Physicians

Division Chief, Cardiovascular and Thoracic Surgery

Department / Division
Surgery / Cardiovascular & Thoracic

Address
DUMC 3442
Durham, NC 27710

Appointment Telephone
919-684-2890

Office Telephone
919-684-2890

Fax Telephone
919-681-7905

Training

• MD, Duke University School of Medicine, 1977

Residency

• Cardiovascular Research, Duke University Medical Center, 1987
• Teaching Scholar, AHA Clinician Scientist Awardee, Duke University Medical Center, 1980-1983

Clinical Interests
Adult cardiac surgery with emphasis on coronary artery disease and valvular heart surgery

Research Interests
Dr. Smith is the Prinicpal Investigator for the Duke site in the Cardiothoracic Surgery Clinical Trials Network (CTSN) and in recent years has focused his research efforts in clinical research. The CTSN is an NHLBI sponsored network developed to promote clinical research in cardiac surgery, and is now entering its 7th year of funding with a commitment now for an additional 5 years. Dr. Smith is the national PI for a randomized clinical trial comparing CABG alone to CABG with mitral repair for moderate ischemic mitral regurgitation. This trial is nearing completion of enrollment, and he is now the PI of a clinical trial of FFR vs angiographically guided CABG expected to begin national enrollment in September of 2013. Duke has participated as a site in 3 additional CTSN trials, and is one of two sites awarded NHLBI funding as a Clinical Skills Education Core. This funding is designed to formally develop surgical clinical trialists and promote clinical research capacity within our specialty. The Duke site has thus far sponsored 6 CTSN scholars who have all received Masters degrees in clinical research, participated in CTSN protocols and other activities of the Network. Additionally, Dr. Smith has been awarded site funding from the Veteran’s Administration to begin VA cooperative clinical research trials at the Durham VA. Through all of these activities, an integration of clinical research, publications, and scholarship with the advancement of clinically effective Thoracic Surgery is the goal.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• CSL Behring AG

Representative Publications
Albahrani, MJ; Swaminathan, M; Phillips-Bute, B; Smith, PK; Newman, MF; Mathew, JP; Stafford-Smith, M. Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation. Anesthesia and Analgesia. 2003;96:637-643. (2003) Abstract

Amory, DW; Grigore, A; Amory, JK; Gerhardt, MA; White, WD; Smith, PK; Schwinn, DA; Reves, JG; Newman, MF. Neuroprotection is associated with beta-adrenergic receptor antagonists during cardiac surgery: evidence from 2,575 patients. Journal of Cardiothoracic and Vascular Anesthesia. 2002;16:270-277. (2002) Abstract

Grocott, HP; Mackensen, GB; Grigore, AM; Mathew, J; Reves, JG; Phillips-Bute, B; Smith, PK; Newman, MF; Neurologic Outcome Research Group (NORG), ; Cardiothoracic Anesthesiology Research Endeavors (CARE) Investigators' of the Duke Heart Center. Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery. Stroke. 2002;33:537-541. (2002) Abstract

Milano, CA; Patel, VS; Smith, PK; Smith, MS. Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation. Journal of Heart and Lung Transplantation. 2002;21:1127-1130. (2002) Abstract

O'Connor, CM; Velazquez, EJ; Gardner, LH; Smith, PK; Newman, MF; Landolfo, KP; Lee, KL; Califf, RM; Jones, RH. Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank). American Journal of Cardiology. 2002;90:101-107. (2002) Abstract

Scarborough, JE; Smith, ML; Domkowski, PW; Diodato, LH; Pippen, AM; Smith, PK; Annex, BH; Landolfo, KP. Basic fibroblast growth factor is upregulated in hibernating myocardium. Journal of Surgical Research. 2002;107:119-123. (2002) Abstract

Sharma, AD; Slaughter, TF; Clements, FM; Sreeram, G; Newman, MF; Phillips-Bute, B; Bredehoeft, SJ; Smith, PK; Stafford-Smith, M. Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgery. Surgical Infections. 2002;3:127-133. (2002) Abstract

Smith, PK; Cowie, H; Olafsson, RF; Liefooghe, AP; Almeida, A; Araki, H; del Barrio, C; Costabile, A; Dekleva, B; Houndoumadi, A; Kim, K; Olafsson, RP; Ortega, R; Pain, J; Pateraki, L; Schafer, M; Singer, M; Smorti, A; Toda, Y; Tomasson, H; Wenxin, Z. Definitions of bullying: a comparison of terms used, and age and gender differences, in a fourteen-country international comparison. Child Development. 2002;73:1119-1133. (2002) Abstract

Swaminathan, M; McCreath, BJ; Phillips-Bute, BG; Newman, MF; Mathew, JP; Smith, PK; Blumenthal, JA; Stafford-Smith, M; Perioperative Outcomes Research Group. Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction. Anesthesia and Analgesia. 2002;95:1-8. (2002) Abstract

Welsby, IJ; Bennett-Guerrero, E; Atwell, D; White, WD; Newman, MF; Smith, PK; Mythen, MG. The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass. Anesthesia and Analgesia. 2002;94:1072-1078. (2002) Abstract

Grigore, AM; Mathew, J; Grocott, HP; Reves, JG; Blumenthal, JA; White, WD; Smith, PK; Jones, RH; Kirchner, JL; Mark, DB; Newman, MF; Neurological Outcome Research Group, ; CARE Investigators of the Duke Heart Center. Cardiothoracic Anesthesia Research Endeavors. Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery. Anesthesiology. 2001;95:1110-1119. (2001) Abstract

Sapirstein, JS; Smith, PK. The "ideal" replacement heart valve. American Heart Journal. 2001;141:856-860. (2001) Abstract

Saur, CD; Granger, BB; Muhlbaier, LH; Forman, LM; McKenzie, RJ; Taylor, MC; Smith, PK. Depressive symptoms and outcome of coronary artery bypass grafting. American Journal of Critical Care. 2001;10:4-10. (2001) Abstract

Swaminathan, M; East, C; Phillips-Bute, B; Newman, MF; Reves, JG; Smith, PK; Stafford-Smith, M. Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance. Annals of Thoracic Surgery. 2001;72:1603-1609. (2001) Abstract