Physicians

Medical Director, Duke Sleep Disorders Laboratory

Department / Division
Medicine / Medicine-Neurology

Address
DUMC 102350
297 Hanes House
Durham, NC 27710

Appointment Telephone
919-668-7600

Office Telephone
919-681-3448

Fax Telephone
919-684-8955

Training

• MD, Northwestern University Feinberg School of Medicine (Illinois), 1980

Residency

• Neurology, Duke University Medical Center, 1981-1984

Clinical Interests
Epilepsy (medical and surgical treatment), sleep disorders (particularly hypersomnolence), EEG, evoked potentials, epilepsy monitoring, intraoperative neurophysiologic monitoring

Research Interests
Main focus is in epilepsy, sleep disorders, and clinical neurophysiology interpretation. Specific areas of interest include predictive outcome factors in epilepsy surgery, neuroimaging characteristics of neuronal migration disorders, development of new medical treatments of epilepsy and narcolepsy, and the pharmacogenetics of epilepsy and its treatment.

No involvement in basic laboratory research.

Ongoing clinical trials include:
1) Pharmacogenetics of epilepsy  
2)  behavioral treatment trial for insomnia

Special expertise recognized by serving on Professional Advisory Board of the Epilepsy Foundation of America and election as chairman of the American Board of Clinical Neurophysiology (certifying body in EEG, Evoked Potentials, Epilepsy Monitoring and Sleep).

Key words:  Epilepsy
 Epilepsy Surgery
 Sleep Disorders
 Sleep Apnea
 Narcolepsy
 Clinical Neurophysiology

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• GlaxoSmithKline
• UCB Pharma

Representative Publications
Radtke RA. Sleep Disorders: Laboratory Evaluation. In: Current Practice of Clinical EEG. Pedley TA, Ebersole J (eds, 2002.

Gibbs JW, Ciafaloni E, Radtke RA. Excessive Daytime Somnolence and Increased REM Pressure in Myotonic Dystrophy. Sleep 25(6):672-675, 2002. (2002)

Lee N, Tien RD, Lewis DV, Friedman AH, Felsberg GJ, Crain B, Hulette C, Osumi AK, VanLandingham KE, Radtke RA. Fast Spin-Echo MRI-measured Absolute Hippocampal Volume: Correlation with Neuronal Density in Temporal Lobectomy Patients. Epilepsia 36(9):899-904, 1995. (1995)

Lee N, Radtke RA, Gray L, Burger PC, Montine TJ, DeLong GR, Lewis DV, Oakes WJ, Friedman AH, Hoffman JM. Neuronal Migration Disorders: PET Correlations. Annals of Neurology 35:290-297, 1994. (1994)

Radtke RA, Hanson MW, Hoffman JM, Crain BJ, Walczak TS, Lewis DV, Coleman RE, Friedman AH. Temporal Lobe Hypometabolism on PET: Predictor of Seizure Control after Temporal Lobectomy. Neurology 43:1088-92, 1993. (1993)

Radtke RA, Erwin CW, Wilkins RH. Intraoperative Brainstem Evoked Potentials (BAEPs): Significant Decrease in Postoperative Auditory Deficit. Neurology 39:187-192, 1989. Abstracted in: Key Neurology Neurosurgery 1989. Abstracted in Yearbook of Neurology and Neurosurgery 1990. (1989)