Physicians

Director, Duke Translational Medicine Institute
Vice Chancellor for Clinical and Translational Research

Department / Division
Medicine / Medicine - Cardiology

Address
DUMC 3701
Durham, NC 27710

200 Trent Drive, 1117 Davison Building
Durham, NC 27710

Appointment Telephone
919-681-5816

Office Telephone
919-668-8820

Fax Telephone
919-668-7103

Training

• MD, Duke University School of Medicine, 1978

Residency

• Medicine, University of California–San Francisco Medical Center, 1979-1980
• Cardiology, Duke University Medical Center, 1980-1983

Clinical Interests
Chronic coronary artery disease, heart failure, acute coronary syndromes

Research Interests
Robert Califf, MD, is the Donald F. Fortin, MD, Professor of Cardiology, Vice Chancellor for Clinical Research and Director of the Duke Translational Medicine Institute. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf has led some of the best-known clinical trials and health outcomes studies in cardiovascular medicine and has published over 1,000 peer reviewed original articles in collaboration with his colleagues. He is currently the 7th most frequently cited author in the field of medicine globally according to the ISI. He is considered a leader in the fields of quality of care, technology development and health policy. He has served on numerous committees and panels assisting in the development of health policy including the Cardiorenal Panel of the FDA and multiple Institute of Medicine Committees, including the Committee on Identifying and Preventing Medication Errors, the Forum on Drug Discovery and Translation and the Science Board of the FDA. He was the founding Director of the Coordinating Center for the Centers for Education and Research in Therapeutics (CERTs), a public/private partnership focused on the safety of medical products. After 10 years as founding director of the DCRI he has founded the Duke Translational Medicine Institute, which encompasses the spectrum of translational research at Duke.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Amilyn
• Aterovax
• Bayer
• Bristol Myers Squibb
• CV Sight
• Gambro
• Gilead Sciences, Inc.
• Hoffman LaRoche (Roche Holding)
• Kowa Research Institute, Inc.
• Merck
• N30 Pharma
• Nile Therapeutics
• Novartis
• Orexigen Therapeutics, Inc.
• Pfizer Inc.
• Portola
• Pozen
• Regeneron Pharmaceuticals
• Sankyo Co. (Daiichi Sankyo)/Eli Lilly
• Scios, Inc. (Johnson & Johnson)
• Servier INternational

Representative Publications
DeMets, DL; Califf, RM. A historical perspective on clinical trials innovation and leadership: where have the academics gone?. JAMA: Journal of the American Medical Association. 2011;305:713-714. (2011) Abstract

Vamadevan, AS; Shah, BR; Califf, RM; Prabhakaran, D. Cardiovascular research in India: a perspective. American Heart Journal. 2011;161:431-438. (2011) Abstract

Zarin, DA; Tse, T; Williams, RJ; Califf, RM; Ide, NC. The ClinicalTrials.gov results database--update and key issues. New England Journal of Medicine. 2011;364:852-860. (2011) Abstract

Califf, RM; Armstrong, PW; Granger, CB; Harrington, RA; Lee, K; Simes, RJ; Van de Werf, F; Wallentin, L; White, HD; Virtual Coordinating Centre for Global Collaborative Cardiovascular Research Organization. Towards a new order in cardiovascular medicine: re-engineering through global collaboration. European Heart Journal. 2010;31:911-917. (2010) Abstract

Califf, RM; Berglund, L; Principal Investigators of National Institutes of Health Clinical and Translational Science Awards. Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards. Academic Medicine. 2010;85:457-462. (2010) Abstract

Dzau, VJ; Ackerly, DC; Sutton-Wallace, P; Merson, MH; Williams, RS; Krishnan, KR; Taber, RC; Califf, RM. The role of academic health science systems in the transformation of medicine. Lancet. 2010;375:949-953. (2010) Abstract

Harrington, RA; Califf, RM. There is a role for industry-sponsored education in cardiology. Circulation. 2010;121:2221-2227. (2010) Abstract

NAVIGATOR Study Group, ; Holman, RR; Haffner, SM; McMurray, JJ; Bethel, MA; Holzhauer, B; Hua, TA; Belenkov, Y; Boolell, M; Buse, JB; Buckley, BM; Chacra, AR; Chiang, FT; Charbonnel, B; Chow, CC; Davies, MJ; Deedwania, P; Diem, P; Einhorn, D; Fonseca, V; Fulcher, GR; Gaciong, Z; Gaztambide, S; Giles, T; Horton, E; Ilkova, H; Jenssen, T; Kahn, SE; Krum, H; Laakso, M; Leiter, LA; Levitt, NS; Mareev, V; Martinez, F; Masson, C; Mazzone, T; Meaney, E; Nesto, R; Pan, C; Prager, R; Raptis, SA; Rutten, GE; Sandstroem, H; Schaper, F; Scheen, A; Schmitz, O; Sinay, I; Soska, V; Stender, S; Tamás, G; Tognoni, G; Tuomilehto, J; Villamil, AS; Vozár, J; Califf, RM. Effect of nateglinide on the incidence of diabetes and cardiovascular events. New England Journal of Medicine. 2010;362:1463-1476. (2010) Abstract

NAVIGATOR Study Group, ; McMurray, JJ; Holman, RR; Haffner, SM; Bethel, MA; Holzhauer, B; Hua, TA; Belenkov, Y; Boolell, M; Buse, JB; Buckley, BM; Chacra, AR; Chiang, FT; Charbonnel, B; Chow, CC; Davies, MJ; Deedwania, P; Diem, P; Einhorn, D; Fonseca, V; Fulcher, GR; Gaciong, Z; Gaztambide, S; Giles, T; Horton, E; Ilkova, H; Jenssen, T; Kahn, SE; Krum, H; Laakso, M; Leiter, LA; Levitt, NS; Mareev, V; Martinez, F; Masson, C; Mazzone, T; Meaney, E; Nesto, R; Pan, C; Prager, R; Raptis, SA; Rutten, GE; Sandstroem, H; Schaper, F; Scheen, A; Schmitz, O; Sinay, I; Soska, V; Stender, S; Tamás, G; Tognoni, G; Tuomilehto, J; Villamil, AS; Vozár, J; Califf, RM. Effect of valsartan on the incidence of diabetes and cardiovascular events. New England Journal of Medicine. 2010;362:1477-1490. (2010) Abstract

Califf, RM. A virtuous cycle to improve hypertension outcomes at a national level: linking public health and individualized medicine. Hypertension. 2009;53:105-107. (2009) Abstract

Califf, RM. Clinical research sites--the underappreciated component of the clinical research system. JAMA: Journal of the American Medical Association. 2009;302:2025-2027. (2009) Abstract

Califf, RM. Rational use of medications: if Canada can't do it ... CMAJ. 2009;181:15-16. (2009) Abstract

Califf, RM; Harrington, RA; Blazing, MA. Premature release of data from clinical trials of ezetimibe. New England Journal of Medicine. 2009;361:712-717. (2009) Abstract

Califf, RM; Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (VIGOUR) organisation. Key issues for global cardiovascular medicine. Lancet. 2009;374:508-510. (2009) Abstract

Coller, BS; Califf, RM. Traversing the valley of death: a guide to assessing prospects for translational success. Science Translational Medicine. 2009;1:10cm9. (2009) Abstract

Al-Khatib, SM; Sanders, GD; Bigger, JT; Buxton, AE; Califf, RM; Carlson, M; Curtis, A; Curtis, J; Fain, E; Gersh, BJ; Gold, MR; Haghighi-Mood, A; Hammill, SC; Healey, J; Hlatky, M; Hohnloser, S; Kim, RJ; Lee, K; Mark, D; Mianulli, M; Mitchell, B; Prystowsky, EN; Smith, J; Steinhaus, D; Zareba, W; Expert panel participating in a Duke's Center for the Prevention of Sudden Cardiac Death conference. Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death. American Heart Journal. 2007;153:941-950. (2007) Abstract

Al-Khatib, SM; Shaw, LK; O'Connor, C; Kong, M; Califf, RM. Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. Journal of Cardiovascular Electrophysiology. 2007;18:1231-1235. (2007) Abstract

Anderson, JL; Adams, CD; Antman, EM; Bridges, CR; Califf, RM; Casey, DE; Chavey, WE; Fesmire, FM; Hochman, JS; Levin, TN; Lincoff, AM; Peterson, ED; Theroux, P; Wenger, NK; Wright, RS; Smith, SC; Jacobs, AK; Adams, CD; Anderson, JL; Antman, EM; Halperin, JL; Hunt, SA; Krumholz, HM; Kushner, FG; Lytle, BW; Nishimura, R; Ornato, JP; Page, RL; Riegel, B; American College of Cardiology, ; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction), ; American College of Emergency Physicians, ; Society for Cardiovascular Angiography and Interventions, ; Society of Thoracic Surgeons, ; American Association of Cardiovascular and Pulmonary Rehabilitation, ; . . . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Journal of the American College of Cardiology. 2007;50:e1-e157. (2007) Abstract

Anderson, JL; Adams, CD; Antman, EM; Bridges, CR; Califf, RM; Casey, DE; Chavey, WE; Fesmire, FM; Hochman, JS; Levin, TN; Lincoff, AM; Peterson, ED; Theroux, P; Wenger, NK; Wright, RS; Smith, SC; Jacobs, AK; Halperin, JL; Hunt, SA; Krumholz, HM; Kushner, FG; Lytle, BW; Nishimura, R; Ornato, JP; Page, RL; Riegel, B; American College of Cardiology, ; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction), ; American College of Emergency Physicians, ; Society for Cardiovascular Angiography and Interventions, ; Society of Thoracic Surgeons, ; American Association of Cardiovascular and Pulmonary Rehabilitation, ; Society for Academic Emergency Medici. . . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 2007;116:e148-e304. (2007) Abstract

Barbagelata, A; Perna, ER; Clemmensen, P; Uretsky, BF; Canella, JP; Califf, RM; Granger, CB; Adams, GL; Merla, R; Birnbaum, Y. Time to reperfusion in acute myocardial infarction. It is time to reduce it!. Journal of Electrocardiology. 2007;40:257-264. (2007) Abstract

Bennett-Guerrero, E; Veldman, TH; Doctor, A; Telen, MJ; Ortel, TL; Reid, TS; Mulherin, MA; Zhu, H; Buck, RD; Califf, RM; McMahon, TJ. Evolution of adverse changes in stored RBCs. Proceedings of the National Academy of Sciences of USA. 2007;104:17063-17068. (2007) Abstract

Califf, RM; CERTs Benefit Assessment Workshop Participants. Benefit assessment of therapeutic products: the Centers for Education and Research on Therapeutics. Pharmacoepidemiology and Drug Safety. 2007;16:5-16. (2007) Abstract

Califf, RM; Harrington, RA; Madre, LK; Peterson, ED; Roth, D; Schulman, KA. Curbing the cardiovascular disease epidemic: aligning industry, government, payers, and academics. Health Affairs. 2007;26:62-74. (2007) Abstract

Califf, RM; Mehta, RH; Peterson, ED. Clinical quality in non-ST-elevation acute coronary syndromes. American Journal of Medicine. 2007;120:930-935. (2007) Abstract

Echols, MR; Mahaffey, KW; Banerjee, A; Pieper, KS; Stebbins, A; Lansky, A; Cohen, MG; Velazquez, E; Santos, R; Newby, LK; Gurfinkel, EP; Biasucci, L; Ferguson, JJ; Califf, RM. Racial differences among high-risk patients presenting with non-ST-segment elevation acute coronary syndromes (results from the SYNERGY trial). American Journal of Cardiology. 2007;99:315-321. (2007) Abstract

Eisenstein, EL; Anstrom, KJ; Kong, DF; Shaw, LK; Tuttle, RH; Mark, DB; Kramer, JM; Harrington, RA; Matchar, DB; Kandzari, DE; Peterson, ED; Schulman, KA; Califf, RM. Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA: Journal of the American Medical Association. 2007;297:159-168. (2007) Abstract

Goyal, A; Alexander, JH; Hafley, GE; Graham, SH; Mehta, RH; Mack, MJ; Wolf, RK; Cohn, LH; Kouchoukos, NT; Harrington, RA; Gennevois, D; Gibson, CM; Califf, RM; Ferguson, TB; Peterson, ED; PREVENT IV Investigators. Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery. Annals of Thoracic Surgery. 2007;83:993-1001. (2007) Abstract

Hasselblad, V; Gattis Stough, W; Shah, MR; Lokhnygina, Y; O'Connor, CM; Califf, RM; Adams, KF. Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. European Journal of Heart Failure. 2007;9:1064-1069. (2007) Abstract

Hernández, AV; Westerhout, CM; Steyerberg, EW; Ioannidis, JP; Bueno, H; White, H; Theroux, P; Moliterno, DJ; Armstrong, PW; Califf, RM; Wallentin, LC; Simoons, ML; Boersma, E. Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST segment elevation acute coronary syndromes: benefit and harm in different age subgroups. Heart. 2007;93:450-455. (2007) Abstract

Jiang, W; Kuchibhatla, M; Clary, GL; Cuffe, MS; Christopher, EJ; Alexander, JD; Califf, RM; Krishnan, RR; O'Connor, CM. Relationship between depressive symptoms and long-term mortality in patients with heart failure. American Heart Journal. 2007;154:102-108. (2007) Abstract

Li, JS; Eisenstein, EL; Grabowski, HG; Reid, ED; Mangum, B; Schulman, KA; Goldsmith, JV; Murphy, MD; Califf, RM; Benjamin, DK. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA: Journal of the American Medical Association. 2007;297:480-488. (2007) Abstract

Li, JS; Yow, E; Berezny, KY; Rhodes, JF; Bokesch, PM; Charpie, JR; Forbus, GA; Mahony, L; Boshkov, L; Lambert, V; Bonnet, D; Michel-Behnke, I; Graham, TP; Takahashi, M; Jaggers, J; Califf, RM; Rakhit, A; Fontecave, S; Sanders, SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?. Circulation. 2007;116:293-297. (2007) Abstract

Mahaffey, KW; Roe, MT; Kilaru, R; Alexander, JH; Van de Werf, F; Califf, RM; Simoons, ML; Topol, EJ; Harrington, RA. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. European Heart Journal. 2007;28:425-432. (2007) Abstract

Mark, DB; Van de Werf, FJ; Simes, RJ; White, HD; Wallentin, LC; Califf, RM; Armstrong, PW; VIGOUR Group. Cardiovascular disease on a global scale: defining the path forward for research and practice. European Heart Journal. 2007;28:2678-2684. (2007) Abstract