Department / Division
Psychiatry / Brain Stimulation and Neurophysiology
Durham, NC 27710
Affective disorders, electroconvulsive therapy, schizophrenia, electroencephalography
Research efforts under my direction are in electroconvulsive therapy (ECT). First, in a study of unilateral versus bilateral ECT in elderly unilateral ECT non-responders, we have shown that switching to bilateral ECT is associated with a more substantial and enduring response. We have also shown that switching to bilateral ECT is, however, associated with an increase in memory impairment compared to continuing unilateral ECT. Other ongoing ECT work focuses on the effects of various types of stimulus dosing paradigms on therapeutic response, memory impairment, and EEG abnormality. This work already suggests that moderate intensity dosing improves therapeutic response, but, again, at the cost of more substantial memory effects. With respect to this latter study, as well as other pilot work, we have also demonstrated an ability to separate EEG seizures produced by various kinds of ECT treatment parameters. We are continuing this work in order to more fully develop electroencephalographic models of treatment adequate with ECT.
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