Department / Division:
Pediatrics / Pulmonary and Sleep Medicine

Address:
DUMC 102360
Durham, NC 27710

Appointment Telephone:
919-668-4000 or 919-681-3364

Office Telephone:
919-681-3364

Fax Telephone:
919-684-2292

• MD, Jefferson Medical College of Thomas Jefferson University (Pennsylvania), 1983

• Pediatrics, St. Christopher's Hospital for Children (Pennsylvania), 1986

• Pediatric Pulmonology, UNC Hospitals, 1995

• MS, Clinical Research, University of Pittsburgh (Pennsylvania), 2007

Clinical Interests:
All pediatric lung diseases, cystic fibrosis, asthma, obesity, exercise and airway anomalies

Research Interests:
Outcomes investigation has been the focus of my research activity over the last few years, specifically addressing the two main pediatric respiratory diseases, cystic fibrosis and asthma.  While directing the CF clinical research program at the Duke Combined CF Center, we have become part of the CF Foundation's Therapeutic Development Network and become involved in many different clinical trials over the last 12 months.  These include investigation of potential genetic relationships on CF disease progression and outcome, as well as studies of new therapeutics, participating in phase III trials of new agents that might help to slow disease progression.
Regarding asthma, there is still much to be understood regarding reducing asthma morbidity.  Every year, more than half of the estimated 22 million Americans diagnosed with asthma suffer from at least one acute attack.  Focusing his investigations in the area of outcomes research, Dr. Michelson has been looking at risk factors in asthma, including the increasing prevalence of pediatric obesity.  By examining large national databases, he is examining for a potential relationship between obesity and asthma severity in the pediatric population.  Potential new areas of investigation include collaborating with investigators skilled in using Geographic Information System mapping, using these tools to study obesity as well as the impact of the ‘built environment’ on asthma incidence.

Representative Publications:
1. Michelson P, Watkins B, Webber SA, Wadowsky R, Michaels MG, 2008.  Screening for PTLD in lung and heart–lung transplant recipients by measuring EBV DNA load in bronchoalveolar lavage fluid using real time PCR.  Pediatr Transplant. Jun; 12(4):  464-468.
2. Kremer TM, Zwerdling RG, Michelson PH, O’Sullivan BP, 2008.  Intensive Care Manage-ment of the patient with Cystic Fibrosis. J Intensive Care Med. May-Jun; 23(3):159-77.
3. Kurland G, Goyal, R and Michelson P, 2007.  Pulmonary Complications of Hematopoetic Cell Transplantation.  Paediatric Respiratory Reviews, Mar; 8 (1):46-61
4. A. Faro, G. B. Mallory, G. A. Visner, O. Elidemir, P. J. Mogayzel Jr, L. Danziger-Isakov, M. Michaels, S. Sweet, P. Michelson, S. Paranjape, C. Conrad, D. A. Waltz. American Society of Transplantation Executive Summary on Pediatric Lung Transplantation. American Journal of Transplantation 2007;7(2):285-92.
5. Steven J. Ambrusko, Sriya Gunawardena Allison Sakara Beth Windsor Lizabeth Lanford Peter Michelson Lakshmanan Krishnamurti. Elevation of tricuspid regurgitant jet velocity, a marker for pulmonary hypertension in children with sickle cell disease. Pediatric Blood & Cancer 2006;47(7):907-13.
6. Kurland, G and Michelson, P. Bronchiolitis obliterans in children. Pediatric Pulmonology 2005;39(3):193-208.
7. Michelson PH, Tigue M, Jones JCR. Human Bronchial Epithelial Cells Secrete Laminin 5, Express Hemidesmosomal Proteins, and Assemble Hemidesmosomes. J. Histochem. Cytochem. 2000;48(4):535-44.
8. Michelson PH DL, Devlin RB, Peden DB. Ozone effects on the immediate-phase response to allergen in the nasal airways of allergic asthmatic subjects. Otolaryngol Head Neck Surg 1999;120(2):225-32.
9. Michelson PH, Tigue M, Panos RJ, Sporn PHS. Keratinocyte growth factor stimulates bronchial epithelial cell proliferation in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol 1999;277(4):L737-42.
10. Michelson PHM, Susanna A. Wheezing or Stridor: Intrinsic and Extrinsic Lesions Causing Noisy Breathing Allergy and Asthma Proceedings 1998;19(2):81-4.