Division HeadDepartments / Divisions
Durham, NC 27710
Psychosomatic disease, stress management, obesity, diabetes, eating disorders
Our research program is focused the role of stress, depression and personality variables in the etiology and treatment of diabetes mellitus. We have recently finished a large clinical trial of stress-management in the treatment of type 2 diabetes that demonstrated that a brief, group, stress management intervention can improve long-term glycemic control in a large sample of patients with type 2 diabetes. In addition we have two other projects currently ongoing. The first is concerned with the impact of a cognitive behavioral program in the treatment of diabetes. Extensive literature documents increased incidence of depression in patients with diabetes mellitus. However, the degree to which the treatment of depression impacts on diabetes control is not clear. Some investigators have found a strong association between depression and diabetes control, while others have found a week assocation. A review of existing literature as well as preliminary data from our laboratory suggest that this discrepancy may be due, in part from failure of many studies to clearly differentiate type 1 and type type 2 diabetes in their patient samples. The strongest association between depression and diabetes control has been reported in studies of patients with type 1 diabetes. Preliminary data from our group suggests that the Beck Depression Inventory (BDI) scores may be more significantly related to hemoglobin A1c (HbA1c) in type 1, than in type 2, diabetes mellitus. Studies assessing the effects of pharmacologic antidepressant therapy on diabetes have been confounded by the combined use of both diagnostic categories as well as by the direct metabolic effects of most anitidepressant drugs. An emerging literature on the use of Cognitive Behavior Therapy (CBT) suggests that improving affect through behavioral intervention can improve diabetes control, particularly in type 1 patients. The overall aim of this project is to determine if CBT differentially improves glucose control in type 1 and type 2 diabetes patients. We hypothesize that CBT will produce a greater reduction in HbA1c in type 1 diabetes than in type 2 diabetes and that CBT-induced improvement in HbA1c is mediated by an improvement in depression. We will measure the effects of CBT on changes in HbA1c and daily blood glucose in a sample of 150 depressed patients with type 1 and type 2 diabetes over one year. To evaluate the mechanism by which CBT-induced changes in depression affect blood glucose, we will determine the role of cortisol and the role of diabetes self-care behaviors as mediating variables. Changes in cortisol and self-care are predicated to impact blood glucose levels to a greater extent in type 1 diabetes because these individuals are metabolically more sensitive to any variation.
The second major focus of our research program is to evaluate whether the apparent differential relationship between the personality construct of hostility and glucose metabolism in blacks and whites might contribute to the racial disparity in the prevalence of 2 diabetes. African-Americans are at increased risk for developing type 2 diabetes, but the reasons for this racial disparity are poorly understood. We are exploring our previous finding of a differential relationship of hostility to glucose metabolism in African-Americans and Caucasians and determine the underlying behavioral and/or physiologic mechanisms of these relationships. Two studies are being undertaken. First, we are assessing the multi-factorial nature of hostility in 100 African American men, 100 African American women, 100 Caucasian men, and 100 Caucasian women. These measures will be examined in relation to fasting and two-hour post-prandial glucose and insulin and hemoglobin A1c (HbA1c) on all subjects. This study should allow us to further understand the personality variables most directly related to glucose metabolism and to investigate the possibility that race and sex interact in determ
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