Scott D. Moore, MD, PhD
Department / Division
Psychiatry /
Biological Psychiatry
Address
DUMC 3309
Durham, NC 27710
Appointment Telephone
919-681-8742
Office Telephone
919-681-8742
Fax Telephone
919-681-8744
- MD, PhD, University of Virginia School of Medicine, 1986
- Psychiatry, Duke University Medical Center, 1989-1992
Clinical Interests
Psychopharmacology, electroconvulsive therapy, neurobehavioral disorders
Research Interests
We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.
We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.
This faculty member has no reported relationships with industry.
Representative Publications
Barr DS, Lambert NA, Hoyt KL, Moore SD, Wilson WA: Induction and reversal of long-term potentiation by low- and high- intensity theta pattern stimulation. J. Neuroscience 15: 5402-5410, 1995.
(1995)
Moore SD, Madamba SG, Schweitzer P, Siggins GR:L Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro. Journal Neuroscience 14: 809-820, 1994.
(1994)
Moore SD, Barr DS, Wilson WA: Seizure-like activity disrupts LTP in vitra. Neuroscience Letter 163: 117-119, 1993.
(1993)
Moore SD, Madamba SG, Siggins GR: Ethanol diminishes the M-current in hippocampal pyramidal neurons. Brain Reserch 516: 222-228, 1990.
(1990)
Moore SD, Madamba SG, Joels M, Siggins GR: Somatostatin augments the M-current in hippocampus. Science 239: 278-280, 1988.
(1988)
