Physicians

Departments / Divisions

• Pediatrics / Pediatrics-Hematology/Oncology
• School of Nursing

Address
DUMC 102382
Durham, NC 27710

Appointment Telephone
919-684-3401

Office Telephone
919-684-3401

Fax Telephone
919-681-7950

Training

• MD, Emory University School of Medicine (Georgia), 1993

Residency

• Pediatrics, Emory University Hospital (Georgia), 1993-1996

Fellowship

• Pediatric Hematology, Oncology and Bone Marrow Transplantation, Saint Jude Children's Research Hospital (Tennessee), 2000-2004

Other Training

• PhD, Philosophy, Emory University (Georgia), 2001

Clinical Interests
Research focused on improving therapeutics for neuroblastoma, improving the quality of life of children with complex, chronic or fatal illnesses, and study of areas where medical and theological interests intersect

Research Interests

Ray Barfield joined the faculties of Duke's Medical School and Divinity School in 2008. He is married to Karen Barfield, who is an Episcopal priest. Ray and Karen have two children, Micah and Alexandra.

Dr. Barfield came from St. Jude Children's Research Hospital, where his research and practice focused on improving immune therapies for childhood cancer (including bone marrow transplantation and antibody therapy), and understanding the moral aspects of decision-making in medical research involving children. At Duke he has turned much of his effort towards bridging activities in theology and medicine. On the medical side of campus he continues to practice as a pediatric oncologist, and he directs the Pediatric Quality of Life/Palliative Care Program, a program that combines medical care, education and research to benefit children with complex, chronic or potentially life-limiting disease. In the Divinity School he develops courses that address topics at the intersection of theology, medicine and culture. He also teaches courses in Christian philosophy.  He is the director of a new initiative called Theology, Medicine, and Culture.

While he continues to publish research papers in oncology and palliative care, much of his current writing focuses on the impact of literature on philosophical thought, and the ways that literature and narrative open up philosophically engaging dimensions of human experience, not least the experiences of illness and suffering. He has over eighty publications in medicine, philosophy and poetry. His book The Ancient Quarrel Between Poetry and Philosophy was recently published by Cambridge University Press, and he has a forthcoming book-length collection of poetry called Life in the Blind Spot.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Barfield, RC; Brandon, D; Thompson, J; Harris, N; Schmidt, M; Docherty, S. Mind the child: using interactive technology to improve child involvement in decision making about life-limiting illness. The American Journal of Bioethics. 2010;10:28-30. (2010) Abstract

Delgado, E; Barfield, RC; Baker, JN; Hinds, PS; Yang, J; Nambayan, A; Quintana, Y; Kane, JR. Availability of palliative care services for children with cancer in economically diverse regions of the world. European Journal of Cancer. 2010;46:2260-2266. (2010) Abstract

Navid, F; Santana, VM; Barfield, RC. Anti-GD2 antibody therapy for GD2-expressing tumors. Current Cancer Drug Targets. 2010;10:200-209. (2010) Abstract

Rajasekaran, S; Jones, DP; Avent, Y; Shaffer, ML; Elbahlawan, L; Henderson, N; Barfield, RC; Morrison, RR; Tamburro, RF. Outcomes of hematopoietic stem cell transplant patients who received continuous renal replacement therapy in a pediatric oncology intensive care unit. Pediatric Critical Care Medicine. 2010;11:699-706. (2010) Abstract

Sorkin, LS; Otto, M; Baldwin, WM; Vail, E; Gillies, SD; Handgretinger, R; Barfield, RC; Ming Yu, H; Yu, AL. Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain. 2010;149:135-142. (2010) Abstract

Young, AJ; Kim, L; Shu Li, ; Baker, JN; Schmidt, M; Camp, JW; Barfield, RC. Agency and communication challenges in discussions of informed consent in pediatric cancer research. Qualitative Health Research. 2010;20:628-643. (2010) Abstract

Call, SK; Kasow, KA; Barfield, R; Madden, R; Leung, W; Horwitz, E; Woodard, P; Panetta, JC; Baker, S; Handgretinger, R; Rodman, J; Hale, GA. Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantation. Biology of Blood and Marrow Transplantation. 2009;15:274-278. (2009) Abstract

Camp, JW; Barfield, RC; Rodriguez, V; Young, AJ; Finerman, R; Caniza, MA. Challenges faced by research ethics committees in El Salvador: results from a focus group study. Developing World Bioethics. 2009;9:11-17. (2009) Abstract

Chen, X; Knowles, J; Barfield, RC; Kasow, KA; Madden, R; Woodard, P; Srivastava, DK; Horwitz, EM; Handgretinger, R; Hale, GA. A novel approach for quantification of KIR expression in healthy donors and pediatric recipients of hematopoietic SCTs. Bone Marrow Transplantation. 2009;43:525-532. (2009) Abstract

Fernandez, CV; Gao, J; Strahlendorf, C; Moghrabi, A; Pentz, RD; Barfield, RC; Baker, JN; Santor, D; Weijer, C; Kodish, E. Providing research results to participants: attitudes and needs of adolescents and parents of children with cancer. Journal of Clinical Oncology. 2009;27:878-883. (2009) Abstract

Navid, F; Armstrong, M; Barfield, RC. Immune therapies for neuroblastoma. Cancer Biology and Therapy. 2009;8:874-882. (2009) Abstract

Read, K; Fernandez, CV; Gao, J; Strahlendorf, C; Moghrabi, A; Pentz, RD; Barfield, RC; Baker, JN; Santor, D; Weijer, C; Kodish, E. Decision-making by adolescents and parents of children with cancer regarding health research participation. Pediatrics. 2009;124:959-965. (2009) Abstract

Baker, JN; Hinds, PS; Spunt, SL; Barfield, RC; Allen, C; Powell, BC; Anderson, LH; Kane, JR. Integration of palliative care practices into the ongoing care of children with cancer: individualized care planning and coordination. Pediatric Clinics of North America. 2008;55:223-xii. (2008) Abstract

Barfield, RC; Kane, JR. Balancing disclosure of diagnosis and assent for research in children with HIV. JAMA: Journal of the American Medical Association. 2008;300:576-578. (2008) Abstract

Barfield, RC; Kasow, KA; Hale, GA. Advances in pediatric hematopoietic stem cell transplantation. Cancer Biology and Therapy. 2008;7:1533-1539. (2008) Abstract

Pentz, RD; Haight, AE; Noll, RB; Barfield, R; Pelletier, W; Davies, S; Alderfer, MA; Hinds, PS. The ethical justification for minor sibling bone marrow donation: a case study. The Oncologist. 2008;13:148-151. (2008) Abstract

Tamburro, RF; Barfield, RC; Shaffer, ML; Rajasekaran, S; Woodard, P; Morrison, RR; Howard, SC; Fiser, RT; Schmidt, JE; Sillos, EM. Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation. Pediatric Critical Care Medicine. 2008;9:270-277. (2008) Abstract

Baker, JN; Barfield, R; Hinds, PS; Kane, JR. A process to facilitate decision making in pediatric stem cell transplantation: the individualized care planning and coordination model. Biology of Blood and Marrow Transplantation. 2007;13:245-254. (2007) Abstract

Barfield, R. Conscience is the means by which we engage the moral dimension of medicine. The American Journal of Bioethics. 2007;7:26-27. (2007) Abstract

Barfield, RC; Hale, GA; Burnette, K; Behm, FG; Knapp, K; Eldridge, P; Handgretinger, R. Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia. Pediatric Blood and Cancer. 2007;48:349-353. (2007) Abstract

Chaleff, S; Otto, M; Barfield, RC; Leimig, T; Iyengar, R; Martin, J; Holiday, M; Houston, J; Geiger, T; Huppert, V; Handgretinger, R. A large-scale method for the selective depletion of alphabeta T lymphocytes from PBSC for allogeneic transplantation. Cytotherapy. 2007;9:746-754. (2007) Abstract

Chen, X; Hale, GA; Neale, GA; Knowles, J; Barfield, RC; Wang, YD; Kaushal, D; Naeve, DC; Srivastava, DK; Tong, X; Turner, V; Naeve, CW; Handgretinger, R. A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. Experimental Hematology. 2007;35:831-841. (2007) Abstract

Otto, M; Chen, X; Martin, WJ; Leung, W; Knowles, J; Holladay, M; Houston, J; Handgretinger, R; Barfield, RC. Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation. Stem Cells. 2007;25:537-542. (2007) Abstract

Barfield, RC; Kodish, E. Pediatric ethics in the age of molecular medicine. Pediatric Clinics of North America. 2006;53:639-648. (2006) Abstract

Caniza, MA; Clara, W; Maron, G; Navarro-Marin, JE; Rivera, R; Howard, SC; Camp, J; Barfield, RC. Establishment of ethical oversight of human research in El Salvador: lessons learned. Lancet Oncology. 2006;7:1027-1033. (2006) Abstract

Chen, X; Hale, GA; Barfield, R; Benaim, E; Leung, WH; Knowles, J; Horwitz, EM; Woodard, P; Kasow, K; Yusuf, U; Behm, FG; Hayden, RT; Shurtleff, SA; Turner, V; Srivastava, DK; Handgretinger, R. Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. British Journal of Haematology. 2006;135:524-532. (2006) Abstract

Woodard, P; Barfield, R; Hale, G; Horwitz, E; Leung, W; Ribeiro, R; Rubnitz, J; Srivistava, DK; Tong, X; Yusuf, U; Raimondi, S; Pui, CH; Handgretinger, R; Cunningham, JM. Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndrome. Pediatric Blood and Cancer. 2006;47:931-935. (2006) Abstract

Barfield, RC; Church, C. Informed consent in pediatric clinical trials. Current Opinion in Pediatrics. 2005;17:20-24. (2005) Abstract

Chen, X; Barfield, R; Benaim, E; Leung, W; Knowles, J; Lawrence, D; Otto, M; Shurtleff, SA; Neale, GA; Behm, FG; Turner, V; Handgretinger, R. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood. 2005;105:886-893. (2005) Abstract

Otto, M; Barfield, RC; Iyengar, R; Gatewood, J; Müller, I; Holladay, MS; Houston, J; Leung, W; Handgretinger, R. Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation. Journal of Immunotherapy. 2005;28:73-78. (2005) Abstract

Otto, M; Barfield, RC; Martin, WJ; Iyengar, R; Leung, W; Leimig, T; Chaleff, S; Gillies, SD; Handgretinger, R. Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma. Clinical Cancer Research. 2005;11:8486-8491. (2005) Abstract

Barfield, RC; Otto, M; Houston, J; Holladay, M; Geiger, T; Martin, J; Leimig, T; Gordon, P; Chen, X; Handgretinger, R. A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. Cytotherapy. 2004;6:1-6. (2004) Abstract