Sallie R. Permar, MD, PhD
- Pediatrics / Pediatrics-Infectious Diseases
- Immunology
- Molecular Genetics and Microbiology
Address
DUMC 103020
Durham, NC 27710
Appointment Telephone
919-684-6335
Office Telephone
919-684-6335
Fax Telephone
919-668-4859
- MD, Harvard Medical School (Massachusetts), 2004
- Pediatrics, Children's Hospital Boston (Massachusetts), 2007
- Pediatric Infectious Diseases, Children's Hospital Boston (Massachusetts), 2009
- PhD, Microbiology and Immunology, Johns Hopkins University (Maryland), 2004
Clinical Interests
Prevention and treatment of neonatal viral infections; prevention and treatment of infectious diseases in immunosuppressed pediatric patients
Research Interests
Dr. Permar's work focuses on maternal correlates of immune protection against vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS, Simian Immunodeficiency Virus (SIV) infection of rhesus monkeys, to characterize the virus-specific immune responses and virus evolution in breast milk. Furthermore, the Permar lab is characterizing HIV/SIV vaccine-elicited immune responses in breast milk of vaccinated rhesus monkeys, as a platform for developing a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Finally, Dr. Permar has established studies of maternal cytomegalovirus-specific immune responses that may protect against symptomatic congenital cytomegalovirus and postnatal transmission in preterm infants.
This faculty member has no reported relationships with industry.
Representative Publications
Friedman, J; Alam, SM; Shen, X; Xia, SM; Stewart, S; Anasti, K; Pollara, J; Fouda, GG; Yang, G; Kelsoe, G; Ferrari, G; Tomaras, GD; Haynes, BF; Liao, HX; Moody, MA; Permar, SR. Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum. PLoS One. 2012;7:e37648.
(2012)
Abstract
Handley, SA; Thackray, LB; Zhao, G; Presti, R; Miller, AD; Droit, L; Abbink, P; Maxfield, LF; Kambal, A; Duan, E; Stanley, K; Kramer, J; Macri, SC; Permar, SR; Schmitz, JE; Mansfield, K; Brenchley, JM; Veazey, RS; Stappenbeck, TS; Wang, D; Barouch, DH; Virgin, HW. Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome. Cell. 2012;151:253-266.
(2012)
Abstract
Parrish, NF; Wilen, CB; Banks, LB; Iyer, SS; Pfaff, JM; Salazar-Gonzalez, JF; Salazar, MG; Decker, JM; Parrish, EH; Berg, A; Hopper, J; Hora, B; Kumar, A; Mahlokozera, T; Yuan, S; Coleman, C; Vermeulen, M; Ding, H; Ochsenbauer, C; Tilton, JC; Permar, SR; Kappes, JC; Betts, MR; Busch, MP; Gao, F; Montefiori, D; Haynes, BF; Shaw, GM; Hahn, BH; Doms, RW. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin ¿4ß7. PLoS Pathogens. 2012;8:e1002686.
(2012)
Abstract
Russell, ES; Ojeda, S; Fouda, G; Meshnick, SR; Montefiori, D; Permar, SR; Swanstrom, R. HIV-1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly-neutralizing antibodies directed against quaternary and CD4-binding site epitopes. AIDS Research and Human Retroviruses. 2012;
(2012)
Abstract
Schmitz, JE; Ma, ZM; Hagan, EA; Wilks, AB; Furr, KL; Linde, CH; Zahn, RC; Brenchley, JM; Miller, CJ; Permar, SR. Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys. Journal of Virology. 2012;86:11380-11385.
(2012)
Abstract
Ehlinger, EP; Webster, EM; Kang, HH; Cangialose, A; Simmons, AC; Barbas, KH; Burchett, SK; Gregory, ML; Puopolo, KM; Permar, SR. Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. Journal of Infectious Diseases. 2011;204:1672-1682.
(2011)
Abstract
Fouda, GG; Yates, NL; Pollara, J; Shen, X; Overman, GR; Mahlokozera, T; Wilks, AB; Kang, HH; Salazar-Gonzalez, JF; Salazar, MG; Kalilani, L; Meshnick, SR; Hahn, BH; Shaw, GM; Lovingood, RV; Denny, TN; Haynes, B; Letvin, NL; Ferrari, G; Montefiori, DC; Tomaras, GD; Permar, SR; Center for HIV/AIDS Vaccine Immunology. HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. Journal of Virology. 2011;85:9555-9567.
(2011)
Abstract
Mahlokozera, T; Kang, HH; Goonetilleke, N; Stacey, AR; Lovingood, RV; Denny, TN; Kalilani, L; Bunn, JE; Meshnick, SR; Borrow, P; Letvin, NL; Permar, SR; Center for HIV/AIDS Vaccine Immunology. The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk. PLoS One. 2011;6:e23735.
(2011)
Abstract
Salazar-Gonzalez, JF; Salazar, MG; Learn, GH; Fouda, GG; Kang, HH; Mahlokozera, T; Wilks, AB; Lovingood, RV; Stacey, A; Kalilani, L; Meshnick, SR; Borrow, P; Montefiori, DC; Denny, TN; Letvin, NL; Shaw, GM; Hahn, BH; Permar, SR; Center for HIV/AIDS Vaccine Immunology A0167854. Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. Journal of Virology. 2011;85:2751-2763.
(2011)
Abstract
Sun, Y; Asmal, M; Lane, S; Permar, SR; Schmidt, SD; Mascola, JR; Letvin, NL. Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys. Journal of Virology. 2011;85:6906-6912.
(2011)
Abstract
Wilks, AB; Perry, JR; Ehlinger, EP; Zahn, RC; White, R; Gauduin, MC; Carville, A; Seaman, MS; Schmitz, JE; Permar, SR. High cell-free virus load and robust autologous humoral immune responses in breast milk of simian immunodeficiency virus-infected african green monkeys. Journal of Virology. 2011;85:9517-9526.
(2011)
Abstract
Permar, SR; Kang, HH; Carville, A; Wilks, AB; Mansfield, KG; Rao, SS; Letvin, NL. Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection. Journal of Infectious Diseases. 2010;201:302-310.
(2010)
Abstract
Permar, SR; Kang, HH; Wilks, AB; Mach, LV; Carville, A; Mansfield, KG; Learn, GH; Hahn, BH; Letvin, NL. Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys. Retrovirology. 2010;7:7.
(2010)
Abstract
Permar, SR; Wilks, AB; Ehlinger, EP; Kang, HH; Mahlokozera, T; Coffey, RT; Carville, A; Letvin, NL; Seaman, MS. Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeys. Journal of Virology. 2010;84:8209-8218.
(2010)
Abstract
Wilks, AB; Christian, EC; Seaman, MS; Sircar, P; Carville, A; Gomez, CE; Esteban, M; Pantaleo, G; Barouch, DH; Letvin, NL; Permar, SR. Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys. Journal of Immunology. 2010;185:7097-7106.
(2010)
Abstract
Permar, SR; Kang, HH; Carville, A; Mansfield, KG; Gelman, RS; Rao, SS; Whitney, JB; Letvin, NL. Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. Journal of Immunology. 2008;181:3643-3650.
(2008)
Abstract
Permar, SR; Rao, SS; Sun, Y; Bao, S; Buzby, AP; Kang, HH; Letvin, NL. Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. Journal of Infectious Diseases. 2007;196:1784-1793.
(2007)
Abstract
Sun, Y; Permar, SR; Buzby, AP; Letvin, NL. Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. Journal of Virology. 2007;81:8009-8015.
(2007)
Abstract
Permar, SR; Griffin, DE; Letvin, NL. Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals. Clinical and Vaccine Immunology. 2006;13:437-443.
(2006)
Abstract
Permar, SR; Klumpp, SA; Mansfield, KG; Carville, AA; Gorgone, DA; Lifton, MA; Schmitz, JE; Reimann, KA; Polack, FP; Griffin, DE; Letvin, NL. Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys. Journal of Infectious Diseases. 2004;190:998-1005.
(2004)
Abstract
Permar, SR; Klumpp, SA; Mansfield, KG; Kim, WK; Gorgone, DA; Lifton, MA; Williams, KC; Schmitz, JE; Reimann, KA; Axthelm, MK; Polack, FP; Griffin, DE; Letvin, NL. Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys. Journal of Virology. 2003;77:4396-4400.
(2003)
Abstract
Permar, SR; Moss, WJ; Ryon, JJ; Douek, DC; Monze, M; Griffin, DE. Increased thymic output during acute measles virus infection. Journal of Virology. 2003;77:7872-7879.
(2003)
Abstract
Permar, SR; Moss, WJ; Ryon, JJ; Monze, M; Cutts, F; Quinn, TC; Griffin, DE. Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction. Journal of Infectious Diseases. 2001;183:532-538.
(2001)
Abstract
