Department / Division:
Radiology / Nuclear Medicine

Address:
DUMC 3949
Durham, NC 27710

Appointment Telephone:
919-684-7647

Office Telephone:
919-684-7857

Fax Telephone:
919-684-7167

• MD, Federal Fluminense University, Brazil, 1981

• Cardiology, Antonio Pedro University Hospital (Brazil), 1982-1983
• Cardiology Research, Brigham and Women's Hospital/Harvard Medical School (Massachusetts), 1984-1985
• Nuclear Cardiology, Baylor College of Medicine (Texas), 1986
• Nuclear Medicine, Duke University Medical Center, 1992-1993

Clinical Interests:
Nuclear cardiology and cardiovascular imaging, the role of cardiac imaging in predicting outcomes and guiding therapy

Research Interests:
1. Combined Myocardial Perfusion SPECT imaging and First-Pass Radionuclide Angiocardiography to assess patients with suspect or known coronary artery disease.

2. Diagnostic and Prognostic utility of Cardiovascular Nuclear Medicine in coronary artery disease.

3. Pharmacological Stress Test and SPECT imaging for diagnosis and Prognosis of Patients with coronary artery disease.

Representative Publications:
Piccini JP, Starr A, Horton J, Shaw LK, Lee KL, Al-Khatib SM, Iskandrian AE, O’Connor C, Borges-Neto S.   SPECT Myocardial Perfusion Imaging and the Risk of Sudden Cardiac Death in Patients with Coronary Disease and Left Ventricular Ejection Fraction > 35%.  J Amer Coll Card.  2010. (2010)

Salerno M, Elliot L, Shaw LK, Piccini JP, Pagnanelli R, Borges-Neto S. Prognostic validation of an algorithm to convert myocardial perfusion SPECT imaging data from a 12-segment model to a 17-segment model. J Nucl Cardiol. 2009 Jul-Aug;16(4):605-13. (2009) Abstract

Driver KA, Atchley AE, Kaul P, Borges-Neto S. Single photon emission computed tomography myocardial imaging: clinical applications and future directions. Minerva Cardioangiol. 2009 Jun;57(3):333-47. (2009) Abstract

Atchley AE, Trimble MA, Samad Z, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction. J Nucl Cardiol. 2009 Nov-Dec;16(6):888-94. (2009) Abstract

Atchley AE, Kitzman DW, Whellan DJ, Iskandrian AE, Ellis SJ, Pagnanelli RA, Kao A, Abdul-Nour K, O'Connor CM, Ewald G, Kraus WE, Borges-Neto S, . Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) Trial. Am Heart J. 2009 Oct;158(4 Suppl):S53-63. (2009) Abstract

Trimble MA, Velazquez EJ, Adams GL, Honeycutt EF, Pagnanelli RA, Barnhart HX, Chen J, Iskandrian AE, Garcia EV, Borges-Neto S. Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony. Nucl Med Commun. 2008 Apr;29(4):374-81. (2008) Abstract

Trimble MA, Borges-Neto S, Velazquez EJ, Chen J, Shaw LK, Pagnanelli R, Garcia EV, Iskandrian AE. Emerging role of myocardial perfusion imaging to evaluate patients for cardiac resynchronization therapy. Am J Cardiol. 2008 Jul 15;102(2):211-7. (2008) Abstract

Trimble MA, Borges-Neto S, Honeycutt EF, Shaw LK, Pagnanelli R, Chen J, Iskandrian AE, Garcia EV, Velazquez EJ. Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. J Nucl Cardiol. 2008 Sep-Oct;15(5):663-70. (2008) Abstract

Trimble MA, Atchley A, Samad Z, Sun JL, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Borges-Neto S , Velazquez EJ.  Differences in electrical and mechanical dyssynchrony as quantified by phase analysis of gated SPECT imaging in patients with mild to moderate left ventricular dysfunction.   J Nuc Card.  2008 July; 15(4 Suppl):S27-S28. (2008)

Shaw LJ, Hendel RC, Heller GV, Borges-Neto S, Cerqueira M, Berman DS. Prognostic estimation of coronary artery disease risk with resting perfusion abnormalities and stress ischemia on myocardial perfusion SPECT. J Nucl Cardiol. 2008 Nov-Dec;15(6):762-73. (2008) Abstract

Shaw LJ, Berman DS, Hendel RC, Borges Neto S, Min JK, Callister TQ. Prognosis by coronary computed tomographic angiography: matched comparison with myocardial perfusion single-photon emission computed tomography. J Cardiovasc Comput Tomogr. 2008 Mar-Apr;2(2):93-101. (2008) Abstract

Piccini JP, Horton JR, Shaw LK, Al-Khatib SM, Lee KL, Iskandrian AE, Borges-Neto S. Single-photon emission computed tomography myocardial perfusion defects are associated with an increased risk of all-cause death, cardiovascular death, and sudden cardiac death. Circ Cardiovasc Imaging. 2008 Nov;1(3):180-8. (2008) Abstract

Chen J, Henneman MM, Trimble MA, Bax JJ, Borges-Neto S, Iskandrian AE, Nichols KJ, Garcia EV. Assessment of left ventricular mechanical dyssynchrony by phase analysis of ECG-gated SPECT myocardial perfusion imaging. J Nucl Cardiol. 2008 Jan-Feb;15(1):127-36. (2008) Abstract

Chen J, Garcia EV, Lerakis S, Henneman MM, Bax JJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE. Left ventricular mechanical dyssynchrony as assessed by phase analysis of ECG-gated SPECT myocardial perfusion imaging. Echocardiography. 2008 Nov;25(10):1186-94. (2008) Abstract

Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE. Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging. Minerva Cardioangiol. 2008 Apr;56(2):227-35. (2008) Abstract

Adams GL, Trimble MA, Brosnan RB, Russo CA, Rusband D, Honeycutt EF, Shaw LK, Hurwitz LM, Turkington TG, Hanson MW, Pagnanelli RA, Borges-Neto S. Evaluation of combined cardiac positron emission tomography and coronary computed tomography angiography for the detection of coronary artery disease. Nucl Med Commun. 2008 Jul;29(7):593-8. (2008) Abstract