Physicians

Department / Division
Pediatrics / Pediatrics-Neonatology

Address
DUMC 3373
Durham, NC 27710

Appointment Telephone
919-668-2300

Office Telephone
919-681-6035

Fax Telephone
919-668-3361

Training

• MD, University of North Carolina at Chapel Hill School of Medicine, 1981

Residency

• Pediatrics, University of Rochester Medical Center (New York), 1981-1984

Fellowship

• Neonatal Medicine, University of Rochester Medical Center (New York), 1987-1990

Clinical Interests
Critically ill newborns, newborns with congenital malformations, severe respiratory failure, ECMO, high-frequency ventilation, nitric oxide

Research Interests
Laboratory Investigations
Inflammation and oxidative stress impair perinatal alveolar and airway development. We are using transgenic mouse models and pharmacologic blockade of leukocyte influx and functions to study the pathogenesis of bronchopulmonary dysplasia.

Prenatal environmental exposures are linked to later respiratory morbidity in children and adults. We are studying how complex maternal and neonatal air pollutant exposures and non-chemical stressors affect postnatal lung and nervous system development and function using animal models, as part of an EPA-funded Children's Environmental Health Center.

Nitric oxide-sensitive pathways regulate pre- and post-natal lung development but may do so through S-nitrosation in addition to or instead of through activation of guanylyl cyclase.  We are studying S-nitrosation-dependent pathways important to postnatal lung development, and the physical and biochemical barriers to and regulators of inhaled nitric oxide and inhaled S-nitrosothiol-based treatments.
   
Clinical/Applied
We are studying inhaled nitric oxide and O-nitrosoethanol as modulators of inflammation and injury in the respiratory and nervous systems.

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Auten RL, Gilmour MI, Krantz QT, Potts EN, Mason SN, Foster WM. Maternal Diesel Inhalation Increases Airway Hyperreactivity in Ozone Exposed Offspring. Am J Respir Cell Mol Biol. 2011 Nov 3. (2011) Abstract

Sheng H, Reynolds JD, Auten RL, Demchenko IT, Piantadosi CA, Stamler JS, Warner DS. Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage. Stroke. 2011 Feb;42(2):471-6. (2011) Abstract

Brahmajothi MV, Mason SN, Whorton AR, McMahon TJ, Auten RL. Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. Free Radic Biol Med. 2010 Apr 24. (2010) Abstract

Schultz ED, Potts EN, Mason SN, Foster WM, Auten RL. Mast Cells Mediate Hyperoxia-Induced Airway Hyper-reactivity in Newborn Rats. Pediatr Res. 2010 Apr 7. (2010) Abstract

Auten RL, Mason SN, Auten KM, Brahmajothi M. Hyperoxia Impairs Postnatal Alveolar Epithelial Development via NADPH oxidase in Newborn Mice. Am J Physiol Lung Cell Mol Physiol. 2009 May 1. (2009) Abstract

Auten RL, Potts EN, Mason SN, Fischer B, Huang Y, Foster WM. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice.  Am J Respir Crit Care Med.  2009 Dec 15;180(12):1218-26. (2009) Abstract

Marshall HE, Potts EN, Kelleher ZT, Stamler JS, Foster WM, Auten RL. Protection from LPS-Induced Lung Injury by Augmentation of Airway S-Nitrosothiols. Am J Respir Crit Care Med. 2009 Mar 26. (2009) Abstract

Rawlins EL, Okubo T, Xue Y, Brass DM, Auten RL, Hasegawa H, Wang F, Hogan BL. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.  Cell Stem Cell.  2009 Jun 5;4(6):525-34. (2009) Abstract

Granillo OM, Brahmajothi MV, Li S, Whorton AR, Mason SN, McMahon TJ, Auten RL. Pulmonary Alveolar Epithelial Uptake of S-nitrosothiols is Regulated by L-Type Amino Acid Transporter.  Am J Physiol Lung Cell Mol Physiol.  2008 Apr 25. (2008) Abstract

Auten RL, Mason SN, Whorton MH, Lampe WR, Foster WM, Goldberg RN, Li B, Stamler JS, Auten KM. Inhaled Ethyl Nitrite Prevents Hyperoxia-Impaired Postnatal Alveolar Development in Newborn Rats.  Am J Respir Crit Care Med.  2007 May 3. (2007) Abstract

Auten RL, O'Reilly MA, Oury TD, Nozik-Grayck E, Whorton MH. Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L32-40. (2006) Abstract

Kinsella JP, Cutter GR, Walsh WF, Gerstmann DR, Bose CL, Hart C, Sekar KC, Auten RL, Bhutani VK, Gerdes JS, George TN, Southgate WM, Carriedo H, Couser RJ, Mammel MC, Hall DC, Pappagallo M, Sardesai S, Strain JD, Baier M, Abman SH. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med. 2006 Jul 27;355(4):354-64. (2006) Abstract

Liao L, Ning Q, Li Y, Wang W, Wang A, Wei W, Liu X, Auten RL, Tanswell AK, Luo X. CXCR2 blockade reduces radical formation in hyperoxia-exposed newborn rat lung. Pediatr Res. 2006 Sep;60(3):299-303. (2006) Abstract

Vozzelli MA, Mason SN, Whorton MH, Auten RL Jr. Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L488-93. (2004) Abstract

Ahmed MN, Suliman HB, Folz RJ, Nozik-Grayck E, Golson ML, Mason SN, Auten RL. Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. Am J Respir Crit Care Med. 2003 Feb 1;167(3):400-5. (2003) Abstract

Auten RL, Whorton MH, Nicholas Mason S. Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. Am J Respir Cell Mol Biol. 2002 Apr;26(4):391-7. (2002) Abstract

Auten RL Jr, Mason SN, Tanaka DT, Welty-Wolf K, Whorton MH. Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L336-44. (2001) Abstract

Auten RL, Richardson RM, White JR, Mason SN, Vozzelli MA, Whorton MH. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5. (2001) Abstract

Deng H, Mason SN, Auten RL Jr. Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. Am J Respir Crit Care Med. 2000 Dec;162(6):2316-23. (2000) Abstract

Allred TF, Mercer RR, Thomas RF, Deng H, Auten RL. Brief 95% O2 exposure effects on surfactant protein and mRNA in rat alveolar and bronchiolar epithelium. Am J Physiol. 1999 Jun;276(6 Pt 1):L999-L1009. (1999) Abstract

Hudak ML, Farrell EE, Rosenberg AA, Jung AL, Auten RL, Durand DJ, Horgan MJ, Buckwald S, Belcastro MR, Donohue PK, Carrion V, Maniscalco WW, Balsan MJ, Torres BA, Miller RR, Jansen RD, Graeber JE, Laskay KM, Matteson EJ, Egan EA, Brody AS, Martin DJ, Riddlesberger MM, Montgomery P. A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome. J Pediatr. 1996 Mar;128(3):396-406. (1996) Abstract

Clyde BL, Chang LY, Auten RL, Ho YS, Crapo JD. Distribution of manganese superoxide dismutase mRNA in normal and hyperoxic rat lung. Am J Respir Cell Mol Biol. 1993 May;8(5):530-7. (1993) Abstract

Auten RL, Notter RH, Kendig JW, Davis JM, Shapiro DL. Surfactant treatment of full-term newborns with respiratory failure. Pediatrics. 1991 Jan;87(1):101-7. (1991) Abstract

Horowitz S, Watkins RH, Auten RL Jr, Mercier CE, Cheng ER. Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types of hyperoxic lung. Am J Respir Cell Mol Biol. 1991 Dec;5(6):511-5. (1991) Abstract

Auten RL, Watkins RH, Shapiro DL, Horowitz S. Surfactant apoprotein A (SP-A) is synthesized in airway cells. Am J Respir Cell Mol Biol. 1990 Nov;3(5):491-6. (1990) Abstract