Physicians

Department / Division
Ophthalmology / Glaucoma Ophthalmology

Address
DUMC 3802
Durham, NC 27710

Appointment Telephone
919-681-3937

Office Telephone
919-681-2793

Fax Telephone
919-681-8267

Training

• MD, University of Florida College of Medicine, 1993

Residency

• Internal Medicine, Emory University Hospital (Georgia), 1993-1995
• Ophthalmology, University of Florida College of Medicine, 1995-1998

Fellowship

• Glaucoma, Duke University Medical Center, 1998-2000

Clinical Interests
Diagnosis and treatment of glaucoma, including medical, laser, and surgical therapies; cataract evaluation and treatment; glaucoma implant surgery; combined glaucoma and cataract surgery; research interests include genetic studies of inherited eye diseases and novel drug-delivery techniques

Research Interests
As a physician-scientist investigator, Dr. Challa has a special research interest in the genetic basis of inherited eye diseases. He has active projects investigating the genetics of Pseudoexfoliation associated glaucoma and the cellular basis for glaucoma development. He also studies ocular drug delivery and is involved in developing long-term delivery devices for glaucoma medications. He also investigates novel compounds that may eventually be used for treating glaucoma. In addition to basic science research, he also has clinical research interests including evaluating the effectiveness of new glaucoma therapies.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Aerie Pharmaceuticals, Inc.

Representative Publications
Li, G; Luna, C; Navarro, ID; Epstein, DL; Huang, W; Gonzalez, P; Challa, P. Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. Investigative Ophthalmology and Visual Science. 2011;52:4395-4401. (2011) Abstract

Khan, TT; Li, G; Navarro, ID; Kastury, RD; Zeil, CJ; Semchyshyn, TM; Moya, FJ; Epstein, DL; Gonzalez, P; Challa, P. LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma. Molecular Vision. 2010;16:2236-2241. (2010) Abstract

Patel, M; Challa, P; Afshari, NA. Descemet's stripping automated endothelial keratoplasty in a patient with four glaucoma tubes. Annals of Ophthalmology. 2010;42 Spec No:20-23. (2010) Abstract

Arnold, JJ; Choksi, Y; Chen, X; Shimazaki, A; Hatten, J; Toone, EJ; Epstein, DL; Challa, P. Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. Journal of Ocular Pharmacology and Therapeutics. 2009;25:179-186. (2009) Abstract

Challa, P. Genetics of pseudoexfoliation syndrome. Current Opinion in Ophthalmology. 2009;20:88-91. (2009) Abstract

Luna, C; Li, G; Liton, PB; Qiu, J; Epstein, DL; Challa, P; Gonzalez, P. Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. Food and Chemical Toxicology. 2009;47:198-204. (2009) Abstract

Luna, C; Li, G; Qiu, J; Challa, P; Epstein, DL; Gonzalez, P. Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. Investigative Ophthalmology and Visual Science. 2009;50:5805-5810. (2009) Abstract

Muir, KW; Santiago-Turla, C; Stinnett, SS; Herndon, LW; Allingham, RR; Challa, P; Lee, PP. Glaucoma patients' trust in the physician. Journal of Ophthalmology. 2009;2009:476726. (2009) Abstract

Stein, JD; McCoy, AN; Asrani, S; Herndon, LW; Lee, PP; McKinnon, SJ; Allingham, RR; Challa, P. Surgical management of hypotony owing to overfiltration in eyes receiving glaucoma drainage devices. Journal of Glaucoma. 2009;18:638-641. (2009) Abstract

Challa, P. Glaucoma genetics. International Ophthalmology Clinics. 2008;48:73-94. (2008) Abstract

Challa, P; Schmidt, S; Liu, Y; Qin, X; Vann, RR; Gonzalez, P; Allingham, RR; Hauser, MA. Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma. Molecular Vision. 2008;14:146-149. (2008) Abstract

Jagadeesan, R; Kalyan, DN; Lee, P; Stinnett, S; Challa, P. Use of a standardized patient satisfaction questionnaire to assess the quality of care provided by ophthalmology residents. Ophthalmology. 2008;115:738-743.e3. (2008) Abstract

Liu, X; Zhang, M; Liu, Y; Challa, P; Gonzalez, P; Liu, Y. Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits. Molecular Vision. 2008;14:2404-2412. (2008) Abstract

Liu, Y; Akafo, S; Santiago-Turla, C; Cohen, CS; Larocque-Abramson, KR; Qin, X; Herndon, LW; Challa, P; Schmidt, S; Hauser, MA; Allingham, RR. Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma. Molecular Vision. 2008;14:2367-2372. (2008) Abstract

Liu, Y; Schmidt, S; Qin, X; Gibson, J; Hutchins, K; Santiago-Turla, C; Wiggs, JL; Budenz, DL; Akafo, S; Challa, P; Herndon, LW; Hauser, MA; Allingham, RR. Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations. Investigative Ophthalmology and Visual Science. 2008;49:3465-3468. (2008) Abstract

Muir, KW; Santiago-Turla, C; Stinnett, SS; Herndon, LW; Allingham, RR; Challa, P; Lee, PP. Health literacy and vision-related quality of life. British Journal of Ophthalmology. 2008;92:779-782. (2008) Abstract