Physicians

Division Chief, Pediatric Blood and Marrow Transplantation

Department / Division
Pediatrics / Pediatric-Blood & Marrow Transplantation

Address
DUMC 3350
Durham, NC 27710

Appointment Telephone
919-668-1100

Office Telephone
919-668-1124

Fax Telephone
919-668-1180

Training

• MD, PhD, Washington University in Saint Louis School of Medicine (Missouri), 1987

Residency

• Pediatrics, Yale-New Haven Hospital (Connecticut), 1987-1989

Fellowship

• Pediatric Hematology-Oncology, Yale-New Haven Hospital (Connecticut), 1989-1992

Clinical Interests
Pediatric oncology, pediatric leukemia, stem-cell transplantation, infections in immunocompromised patients

Research Interests
For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Parikh, SH; Mendizabal, A; Martin, PL; Prasad, VK; Szabolcs, P; Driscoll, TA; Kurtzberg, J. Unrelated donor umbilical cord blood transplantation in pediatric myelodysplastic syndrome: a single-center experience. Biology of Blood and Marrow Transplantation. 2009;15:948-955. (2009) Abstract

Borowitz, MJ; Devidas, M; Hunger, SP; Bowman, WP; Carroll, AJ; Carroll, WL; Linda, S; Martin, PL; Pullen, DJ; Viswanatha, D; Willman, CL; Winick, N; Camitta, BM; Children's Oncology Group. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study. Blood. 2008;111:5477-5485. (2008) Abstract

Davies, SM; Borowitz, MJ; Rosner, GL; Ritz, K; Devidas, M; Winick, N; Martin, PL; Bowman, P; Elliott, J; Willman, C; Das, S; Cook, EH; Relling, MV. Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2008;111:2984-2990. (2008) Abstract

Page, KM; Mendizabal, AM; Prasad, VK; Martin, PL; Parikh, S; Wood, S; Sempowski, GD; Szabolcs, P; Kurtzberg, J. Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation. Biology of Blood and Marrow Transplantation. 2008;14:1108-1117. (2008) Abstract

Prasad, VK; Mendizabal, A; Parikh, SH; Szabolcs, P; Driscoll, TA; Page, K; Lakshminarayanan, S; Allison, J; Wood, S; Semmel, D; Escolar, ML; Martin, PL; Carter, S; Kurtzberg, J. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood. 2008;112:2979-2989. (2008) Abstract

White, MS; Martin, PL; McLean, TW. Acute myelogenous leukemia associated with Ollier disease. Pediatric Blood and Cancer. 2008;50:645-646. (2008) Abstract

Beam, D; Poe, MD; Provenzale, JM; Szabolcs, P; Martin, PL; Prasad, V; Parikh, S; Driscoll, T; Mukundan, S; Kurtzberg, J; Escolar, ML. Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy. Biology of Blood and Marrow Transplantation. 2007;13:665-674. (2007) Abstract

Chauvenet, AR; Martin, PL; Devidas, M; Linda, SB; Bell, BA; Kurtzberg, J; Pullen, J; Pettenati, MJ; Carroll, AJ; Shuster, JJ; Camitta, B. Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201. Blood. 2007;110:1105-1111. (2007) Abstract

Parikh, SH; Szabolcs, P; Prasad, VK; Lakshminarayanan, S; Martin, PL; Driscoll, TA; Kurtzberg, J. Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation. Pediatric Blood and Cancer. 2007;49:982-984. (2007) Abstract

Steinbach, WJ; Addison, RM; McLaughlin, L; Gerrald, Q; Martin, PL; Driscoll, T; Bentsen, C; Perfect, JR; Alexander, BD. Prospective Aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients. Pediatric Infectious Disease Journal. 2007;26:558-564. (2007) Abstract

Martin, PL. To stop or not to stop: how much support should be provided to mechanically ventilated pediatric bone marrow and stem cell transplant patients?. Respiratory Care Clinics of North America. 2006;12:403-419. (2006) Abstract

Martin, PL; Carter, SL; Kernan, NA; Sahdev, I; Wall, D; Pietryga, D; Wagner, JE; Kurtzberg, J. Results of the cord blood transplantation study (COBLT): outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with lysosomal and peroxisomal storage diseases. Biology of Blood and Marrow Transplantation. 2006;12:184-194. (2006) Abstract

Borowitz, MJ; Pullen, DJ; Winick, N; Martin, PL; Bowman, WP; Camitta, B. Comparison of diagnostic and relapse flow cytometry phenotypes in childhood acute lymphoblastic leukemia: implications for residual disease detection: a report from the children's oncology group. Cytometry Part B: Clinical Cytometry. 2005;68:18-24. (2005) Abstract

Hall, JG; Martin, PL; Wood, S; Kurtzberg, J. Unrelated umbilical cord blood transplantation for an infant with beta-thalassemia major. Journal of Pediatric Hematology/Oncology. 2004;26:382-385. (2004) Abstract

Quaranta, BP; Halperin, EC; Kurtzberg, J; Clough, R; Martin, PL. The incidence of testicular recurrence in boys with acute leukemia treated with total body and testicular irradiation and stem cell transplantation. Cancer. 2004;101:845-850. (2004) Abstract

Staba, SL; Escolar, ML; Poe, M; Kim, Y; Martin, PL; Szabolcs, P; Allison-Thacker, J; Wood, S; Wenger, DA; Rubinstein, P; Hopwood, JJ; Krivit, W; Kurtzberg, J. Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. New England Journal of Medicine. 2004;350:1960-1969. (2004) Abstract

Steinbach, WJ; Schell, WA; Miller, JL; Perfect, JR; Martin, PL. Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients. Journal of Infection. 2004;48:112-116. (2004) Abstract

Gururangan, S; McLaughlin, C; Quinn, J; Rich, J; Reardon, D; Halperin, EC; Herndon, J; Fuchs, H; George, T; Provenzale, J; Watral, M; McLendon, RE; Friedman, A; Friedman, HS; Kurtzberg, J; Vredenbergh, J; Martin, PL. High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas. Journal of Clinical Oncology. 2003;21:2187-2191. (2003) Abstract

Hagen, SA; Craig, DM; Martin, PL; Plumer, DD; Gentile, MA; Schulman, SR; Cheifetz, IM. Mechanically ventilated pediatric stem cell transplant recipients: effect of cord blood transplant and organ dysfunction on outcome. Pediatric Critical Care Medicine. 2003;4:206-213. (2003) Abstract

Jaroscak, J; Goltry, K; Smith, A; Waters-Pick, B; Martin, PL; Driscoll, TA; Howrey, R; Chao, N; Douville, J; Burhop, S; Fu, P; Kurtzberg, J. Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System. Blood. 2003;101:5061-5067. (2003) Abstract

Whyte, MP; Kurtzberg, J; McAlister, WH; Mumm, S; Podgornik, MN; Coburn, SP; Ryan, LM; Miller, CR; Gottesman, GS; Smith, AK; Douville, J; Waters-Pick, B; Armstrong, RD; Martin, PL. Marrow cell transplantation for infantile hypophosphatasia. Journal of Bone and Mineral Research. 2003;18:624-636. (2003) Abstract

Benjamin, DK; Miller, WC; Bayliff, S; Martel, L; Alexander, KA; Martin, PL. Infections diagnosed in the first year after pediatric stem cell transplantation. Pediatric Infectious Disease Journal. 2002;21:227-234. (2002) Abstract

Richardson, PG; Murakami, C; Jin, Z; Warren, D; Momtaz, P; Hoppensteadt, D; Elias, AD; Antin, JH; Soiffer, R; Spitzer, T; Avigan, D; Bearman, SI; Martin, PL; Kurtzberg, J; Vredenburgh, J; Chen, AR; Arai, S; Vogelsang, G; McDonald, GB; Guinan, EC. Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome. Blood. 2002;100:4337-4343. (2002) Abstract

Barker, JN; Martin, PL; Coad, JE; DeFor, T; Trigg, ME; Kurtzberg, J; Weisdorf, DJ; Wagner, J. Low incidence of Epstein-Barr virus-associated posttransplantation lymphoproliferative disorders in 272 unrelated-donor umbilical cord blood transplant recipients. Biology of Blood and Marrow Transplantation. 2001;7:395-399. (2001) Abstract

Wainwright, MS; Martin, PL; Morse, RP; Lacaze, M; Provenzale, JM; Coleman, RE; Morgan, MA; Hulette, C; Kurtzberg, J; Bushnell, C; Epstein, L; Lewis, DV. Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Annals of Neurology. 2001;50:612-619. (2001) Abstract

Howrey, RP; Martin, PL; Driscoll, T; Szabolcs, P; Kelly, T; Shpall, EJ; Bearman, SI; Slat-Vasquez, V; Rubinstein, P; Stevens, CE; Kurtzberg, J. Graft-versus-leukemia-induced complete remission following unrelated umbilical cord blood transplantation for acute leukemia. Bone Marrow Transplantation. 2000;26:1251-1254. (2000) Abstract

Klock, B; Pham, T; Smith, LS; Beris, S; Lobo, FM; Martin, PL; Rappeport, J; Fuleihan, RL. When you hear hoof beats...do not forget the zebras. Current Opinion in Pediatrics. 2000;12:172-177. (2000) Abstract

Graham, ML; Asselin, BL; Herndon, JE; Casey, JR; Chaffee, S; Ciocci, GH; Daeschner, CW; Davis, AR; Gold, S; Halperin, EC; Laughlin, MJ; Martin, PL; Olson, JF; Kurtzberg, J. Toxicity, pharmacology and feasibility of administration of PEG-L-asparaginase as consolidation therapy in patients undergoing bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplantation. 1998;21:879-885. (1998) Abstract

Martin, PL; Look, AT; Schnell, S; Harris, MB; Pullen, J; Shuster, JJ; Carroll, AJ; Pettenati, MJ; Rao, PN. Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study. Journal of Pediatric Hematology/Oncology. 1996;18:113-121. (1996) Abstract

Kilpatrick, SE; Teot, LA; Geisinger, KR; Martin, PL; Shumate, DK; Zbieranski, N; Russell, GB; Fletcher, CD. Relationship of DNA ploidy to histology and prognosis in rhabdomyosarcoma. Comparison of flow cytometry and image analysis. Cancer. 1994;74:3227-3233. (1994) Abstract

Martin, PL; Rappeport, JM. Bone marrow transplantation in the perinatal period. Seminars in Perinatology. 1990;14:416-422. (1990) Abstract