Department / Division:
Pediatrics / Hematology-Oncology

Address:
DUMC 102382
Durham, NC 27710

Appointment Telephone:
919-668-4000

Office Telephone:
919-684-3401

Fax Telephone:
919-681-7950

• MD, Emory University School of Medicine (Georgia), 1993

• Pediatrics, Emory University (Georgia), 1993-1996

• Pediatric Hematology, Oncology and Bone Marrow Transplantation, St. Jude Children's Research Hospital (Tennessee), 2000-2004

• PhD, Philosophy, Emory University (Georgia), 2001

Clinical Interests:
Research focused on improving therapeutics for neuroblastoma, improving the quality of life of children with complex, chronic or fatal illnesses, and study of areas where medical and theological interests intersect

Research Interests:
In the past several years I have focused much of my effort on hematopoietic stem cell transplantation, and on bringing a novel monoclonal antibody from pre-clinical studies, through protein production, to trial for children with GD2-expressing tumors such as neuroblastoma.  More recently I have turned my energy toward improving the quality of life for children and their families throughout the trajectory of their illness.  This work includes development of education programs, research in decision-making at the end of life (most recently involving a grant-funded project in improving ways for children to participate in end-of-life decision making) and programatic development aimed at building support for clinicians caring for children with complex, chronic or life-limiting disease.  My work has also turned towards the valuable lessons that can be learned about the meaning of illness and well-being at the intersection of medicine, theology, philosophy and literature.  In this area I am developing courses at this intersection, as well as putting together a program called 'The Healing Arts: Divinity, Medicine, Nursing' that brings together students from the schools of medicine, nursing and divinity around issues of illness, suffering and death.

Representative Publications:
Read K, Fernandez CV, Gao J, Strahlendorf C, Moghrabi A, Pentz RD, Barfield RC, Baker JN, Santor D, Weijer C, Kodish E. Decision-making by Adolescents and Parents of Children With Cancer Regarding Health Research Participation. Pediatrics. 2009 Aug 10. (2009) Abstract

Navid F, Armstrong M, Barfield RC. Immune therapies for neuroblastoma. Cancer Biol Ther. 2009 May;8(10):874-82. (2009) Abstract

Fernandez CV, Gao J, Strahlendorf C, Moghrabi A, Pentz RD, Barfield RC, Baker JN, Santor D, Weijer C, Kodish E. Providing research results to participants: attitudes and needs of adolescents and parents of children with cancer. J Clin Oncol. 2009 Feb 20;27(6):878-83. (2009) Abstract

Chen X, Knowles J, Barfield RC, Kasow KA, Madden R, Woodard P, Srivastava DK, Horwitz EM, Handgretinger R, Hale GA. A novel approach for quantification of KIR expression in healthy donors and pediatric recipients of hematopoietic SCTs. Bone Marrow Transplant. 2009 Apr;43(7):525-32. (2009) Abstract

Call SK, Kasow KA, Barfield R, Madden R, Leung W, Horwitz E, Woodard P, Panetta JC, Baker S, Handgretinger R, Rodman J, Hale GA. Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantation. Biol Blood Marrow Transplant. 2009 Feb;15(2):274-8. (2009) Abstract

Tamburro RF, Barfield RC, Shaffer ML, Rajasekaran S, Woodard P, Morrison RR, Howard SC, Fiser RT, Schmidt JE, Sillos EM. Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation. Pediatr Crit Care Med. 2008 May;9(3):270-7. (2008) Abstract

Pentz RD, Haight AE, Noll RB, Barfield R, Pelletier W, Davies S, Alderfer MA, Hinds PS. The ethical justification for minor sibling bone marrow donation: a case study. Oncologist. 2008 Feb;13(2):148-51. (2008) Abstract

Barfield RC, Kasow KA, Hale GA. Advances in pediatric hematopoietic stem cell transplantation. Cancer Biol Ther. 2008 Oct;7(10):1533-9. (2008) Abstract

Barfield RC, Kane JR. Balancing disclosure of diagnosis and assent for research in children with HIV. JAMA. 2008 Aug 6;300(5):576-8. (2008) Abstract

Baker JN, Hinds PS, Spunt SL, Barfield RC, Allen C, Powell BC, Anderson LH, Kane JR. Integration of palliative care practices into the ongoing care of children with cancer: individualized care planning and coordination. Pediatr Clin North Am. 2008 Feb;55(1):223-50, xii. (2008) Abstract

Otto M, Chen X, Martin WJ, Leung W, Knowles J, Holladay M, Houston J, Handgretinger R, Barfield RC. Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation. Stem Cells. 2007 Feb;25(2):537-42. (2007) Abstract

Chen X, Hale GA, Neale GA, Knowles J, Barfield RC, Wang YD, Kaushal D, Naeve DC, Srivastava DK, Tong X, Turner V, Naeve CW, Handgretinger R. A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. Exp Hematol. 2007 May;35(5):831-41. (2007) Abstract

Chaleff S, Otto M, Barfield RC, Leimig T, Iyengar R, Martin J, Holiday M, Houston J, Geiger T, Huppert V, Handgretinger R. A large-scale method for the selective depletion of alphabeta T lymphocytes from PBSC for allogeneic transplantation. Cytotherapy. 2007;9(8):746-54. (2007) Abstract

Camp JW, Barfield RC, Rodriguez V, Young AJ, Finerman R, Caniza MA. CHALLENGES FACED BY RESEARCH ETHICS COMMITTEES IN EL SALVADOR: RESULTS FROM A FOCUS GROUP STUDY. Dev World Bioeth. 2007 Dec 18. (2007) Abstract

Barfield RC, Hale GA, Burnette K, Behm FG, Knapp K, Eldridge P, Handgretinger R. Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007 Mar;48(3):349-53. (2007) Abstract

Barfield R. Conscience is the means by which we engage the moral dimension of medicine. Am J Bioeth. 2007 Dec;7(12):26-7; discussion W1-2. (2007) Abstract

Baker JN, Barfield R, Hinds PS, Kane JR. A process to facilitate decision making in pediatric stem cell transplantation: the individualized care planning and coordination model. Biol Blood Marrow Transplant. 2007 Mar;13(3):245-54. (2007) Abstract

Woodard P, Barfield R, Hale G, Horwitz E, Leung W, Ribeiro R, Rubnitz J, Srivistava DK, Tong X, Yusuf U, Raimondi S, Pui CH, Handgretinger R, Cunningham JM. Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndrome. Pediatr Blood Cancer. 2006 Dec;47(7):931-5. (2006) Abstract

Chen X, Hale GA, Barfield R, Benaim E, Leung WH, Knowles J, Horwitz EM, Woodard P, Kasow K, Yusuf U, Behm FG, Hayden RT, Shurtleff SA, Turner V, Srivastava DK, Handgretinger R. Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. Br J Haematol. 2006 Nov;135(4):524-32. (2006) Abstract

Caniza MA, Clara W, Maron G, Navarro-Marin JE, Rivera R, Howard SC, Camp J, Barfield RC. Establishment of ethical oversight of human research in El Salvador: lessons learned. Lancet Oncol. 2006 Dec;7(12):1027-33. (2006) Abstract

Barfield RC, Kodish E. Pediatric ethics in the age of molecular medicine. Pediatr Clin North Am. 2006 Aug;53(4):639-48. (2006) Abstract

Otto M, Barfield RC, Martin WJ, Iyengar R, Leung W, Leimig T, Chaleff S, Gillies SD, Handgretinger R. Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma. Clin Cancer Res. 2005 Dec 1;11(23):8486-91. (2005) Abstract

Otto M, Barfield RC, Iyengar R, Gatewood J, Müller I, Holladay MS, Houston J, Leung W, Handgretinger R. Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation. J Immunother. 2005 Jan-Feb;28(1):73-8. (2005) Abstract

Chen X, Barfield R, Benaim E, Leung W, Knowles J, Lawrence D, Otto M, Shurtleff SA, Neale GA, Behm FG, Turner V, Handgretinger R. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood. 2005 Jan 15;105(2):886-93. (2005) Abstract

Barfield RC, Church C. Informed consent in pediatric clinical trials. Curr Opin Pediatr. 2005 Feb;17(1):20-4. (2005) Abstract

Barfield RC, Otto M, Houston J, Holladay M, Geiger T, Martin J, Leimig T, Gordon P, Chen X, Handgretinger R. A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. Cytotherapy. 2004;6(1):1-6. (2004) Abstract