Department / Division
Medicine / Medicine-Pulmonary
Durham, NC 27710
Interstitial lung disease, idiopathic pulmonary fibrosis, COPD, asthma, evaluation of lung masses
My research interest is to identify and characterize macrophage sub-populations after lung injury in order to understand their role in the initiation and resolution of injury. This work has focused on two injury models using bleomycin and ozone. We have identifed both resident and recruited macrophages in the lung defined using flow cytometry both of which have unique functions from the other.
In addition I have developed a research interest to understand the role of arginase-1 in the development of experimental pulmonary fibrosis. This research utilizes a floxed/cre recombinase system which targets arginase-1 expression in macrophages and fibroblasts within the lung. We hope to determine if arginase-1 plays a role in the development of pulmonary fibrosis which may lead to enhanced therapeutics.
This faculty member has no reported relationships with industry.