transplantation. 2001;72:545-548. (2001) Abstract

Hadjiliadis, D; Howell, DN; Davis, RD; Lawrence, CM; Rea, JB; Tapson, VF; Perfect, JR; Palmer, SM. Anastomotic infections in lung transplant recipients. Annals of transplantation: quarterly of the Polish Transplantation Society. 2000;5:13-19. (2000) Abstract

Palmer, SM; Alexander, BD; Sanders, LL; Edwards, LJ; Reller, LB; Davis, RD; Tapson, VF. Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. Transplantation. 2000;69:2360-2366. (2000) Abstract

Palmer, SM; Miralles, AP; Howell, DN; Brazer, SR; Tapson, VF; Davis, RD. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest. 2000;118:1214-1217. (2000) Abstract

Palmer, SM; Miralles, AP; Lawrence, CM; Gaynor, JW; Davis, RD; Tapson, VF. Rabbit antithymocyte globulin decreases acute rejection after lung transplantation: results of a randomized, prospective study. Chest. 1999;116:127-133. (1999) Abstract

Palmer, SM; Henshaw, NG; Howell, DN; Miller, SE; Davis, RD; Tapson, VF. Community respiratory viral infection in adult lung transplant recipients. Chest. 1998;113:944-950. (1998) Abstract

Palmer, SM; Perfect, JR; Howell, DN; Lawrence, CM; Miralles, AP; Davis, RD; Tapson, VF. Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents. Journal of Heart and Lung Transplantation. 1998;17:1029-1033. (1998) Abstract