Physicians

Department / Division
Pediatrics / Pediatrics-Neonatology

Address
DUMC 3373
Durham, NC 27710

Appointment Telephone
919-668-2300

Office Telephone
919-681-6035

Fax Telephone
919-668-3361

Training

• MD, University of North Carolina–Chapel Hill School of Medicine, 1981

Residency

• Pediatrics, University of Rochester Medical Center (New York), 1981-1984

Fellowship

• Neonatal Medicine, University of Rochester Medical Center (New York), 1987-1990

Clinical Interests
Critically ill newborns, newborns with congenital malformations, severe respiratory failure, ECMO, high-frequency ventilation, nitric oxide

Research Interests
Laboratory Investigations
Inflammation and oxidative stress impair perinatal alveolar and airway development. We are using transgenic mouse models and pharmacologic blockade of leukocyte influx and functions to study the pathogenesis of bronchopulmonary dysplasia.

Prenatal environmental exposures are linked to later respiratory morbidity in children and adults. We are studying how complex maternal and neonatal air pollutant exposures and non-chemical stressors affect postnatal lung and nervous system development and function using animal models, as part of an EPA-funded Children's Environmental Health Center.

We are studying S-nitrosation-dependent pathways important to postnatal lung development, and the physical and biochemical barriers to and regulators of inhaled nitric oxide and inhaled S-nitrosothiol-based treatments for bronchopulmonary dysplasia and pulmonary hypertension.

Clinical/Applied
· inhaled nitric oxide and O-nitrosoethanol as modulators of inflammation and injury in the respiratory and nervous systems
· management of pulmonary hypertension

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Kline and Specter, PC

Representative Publications
Brahmajothi, MV; Sun, NZ; Auten, RL. S-nitrosothiol transport via PEPT2 mediates biological effects of nitric oxide gas exposure in macrophages. American Journal of Respiratory Cell and Molecular Biology. 2013;48:230-239. (2013) Abstract

Miranda, ML; Edwards, SE; Chang, HH; Auten, RL. Proximity to roadways and pregnancy outcomes. Journal of Exposure Science and Environmental Epidemiology. 2013;23:32-38. (2013) Abstract

Auten, RL; Gilmour, MI; Krantz, QT; Potts, EN; Mason, SN; Foster, WM. Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring. American Journal of Respiratory Cell and Molecular Biology. 2012;46:454-460. (2012) Abstract

Bolton, JL; Smith, SH; Huff, NC; Gilmour, MI; Foster, WM; Auten, RL; Bilbo, SD. Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. The FASEB Journal. 2012;26:4743-4754. (2012) Abstract

Torok, JA; Brahmajothi, MV; Zhu, H; Tinch, BT; Auten, RL; McMahon, TJ. Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport. American Journal of Respiratory Cell and Molecular Biology. 2012;47:37-43. (2012) Abstract

Kelleher, ZT; Potts, EN; Brahmajothi, MV; Foster, MW; Auten, RL; Foster, WM; Marshall, HE. NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2011;301:L327-L333. (2011) Abstract

Sheng, H; Reynolds, JD; Auten, RL; Demchenko, IT; Piantadosi, CA; Stamler, JS; Warner, DS. Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage. Stroke. 2011;42:471-476. (2011) Abstract

Brahmajothi, MV; Mason, SN; Whorton, AR; McMahon, TJ; Auten, RL. Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. Free Radical Biology and Medicine. 2010;49:294-300. (2010) Abstract

Schultz, ED; Potts, EN; Mason, SN; Foster, WM; Auten, RL. Mast cells mediate hyperoxia-induced airway hyper-reactivity in newborn rats. Pediatric Research. 2010;68:70-74. (2010) Abstract

Auten, RL; Mason, SN; Auten, KM; Brahmajothi, M. Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2009;297:L134-L142. (2009) Abstract

Auten, RL; Potts, EN; Mason, SN; Fischer, B; Huang, Y; Foster, WM. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. American Journal of Respiratory and Critical Care Medicine. 2009;180:1218-1226. (2009) Abstract

Marshall, HE; Potts, EN; Kelleher, ZT; Stamler, JS; Foster, WM; Auten, RL. Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols. American Journal of Respiratory and Critical Care Medicine. 2009;180:11-18. (2009) Abstract

Rawlins, EL; Okubo, T; Xue, Y; Brass, DM; Auten, RL; Hasegawa, H; Wang, F; Hogan, BL. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell. 2009;4:525-534. (2009) Abstract

Granillo, OM; Brahmajothi, MV; Li, S; Whorton, AR; Mason, SN; McMahon, TJ; Auten, RL. Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2008;295:L38-L43. (2008) Abstract

Auten, RL; Mason, SN; Whorton, MH; Lampe, WR; Foster, WM; Goldberg, RN; Li, B; Stamler, JS; Auten, KM. Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats. American Journal of Respiratory and Critical Care Medicine. 2007;176:291-299. (2007) Abstract

Auten, RL; O'Reilly, MA; Oury, TD; Nozik-Grayck, E; Whorton, MH. Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2006;290:L32-L40. (2006) Abstract

Kinsella, JP; Cutter, GR; Walsh, WF; Gerstmann, DR; Bose, CL; Hart, C; Sekar, KC; Auten, RL; Bhutani, VK; Gerdes, JS; George, TN; Southgate, WM; Carriedo, H; Couser, RJ; Mammel, MC; Hall, DC; Pappagallo, M; Sardesai, S; Strain, JD; Baier, M; Abman, SH. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. New England Journal of Medicine. 2006;355:354-364. (2006) Abstract

Vozzelli, MA; Mason, SN; Whorton, MH; Auten, RL. Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2004;286:L488-L493. (2004) Abstract

Yi, M; Jankov, RP; Belcastro, R; Humes, D; Copland, I; Shek, S; Sweezey, NB; Post, M; Albertine, KH; Auten, RL; Tanswell, AK. Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat. American Journal of Respiratory and Critical Care Medicine. 2004;170:1188-1196. (2004) Abstract

Ahmed, MN; Suliman, HB; Folz, RJ; Nozik-Grayck, E; Golson, ML; Mason, SN; Auten, RL. Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. American Journal of Respiratory and Critical Care Medicine. 2003;167:400-405. (2003) Abstract

Auten, RL; Whorton, MH; Nicholas Mason, S. Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. American Journal of Respiratory Cell and Molecular Biology. 2002;26:391-397. (2002) Abstract

Auten, RL; Mason, SN; Tanaka, DT; Welty-Wolf, K; Whorton, MH. Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2001;281:L336-L344. (2001) Abstract

Auten, RL; Richardson, RM; White, JR; Mason, SN; Vozzelli, MA; Whorton, MH. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. Journal of Pharmacology and Experimental Therapeutics. 2001;299:90-95. (2001) Abstract

Offenbacher, S; Lieff, S; Boggess, KA; Murtha, AP; Madianos, PN; Champagne, CM; McKaig, RG; Jared, HL; Mauriello, SM; Auten, RL; Herbert, WN; Beck, JD. Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction. Annals of periodontology / the American Academy of Periodontology. 2001;6:164-174. (2001) Abstract

Auten, RL; Merzbach, J; Myers, G; Goldstein, RF; Palumbo, D. Neurodevelopmental and health outcomes in term infants treated with surfactant for severe respiratory failure. Journal of Perinatology. 2000;20:291-294. (2000) Abstract

Deng, H; Mason, SN; Auten, RL. Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. American Journal of Respiratory and Critical Care Medicine. 2000;162:2316-2323. (2000) Abstract

Allred, TF; Mercer, RR; Thomas, RF; Deng, H; Auten, RL. Brief 95% O2 exposure effects on surfactant protein and mRNA in rat alveolar and bronchiolar epithelium. American Journal of Physiology. 1999;276:L999-L1009. (1999) Abstract

Hudak, ML; Martin, DJ; Egan, EA; Matteson, EJ; Cummings, NJ; Jung, AL; Kimberlin, LV; Auten, RL; Rosenberg, AA; Asselin, JM; Belcastro, MR; Donohue, PK; Hamm, CR; Jansen, RD; Brody, AS; Riddlesberger, MM; Montgomery, P. A multicenter randomized masked comparison trial of synthetic surfactant versus calf lung surfactant extract in the prevention of neonatal respiratory distress syndrome. Pediatrics. 1997;100:39-50. (1997) Abstract

Hudak, ML; Farrell, EE; Rosenberg, AA; Jung, AL; Auten, RL; Durand, DJ; Horgan, MJ; Buckwald, S; Belcastro, MR; Donohue, PK; Carrion, V; Maniscalco, WW; Balsan, MJ; Torres, BA; Miller, RR; Jansen, RD; Graeber, JE; Laskay, KM; Matteson, EJ; Egan, EA; Brody, AS; Martin, DJ; Riddlesberger, MM; Montgomery, P. A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome. Journal of Pediatrics. 1996;128:396-406. (1996) Abstract

Clyde, BL; Chang, LY; Auten, RL; Ho, YS; Crapo, JD. Distribution of manganese superoxide dismutase mRNA in normal and hyperoxic rat lung. American Journal of Respiratory Cell and Molecular Biology. 1993;8:530-537. (1993) Abstract

Auten, RL; Notter, RH; Kendig, JW; Davis, JM; Shapiro, DL. Surfactant treatment of full-term newborns with respiratory failure. Pediatrics. 1991;87:101-107. (1991) Abstract

Horowitz, S; Watkins, RH; Auten, RL; Mercier, CE; Cheng, ER. Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types of hyperoxic lung. American Journal of Respiratory Cell and Molecular Biology. 1991;5:511-515. (1991) Abstract

Auten, RL; Watkins, RH; Shapiro, DL; Horowitz, S. Surfactant apoprotein A (SP-A) is synthesized in airway cells. American Journal of Respiratory Cell and Molecular Biology. 1990;3:491-496. (1990) Abstract