Chair, Department of DermatologyDepartments / Divisions
Durham, NC 27710
Immunologically mediated skin diseases, blistering skin diseases (dermatitis herpetiformis, bullous pemphigoid, pemphigus, cicatricial pemphigoid), immunofluorescence testing
Our laboratory is investigating the pathogenesis of autoimmune blistering skin diseases. Areas of special expertise include immune mediated skin diseases, especially immune mediated primary blistering disorders. These include pathogenesis, diagnosis, and management.
Specifically our laboratory is investigating the role of the mucosal immune response in the pathogenesis of dermatitis herpetiformis (DH) and the role the associated gluten sensitive enteropathy (GSE) plays in the development of this disease. Studies are currently focused on understanding the systemic manifestations of the mucosal immune response to dietary ingestion of wheat proteins in patients with DH. Studies are directed at determining the pattern of cytokine activation and inflammatory cell activation in the gut, skin and circulation. These studies are focused on understanding the manner in which gastrointestinal inflammation leads to the development of skin lesions in patients with DH and will provide new insight into the pathogenesis of the numerous skin diseases associated with inflammatory gastrointestinal disease.
In addition, our laboratory is investigating the pathogenesis of the organ specific auto immune blistering diseases bullous pemphigoid, and pemphigus vulgaris. These studies are directed at understanding auto-antibody epitopes and their relationship to disease activity and the role of B cells in the development and maintaince of auto-antibodies. Clinical trials are ongoing in both pemphigus and bullous pemphigoid that are coupled with mechanistic studies.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Hall, RP; Takeuchi, F; Benbenisty, KM; Streilein, RD. Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. Journal of Investigative Dermatology. 2006;126:1331-1337. (2006) Abstract
Suarez, EC; Boyle, SH; Lewis, JG; Hall, RP; Young, KH. Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator. Brain, Behavior, and Immunity. 2006;20:331-338. (2006) Abstract
Kong, HH; Prose, NS; Ware, RE; Hall, RP. Successful treatment of refractory childhood pemphgus vulgaris with anti-CD20 monoclonal antibody (rituximab). Pediatric Dermatology. 2005;22:461-464. (2005) Abstract
Whited, JD; Hall, RP; Foy, ME; Marbrey, LE; Grambow, SC; Dudley, TK; Datta, SK; Simel, DL; Oddone, EZ. Patient and clinician satisfaction with a store-and-forward teledermatology consult system. Telemedicine and e-Health. 2004;10:422-431. (2004) Abstract
Takeuchi, F; Sterilein, RD; Hall, RP. Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma. Experimental Dermatology. 2003;12:777-783. (2003) Abstract
Smith, AD; Streilein, RD; Hall, RP. Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis. British Journal of Dermatology. 2002;147:1109-1117. (2002) Abstract
Szabolcs, P; Reese, M; Yancey, KB; Hall, RP; Kurtzberg, J. Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. Bone Marrow Transplantation. 2002;30:327-329. (2002) Abstract
Hall, RP; Owen, S; Smith, A; Keough, M; Bagheri, B; Church, P; Streilein, R. TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy. Experimental Dermatology. 2000;9:275-282. (2000) Abstract
Hall, RP; Smith, AD; Streilein, RD. Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy. Digestive Diseases and Sciences. 2000;45:2036-2043. (2000) Abstract
Roh, JY; Yee, C; Lazarova, Z; Hall, RP; Yancey, KB. The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis. British Journal of Dermatology. 2000;143:104-111. (2000) Abstract
Rico, MJ; Benning, C; Weingart, ES; Streilein, RD; Hall, RP. Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris. British Journal of Dermatology. 1999;140:1079-1086. (1999) Abstract
Smith, AD; Bagheri, B; Streilein, RD; Hall, RP. Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy. Digestive Diseases and Sciences. 1999;44:2124-2132. (1999) Abstract
Ishii, K; Amagai, M; Hall, RP; Hashimoto, T; Takayanagi, A; Gamou, S; Shimizu, N; Nishikawa, T. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. Journal of Immunology. 1997;159:2010-2017. (1997) Abstract
Rico, MJ; Hashimototo, T; Watanabe, K; Hall, RP; Clark, RB; Nishikawa, T. Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1. Journal of Dermatological Science. 1996;12:238-245. (1996) Abstract