Sallie R. Permar, MD, PhD
- Pediatrics / Pediatrics-Infectious Diseases
- Immunology
- Molecular Genetics and Microbiology
Address
DUMC 103020
Durham, NC 27710
Appointment Telephone
919-684-6335
Office Telephone
919-684-6335
Fax Telephone
919-668-4859
- MD, Harvard Medical School (Massachusetts), 2004
- Pediatrics, Children's Hospital Boston (Massachusetts), 2007
- Pediatric Infectious Diseases, Children's Hospital Boston (Massachusetts), 2009
- PhD, Microbiology and Immunology, Johns Hopkins University (Maryland), 2004
Clinical Interests
Prevention and treatment of neonatal viral infections; prevention and treatment of infectious diseases in immunosuppressed pediatric patients
Research Interests
Dr. Permar is an early-stage investigator focusing on maternal correlates of immune protection against vertical transmission of neonatal viral pathogens. Her work utilized the primate model of HIV/AIDS, Simian Immunodeficiency Virus (SIV) infection of rhesus monkeys, to characterize the virus-specific immune responses and virus evolution in breast milk. Furthermore, the Permar lab is characterizing HIV/SIV vaccine-elicited immune responses in breast milk of vaccinated rhesus monkeys, as a platform for developing a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, the Permar lab is studying HIV-specific immune responses and virus evolution in transmitting and nontransmitting, lactating HIV-infected women to define maternal immune responses that may protect against breast milk transmission of HIV. Finally, Dr. Permar plans to continue studies of maternal cytomegalovirus-specific immune responses that may protect against symptomatic congenital cytomegalovirus and postnatal transmission in preterm infants.
This faculty member has no reported relationships with industry.
Representative Publications
Fouda GG, Yates NL, Pollara J, Shen X, Overman GR, Mahlokozera T, Wilks AB, Kang HH, Salazar-Gonzalez JF, Salazar MG, Kalilani L, Meshnick SR, Hahn BH, Shaw GM, Lovingood RV, Denny TN, Haynes B, Letvin NL, Ferrari G, Montefiori DC, Tomaras GD, Permar SR, . HIV-Specific Functional Antibody Responses in Breast Milk Mirror Those in Plasma and Are Primarily Mediated by IgG Antibodies. J Virol. 2011 Sep;85(18):9555-9567.
(2011)
Abstract
Salazar-Gonzalez JF, Salazar MG, Learn GH, Fouda GG, Kang HH, Mahlokozera T, Wilks AB, Lovingood RV, Stacey A, Kalilani L, Meshnick SR, Borrow P, Montefiori DC, Denny TN, Letvin NL, Shaw GM, Hahn BH, Permar SR, . Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. J Virol. 2011 Mar;85(6):2751-63.
(2011)
Abstract
Sun Y, Asmal M, Lane S, Permar SR, Schmidt SD, Mascola JR, Letvin NL. Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys. J Virol. 2011 Jul;85(14):6906-12.
(2011)
Abstract
Wilks AB, Perry JR, Ehlinger EP, Zahn RC, White R, Gauduin MC, Carville A, Seaman MS, Schmitz JE, Permar SR. High cell-free virus load and robust autologous humoral immune responses in breast milk of simian immunodeficiency virus-infected african green monkeys. J Virol. 2011 Sep;85(18):9517-26.
(2011)
Abstract
Permar SR, Kang HH, Carville A, Wilks AB, Mansfield KG, Rao SS, Letvin NL. Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection. J Infect Dis. 2010 Jan 15;201(2):302-10.
(2010)
Abstract
Permar SR, Kang HH, Wilks AB, Mach LV, Carville A, Mansfield KG, Learn GH, Hahn BH, Letvin NL. Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys. Retrovirology. 2010;7:7.
(2010)
Abstract
Permar SR, Wilks AB, Ehlinger EP, Kang HH, Mahlokozera T, Coffey RT, Carville A, Letvin NL, Seaman MS. Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeys. J Virol. 2010 Aug;84(16):8209-18.
(2010)
Abstract
Wilks AB, Christian EC, Seaman MS, Sircar P, Carville A, Gomez CE, Esteban M, Pantaleo G, Barouch DH, Letvin NL, Permar SR. Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys. J Immunol. 2010 Dec 1;185(11):7097-106.
(2010)
Abstract
Permar SR, Kang HH, Carville A, Mansfield KG, Gelman RS, Rao SS, Whitney JB, Letvin NL. Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. J Immunol. 2008 Sep 1;181(5):3643-50.
(2008)
Abstract
Permar SR, Rao SS, Sun Y, Bao S, Buzby AP, Kang HH, Letvin NL. Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. J Infect Dis. 2007 Dec 15;196(12):1784-93.
(2007)
Abstract
Sun Y, Permar SR, Buzby AP, Letvin NL. Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. J Virol. 2007 Aug;81(15):8009-15.
(2007)
Abstract
Permar SR, Griffin DE, Letvin NL. Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals. Clin Vaccine Immunol. 2006 Apr;13(4):437-43.
(2006)
Abstract
Permar SR, Klumpp SA, Mansfield KG, Carville AA, Gorgone DA, Lifton MA, Schmitz JE, Reimann KA, Polack FP, Griffin DE, Letvin NL. Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys. J Infect Dis. 2004 Sep 1;190(5):998-1005.
(2004)
Abstract
Permar SR, Klumpp SA, Mansfield KG, Kim WK, Gorgone DA, Lifton MA, Williams KC, Schmitz JE, Reimann KA, Axthelm MK, Polack FP, Griffin DE, Letvin NL. Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys. J Virol. 2003 Apr;77(7):4396-400.
(2003)
Abstract
Permar SR, Moss WJ, Ryon JJ, Douek DC, Monze M, Griffin DE. Increased thymic output during acute measles virus infection. J Virol. 2003 Jul;77(14):7872-9.
(2003)
Abstract
Permar SR, Moss WJ, Ryon JJ, Monze M, Cutts F, Quinn TC, Griffin DE. Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction. J Infect Dis. 2001 Feb 15;183(4):532-8.
(2001)
Abstract
